Catenarin, an anthraquinone compound, inhibits CXCR4 and CCR5 pathways to protect against type 1 diabetes in NOD mice (72.1)
Yang W, Shen M, Jang Y, Chen Z, Chang C. Catenarin, an anthraquinone compound, inhibits CXCR4 and CCR5 pathways to protect against type 1 diabetes in NOD mice (72.1). The Journal Of Immunology 2012, 188: 72.1-72.1. DOI: 10.4049/jimmunol.188.supp.72.1.Peer-Reviewed Original ResearchType 1 diabetesC-C chemokine receptor type 5Chemokine receptor type 5Expression of CCR5Non-obese diabetic miceCXCR4-mediated chemotaxisCCR5 pathwayNOD micePhosphorylation of mitogen-activated protein kinasesCalcium mobilizationDose-dependentlyMitogen-activated protein kinaseProphylactic agentInflammatory diseasesInhibit CXCR4Cell lossDiabetic miceCCR5Anti-inflammatory compoundsType 5Leukocyte migrationPreventive effectT1DAbstract InflammationCXCR4