2024
Aberrant zonal recycling of germinal center B cells impairs appropriate selection in lupus
Sanchez G, Hirsch E, VanValkenburg A, Mayer D, Gbedande K, Francis R, Song W, Antao O, Brimmer K, Lemenze A, Stephens R, Johnson W, Weinstein J. Aberrant zonal recycling of germinal center B cells impairs appropriate selection in lupus. Cell Reports 2024, 43: 114978. PMID: 39527476, DOI: 10.1016/j.celrep.2024.114978.Peer-Reviewed Original ResearchGerminal centersB cellsDifferentiation of autoreactive B cellsLoss of MYCResponse to CD40 signalingPolyclonal B cell activationB cell dysregulationAccumulation of plasma cellsAutoreactive B cellsB cell activationGC B cellsB cell cycleProduction of autoantibodiesB cell signalingDecreased mutation frequencyRepertoire diversityPlasma cellsAutoimmune diseasesPersistent infectionCD40 signalingDisease progressionMutation frequencyReduced proliferationLupusLight zone
2023
Cutting Edge: IL-21 and Tissue-Specific Signals Instruct Tbet+CD11c+ B Cell Development following Viral Infection.
Song W, Sanchez G, Mayer D, Blackburn H, Chernova I, Flavell R, Weinstein J, Craft J. Cutting Edge: IL-21 and Tissue-Specific Signals Instruct Tbet+CD11c+ B Cell Development following Viral Infection. The Journal Of Immunology 2023, 210: 1861-1865. PMID: 37133336, PMCID: PMC10247523, DOI: 10.4049/jimmunol.2300027.Peer-Reviewed Original ResearchConceptsAge-associated B cellsIL-21Acute lymphocytic choriomeningitis virus infectionB cellsLymphocytic choriomeningitis virus infectionB cell activationHumoral immunityLymphoid organsVirus infectionMouse modelViral infectionB cell developmentCell activationLymphotoxin αVivo generationTissue-specific signalsInfectionDe novo generationOrgan contributionIFNTissue microenvironmentCell developmentLiverPivotal contributorStage-specific roles