2009
Pleiotropy of C-Reactive Protein Gene Polymorphisms With C-Reactive Protein Levels and Heart Rate Variability in Healthy Male Twins
Su S, Lampert R, Zhao J, Bremner JD, Miller A, Snieder H, Lee F, Khan D, Goldberg J, Vaccarino V. Pleiotropy of C-Reactive Protein Gene Polymorphisms With C-Reactive Protein Levels and Heart Rate Variability in Healthy Male Twins. The American Journal Of Cardiology 2009, 104: 1748-1754. PMID: 19962488, PMCID: PMC2818743, DOI: 10.1016/j.amjcard.2009.07.063.Peer-Reviewed Original ResearchConceptsC-reactive protein levelsHeart rate variabilityCRP gene polymorphismsCoronary artery diseaseCRP levelsGene polymorphismsArtery diseaseHRV indicesSymptomatic coronary artery diseaseReduced heart rate variabilityRate variabilityLower heart rate variabilityC-Reactive Protein Gene PolymorphismsPlasma CRP levelsCRP plasma levelsCRP single-nucleotide polymorphismsMale twinsProtein levelsSingle nucleotide polymorphismsHealthy male twinsBivariate structural equation modelingHigh-frequency powerCRP geneFrequency domain measuresProtein gene polymorphisms
2008
Decreased heart rate variability is associated with higher levels of inflammation in middle-aged men
Lampert R, Bremner JD, Su S, Miller A, Lee F, Cheema F, Goldberg J, Vaccarino V. Decreased heart rate variability is associated with higher levels of inflammation in middle-aged men. American Heart Journal 2008, 156: 759.e1-759.e7. PMID: 18926158, PMCID: PMC2587932, DOI: 10.1016/j.ahj.2008.07.009.Peer-Reviewed Original ResearchConceptsC-reactive proteinCoronary artery diseaseBody mass indexHeart rate variabilityTraditional risk factorsInterleukin-6Risk factorsAutonomic functionPhysical activityDevelopment of CADSymptomatic coronary artery diseaseTraditional CAD risk factorsHigh-density lipoprotein cholesterolRate variabilityGraded inverse relationshipCAD risk factorsMiddle-aged menHigh-density lipoproteinAmbulatory electrocardiogram monitoringHigh-frequency powerAutonomic dysfunctionLipoprotein cholesterolArtery diseaseMass indexAutonomic dysregulation
2003
Effects of propranolol on recovery of heart rate variability following acute myocardial infarction and relation to outcome in the Beta-Blocker Heart Attack Trial
Lampert R, Ickovics JR, Viscoli CJ, Horwitz RI, Lee FA. Effects of propranolol on recovery of heart rate variability following acute myocardial infarction and relation to outcome in the Beta-Blocker Heart Attack Trial. The American Journal Of Cardiology 2003, 91: 137-142. PMID: 12521623, DOI: 10.1016/s0002-9149(02)03098-9.Peer-Reviewed Original ResearchConceptsBeta-Blocker Heart Attack TrialAcute myocardial infarctionHeart rate variabilityPlacebo-treated patientsHeart Attack TrialMyocardial infarctionEffect of propranololBeta blockersAttack TrialDepressed heart rate variabilityRate variabilityRecovery of HRVLF/HF ratioPropranolol-treated patientsWeeks of treatmentHF ratioHigh-frequency powerPropranolol therapyPropranolol treatmentSympathetic predominanceAutonomic toneParasympathetic toneSympathovagal balanceImproved outcomesSudden death