2005
Numb Proteins Specify Asymmetric Cell Fates via an Endocytosis- and Proteasome-Independent Pathway
Tang H, Rompani SB, Atkins JB, Zhou Y, Osterwalder T, Zhong W. Numb Proteins Specify Asymmetric Cell Fates via an Endocytosis- and Proteasome-Independent Pathway. Molecular And Cellular Biology 2005, 25: 2899-2909. PMID: 15798180, PMCID: PMC1069617, DOI: 10.1128/mcb.25.8.2899-2909.2005.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsAmino Acid SequenceAnimalsCell DivisionDrosophila melanogasterDrosophila ProteinsEndocytosisJuvenile HormonesMembrane ProteinsMiceMolecular Sequence DataNerve Tissue ProteinsNeuropeptidesProteasome Endopeptidase ComplexProteasome InhibitorsReceptors, NotchSignal TransductionTwo-Hybrid System TechniquesVesicular Transport ProteinsConceptsNumb proteinProteasome-independent pathwayAsymmetric cell fate specificationAsymmetric cell fatesCell fate specificationEps15 homology (EH) domainE3 ubiquitin ligasesNotch protein levelsCell-cell communicationAlpha-adaptinFate specificationEndocytic proteinsDistinct binding motifsDrosophila melanogasterAsymmetric divisionCell fateHomology domainUbiquitin ligasesDaughter cellsNotch activityBinding motifEndocytosisHomologue 1Proteasome activityCell surface
2003
Diversifying Neural Cells through Order of Birth and Asymmetry of Division
Zhong W. Diversifying Neural Cells through Order of Birth and Asymmetry of Division. Neuron 2003, 37: 11-14. PMID: 12526768, DOI: 10.1016/s0896-6273(02)01178-9.Peer-Reviewed Original ResearchConceptsAsymmetry of divisionCell fate diversificationCell fate determinationAsymmetric cell divisionMature nervous systemFate diversificationDrosophila genesFate determinationCell divisionCell typesProgenitor cellsNeural cellsDevelopmental neurobiologyNervous systemCommon setCellsDivisionGenesDiversityDiversificationKey questions
2002
Progenitor cell maintenance requires numb and numblike during mouse neurogenesis
Petersen PH, Zou K, Hwang JK, Jan YN, Zhong W. Progenitor cell maintenance requires numb and numblike during mouse neurogenesis. Nature 2002, 419: 929-934. PMID: 12410312, DOI: 10.1038/nature01124.Peer-Reviewed Original ResearchConceptsMouse NumbNeural progenitor cellsMolecular mechanismsProgenitor cellsProgenitor cell maintenanceMammalian nervous systemOnset of neurogenesisConserved homologuesMutant embryosCourse of neurogenesisCell maintenanceMouse neurogenesisNeuronal fateNumbDividing cellsNeural cellsEarly neuronsNervous systemCritical roleProgenitorsCellsNeurogenesisDrosophilaTemporal patternsEmbryogenesis
1997
Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis
Zhong W, Jiang M, Weinmaster G, Jan L, Jan Y. Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis. Development 1997, 124: 1887-1897. PMID: 9169836, DOI: 10.1242/dev.124.10.1887.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceCerebral CortexCloning, MolecularCytoplasmDrosophilaDrosophila ProteinsGene Expression Regulation, DevelopmentalGenesIntracellular Signaling Peptides and ProteinsJuvenile HormonesMembrane ProteinsMiceModels, NeurologicalMolecular Sequence DataMorphogenesisMutationNerve Tissue ProteinsNervous SystemNeuronsOrgan SpecificityReceptor, Notch1Receptors, Cell SurfaceRecombinant Fusion ProteinsRNA, MessengerSequence Homology, Amino AcidStem CellsTranscription FactorsConceptsDaughter cellsNeural precursorsMammalian cortical neurogenesisAsymmetric cell divisionSignificant sequence similarityMouse cortical neurogenesisCortical neurogenesisEmbryonic nervous systemFunction mutant embryosCell-cell interactionsCell-intrinsic mechanismsMammalian NumbMouse NumbNumb lossProgenitor cell proliferationDrosophila neurogenesisMammalian genesMutant embryosCell-extrinsic mechanismsSequence similarityCell divisionDifferential segregationNumblikePostmitotic neuronsNumb
1996
Asymmetric Localization of a Mammalian Numb Homolog during Mouse Cortical Neurogenesis
Zhong W, Feder J, Jiang M, Jan L, Jan Y. Asymmetric Localization of a Mammalian Numb Homolog during Mouse Cortical Neurogenesis. Neuron 1996, 17: 43-53. PMID: 8755477, DOI: 10.1016/s0896-6273(00)80279-2.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCell DivisionCell MembraneCerebral CortexDrosophilaDrosophila ProteinsEmbryo, MammalianEmbryo, NonmammalianEmbryonic and Fetal DevelopmentJuvenile HormonesMembrane ProteinsMiceMolecular Sequence DataMutationNeuronsRatsReceptors, Cell SurfaceReceptors, NotchSequence Homology, Amino AcidTissue DistributionConceptsMouse cortical neurogenesisDaughter cellsAsymmetric cell divisionCortical neurogenesisCell-cell interactionsDrosophila neurogenesisMammalian homologMutant phenotypeMouse Notch1Drosophila embryosDistinct fatesDrosophila NumbAsymmetric divisionAsymmetric localizationCell divisionDifferential segregationMolecular mechanismsNeural progenitorsNumbNeural precursorsApical membraneHomologNeurogenesisInvertebratesVertebrates