2003
Diversifying Neural Cells through Order of Birth and Asymmetry of Division
Zhong W. Diversifying Neural Cells through Order of Birth and Asymmetry of Division. Neuron 2003, 37: 11-14. PMID: 12526768, DOI: 10.1016/s0896-6273(02)01178-9.Peer-Reviewed Original ResearchConceptsAsymmetry of divisionCell fate diversificationCell fate determinationAsymmetric cell divisionMature nervous systemFate diversificationDrosophila genesFate determinationCell divisionCell typesProgenitor cellsNeural cellsDevelopmental neurobiologyNervous systemCommon setCellsDivisionGenesDiversityDiversificationKey questions
2002
Progenitor cell maintenance requires numb and numblike during mouse neurogenesis
Petersen PH, Zou K, Hwang JK, Jan YN, Zhong W. Progenitor cell maintenance requires numb and numblike during mouse neurogenesis. Nature 2002, 419: 929-934. PMID: 12410312, DOI: 10.1038/nature01124.Peer-Reviewed Original ResearchConceptsMouse NumbNeural progenitor cellsMolecular mechanismsProgenitor cellsProgenitor cell maintenanceMammalian nervous systemOnset of neurogenesisConserved homologuesMutant embryosCourse of neurogenesisCell maintenanceMouse neurogenesisNeuronal fateNumbDividing cellsNeural cellsEarly neuronsNervous systemCritical roleProgenitorsCellsNeurogenesisDrosophilaTemporal patternsEmbryogenesis
1997
Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis
Zhong W, Jiang M, Weinmaster G, Jan L, Jan Y. Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis. Development 1997, 124: 1887-1897. PMID: 9169836, DOI: 10.1242/dev.124.10.1887.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceCerebral CortexCloning, MolecularCytoplasmDrosophilaDrosophila ProteinsGene Expression Regulation, DevelopmentalGenesIntracellular Signaling Peptides and ProteinsJuvenile HormonesMembrane ProteinsMiceModels, NeurologicalMolecular Sequence DataMorphogenesisMutationNerve Tissue ProteinsNervous SystemNeuronsOrgan SpecificityReceptor, Notch1Receptors, Cell SurfaceRecombinant Fusion ProteinsRNA, MessengerSequence Homology, Amino AcidStem CellsTranscription FactorsConceptsDaughter cellsNeural precursorsMammalian cortical neurogenesisAsymmetric cell divisionSignificant sequence similarityMouse cortical neurogenesisCortical neurogenesisEmbryonic nervous systemFunction mutant embryosCell-cell interactionsCell-intrinsic mechanismsMammalian NumbMouse NumbNumb lossProgenitor cell proliferationDrosophila neurogenesisMammalian genesMutant embryosCell-extrinsic mechanismsSequence similarityCell divisionDifferential segregationNumblikePostmitotic neuronsNumb