2008
Timing cell-fate determination during asymmetric cell divisions
Zhong W. Timing cell-fate determination during asymmetric cell divisions. Current Opinion In Neurobiology 2008, 18: 472-478. PMID: 18983918, PMCID: PMC2609754, DOI: 10.1016/j.conb.2008.10.005.Peer-Reviewed Original ResearchConceptsAsymmetric cell divisionCell divisionCell cycle progressionFate determinantsCell fate determinantsCell fate determinationCell fateDaughter cellsCellular organellesMolecular mechanismsCell cycleGolgi apparatusIntracellular signalingSubcellular distributionDifferent fatesCell typesNovel mechanismCell proliferationMolecular compositionMultiple roundsRecent findingsDivisionFateInvertebratesCentrosomesNeurogenesis and asymmetric cell division
Zhong W, Chia W. Neurogenesis and asymmetric cell division. Current Opinion In Neurobiology 2008, 18: 4-11. PMID: 18513950, DOI: 10.1016/j.conb.2008.05.002.Peer-Reviewed Original ResearchConceptsNeural progenitor cellsAsymmetric divisionMammalian neural progenitor cellsAsymmetric cell divisionProgenitor cellsCellular diversityGlial progenyCell divisionCell biologyNeuronal lineageNeural progenitorsCentral nervous systemDivisionNeurogenesisDrosophilaVertebratesCellsLineagesNervous systemBiologyProgenyProgenitorsDiversityNeuroblastsSimilarity
2007
The Mammalian Golgi Regulates Numb Signaling in Asymmetric Cell Division by Releasing ACBD3 during Mitosis
Zhou Y, Atkins JB, Rompani SB, Bancescu DL, Petersen PH, Tang H, Zou K, Stewart SB, Zhong W. The Mammalian Golgi Regulates Numb Signaling in Asymmetric Cell Division by Releasing ACBD3 during Mitosis. Cell 2007, 129: 163-178. PMID: 17418793, DOI: 10.1016/j.cell.2007.02.037.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAnimals, Genetically ModifiedCell DivisionCell LineageCytosolDrosophilaEmbryo, MammalianEmbryo, NonmammalianEmbryonic DevelopmentGolgi ApparatusMembrane ProteinsMiceMitosisNerve Tissue ProteinsNeuronsPhenotypeProtein Structure, TertiaryReceptors, GABA-ASignal TransductionStem CellsConceptsCell fate specificationNumb proteinDaughter cellsGolgi fragmentationCell cycleMammalian neural progenitor cellsAsymmetric cell divisionProgenitor cell cycleProgenitor cellsCell cycle progressionNeural progenitor cellsMammalian GolgiCell fateCell divisionNeuronal fateACBD3Golgi apparatusSubcellular distributionNeuronal differentiationPhenotypic similarityNumbMitosisNeuron productionProteinCells
2006
The Enigma of the Numb-Notch Relationship during Mammalian Embryogenesis
Petersen PH, Tang H, Zou K, Zhong W. The Enigma of the Numb-Notch Relationship during Mammalian Embryogenesis. Developmental Neuroscience 2006, 28: 156-168. PMID: 16508312, DOI: 10.1159/000090761.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody PatterningCell DifferentiationCell DivisionCell LineageDrosophila melanogasterEmbryo, MammalianEmbryo, NonmammalianEmbryonic DevelopmentGene Expression Regulation, DevelopmentalGenes, HomeoboxMammalsMembrane ProteinsMesodermMiceMice, Mutant StrainsMutationNerve Tissue ProteinsProtein IsoformsReceptors, NotchSomitesStem CellsConceptsAsymmetric cell divisionAntagonistic rolesCell divisionCell fate specificationStem cell maintenanceDefective Notch signalingEmbryonic nervous systemStem/progenitor cellsMammalian embryogenesisNeural stem/progenitor cellsFate specificationCell fateNumb proteinCell maintenanceNumb isoformsMammalian neurogenesisMolecular basisNotch signalingDifferent fatesNumbDifferential regulationStem cellsProgenitor cellsEmbryogenesisPremature depletion
2005
Numb Proteins Specify Asymmetric Cell Fates via an Endocytosis- and Proteasome-Independent Pathway
