2004
Major Molecular Differences between Mammalian Sexes Are Involved in Drug Metabolism and Renal Function
Rinn JL, Rozowsky JS, Laurenzi IJ, Petersen PH, Zou K, Zhong W, Gerstein M, Snyder M. Major Molecular Differences between Mammalian Sexes Are Involved in Drug Metabolism and Renal Function. Developmental Cell 2004, 6: 791-800. PMID: 15177028, DOI: 10.1016/j.devcel.2004.05.005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDNAFemaleGene Expression ProfilingGene Expression RegulationGenitaliaHumansHypothalamusKidneyLiverMaleMetabolic Clearance RateMiceOligonucleotide Array Sequence AnalysisOrgan SpecificityOvaryPharmaceutical PreparationsReceptors, Cell SurfaceSerpinsSex CharacteristicsTestisTranscortinConceptsMolecular differencesGene expressionExtensive differential gene expressionReproductive tissuesDifferential gene expressionGene expression differencesCellular rolesMammalian sexMouse geneMajor molecular differencesExpression differencesAdult tissuesOsmotic regulationExpression patternsFemale hypothalamusMolecular levelPhysiological differencesGenesDifferent hormonal environmentsRenal functionHormonal environmentExpressionSteroid metabolismMetabolismDrug metabolism
1997
Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis
Zhong W, Jiang M, Weinmaster G, Jan L, Jan Y. Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis. Development 1997, 124: 1887-1897. PMID: 9169836, DOI: 10.1242/dev.124.10.1887.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceCerebral CortexCloning, MolecularCytoplasmDrosophilaDrosophila ProteinsGene Expression Regulation, DevelopmentalGenesIntracellular Signaling Peptides and ProteinsJuvenile HormonesMembrane ProteinsMiceModels, NeurologicalMolecular Sequence DataMorphogenesisMutationNerve Tissue ProteinsNervous SystemNeuronsOrgan SpecificityReceptor, Notch1Receptors, Cell SurfaceRecombinant Fusion ProteinsRNA, MessengerSequence Homology, Amino AcidStem CellsTranscription FactorsConceptsDaughter cellsNeural precursorsMammalian cortical neurogenesisAsymmetric cell divisionSignificant sequence similarityMouse cortical neurogenesisCortical neurogenesisEmbryonic nervous systemFunction mutant embryosCell-cell interactionsCell-intrinsic mechanismsMammalian NumbMouse NumbNumb lossProgenitor cell proliferationDrosophila neurogenesisMammalian genesMutant embryosCell-extrinsic mechanismsSequence similarityCell divisionDifferential segregationNumblikePostmitotic neuronsNumb