Tang H, Rompani SB, Atkins JB, Zhou Y, Osterwalder T, Zhong W. Numb Proteins Specify Asymmetric Cell Fates via an Endocytosis- and Proteasome-Independent Pathway. Molecular And Cellular Biology 2005, 25: 2899-2909. PMID: 15798180, PMCID: PMC1069617, DOI: 10.1128/mcb.25.8.2899-2909.2005.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsAmino Acid SequenceAnimalsCell DivisionDrosophila melanogasterDrosophila ProteinsEndocytosisJuvenile HormonesMembrane ProteinsMiceMolecular Sequence DataNerve Tissue ProteinsNeuropeptidesProteasome Endopeptidase ComplexProteasome InhibitorsReceptors, NotchSignal TransductionTwo-Hybrid System TechniquesVesicular Transport ProteinsConceptsNumb proteinProteasome-independent pathwayAsymmetric cell fate specificationAsymmetric cell fatesCell fate specificationEps15 homology (EH) domainE3 ubiquitin ligasesNotch protein levelsCell-cell communicationAlpha-adaptinFate specificationEndocytic proteinsDistinct binding motifsDrosophila melanogasterAsymmetric divisionCell fateHomology domainUbiquitin ligasesDaughter cellsNotch activityBinding motifEndocytosisHomologue 1Proteasome activityCell surface
2003
Diversifying Neural Cells through Order of Birth and Asymmetry of Division
Zhong W. Diversifying Neural Cells through Order of Birth and Asymmetry of Division. Neuron 2003, 37: 11-14. PMID: 12526768, DOI: 10.1016/s0896-6273(02)01178-9.Peer-Reviewed Original ResearchConceptsAsymmetry of divisionCell fate diversificationCell fate determinationAsymmetric cell divisionMature nervous systemFate diversificationDrosophila genesFate determinationCell divisionCell typesProgenitor cellsNeural cellsDevelopmental neurobiologyNervous systemCommon setCellsDivisionGenesDiversityDiversificationKey questions
2002
Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts.
Shen Q, Zhong W, Jan YN, Temple S. Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts. Development 2002, 129: 4843-53. PMID: 12361975, DOI: 10.1242/dev.129.20.4843.Peer-Reviewed Original ResearchConceptsAsymmetric cell divisionCell divisionMouse cortical developmentCell fateStem cellsProgenitor cellsDiverse cell fatesNeural cell fateMouse cortical neurogenesisNext cell divisionEmbryonic mouse cortexDrosophila neurogenesisProgenitor marker nestinAsymmetric segregationLineage treesNumb proteinCortical stem cellsMouse homologueNotch activityWild typeNumbNeuronal differentiationNeuronal cellsCortical neurogenesisCortical developmentProgenitor cell maintenance requires numb and numblike during mouse neurogenesis
Petersen PH, Zou K, Hwang JK, Jan YN, Zhong W. Progenitor cell maintenance requires numb and numblike during mouse neurogenesis. Nature 2002, 419: 929-934. PMID: 12410312, DOI: 10.1038/nature01124.Peer-Reviewed Original ResearchConceptsMouse NumbNeural progenitor cellsMolecular mechanismsProgenitor cellsProgenitor cell maintenanceMammalian nervous systemOnset of neurogenesisConserved homologuesMutant embryosCourse of neurogenesisCell maintenanceMouse neurogenesisNeuronal fateNumbDividing cellsNeural cellsEarly neuronsNervous systemCritical roleProgenitorsCellsNeurogenesisDrosophilaTemporal patternsEmbryogenesis
1996
Asymmetric Localization of a Mammalian Numb Homolog during Mouse Cortical Neurogenesis
Zhong W, Feder J, Jiang M, Jan L, Jan Y. Asymmetric Localization of a Mammalian Numb Homolog during Mouse Cortical Neurogenesis. Neuron 1996, 17: 43-53. PMID: 8755477, DOI: 10.1016/s0896-6273(00)80279-2.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCell DivisionCell MembraneCerebral CortexDrosophilaDrosophila ProteinsEmbryo, MammalianEmbryo, NonmammalianEmbryonic and Fetal DevelopmentJuvenile HormonesMembrane ProteinsMiceMolecular Sequence DataMutationNeuronsRatsReceptors, Cell SurfaceReceptors, NotchSequence Homology, Amino AcidTissue DistributionConceptsMouse cortical neurogenesisDaughter cellsAsymmetric cell divisionCortical neurogenesisCell-cell interactionsDrosophila neurogenesisMammalian homologMutant phenotypeMouse Notch1Drosophila embryosDistinct fatesDrosophila NumbAsymmetric divisionAsymmetric localizationCell divisionDifferential segregationMolecular mechanismsNeural progenitorsNumbNeural precursorsApical membraneHomologNeurogenesisInvertebratesVertebrates