1994
Tissue-specific regulation of mouse hepatocyte nuclear factor 4 expression.
Zhong W, Mirkovitch J, Darnell J. Tissue-specific regulation of mouse hepatocyte nuclear factor 4 expression. Molecular And Cellular Biology 1994, 14: 7276-7284. PMID: 7523862, PMCID: PMC359262, DOI: 10.1128/mcb.14.11.7276.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBinding SitesDeoxyribonuclease IDNA ProbesDNA-Binding ProteinsGene Expression RegulationHepatocyte Nuclear Factor 4KidneyLiverLiver Neoplasms, ExperimentalMiceMice, TransgenicMolecular Sequence DataPhosphoproteinsPromoter Regions, GeneticRNATissue DistributionTranscription FactorsTransfectionTumor Cells, CulturedConceptsTransient transfection assaysLiver-enriched transcription factorsHNF-4HNF-4 geneLiver-specific expressionTranscription factorsPresence of DNase I-hypersensitive sitesHNF-1 binding siteDNase I hypersensitive sitesHepatocyte nuclear factor 4Distal enhancer elementsDNase hypersensitive sitesHepatoma-specific expressionSteroid hormone receptor superfamilyHNF-4 expressionTissue-specific expressionHNF-1 alphaHormone receptor superfamilyExpression of HNF-4RNA startDNA elementsEnhancer elementsHNF-1Promoter regionReporter constructsTissue-Specific Regulation of Mouse Hepatocyte Nuclear Factor 4 Expression
Zhong W, Mirkovitch J, Darnell J. Tissue-Specific Regulation of Mouse Hepatocyte Nuclear Factor 4 Expression. Molecular And Cellular Biology 1994, 14: 7276-7284. DOI: 10.1128/mcb.14.11.7276-7284.1994.Peer-Reviewed Original ResearchTransient transfection assaysLiver-enriched transcription factorsHNF-4HNF-4 geneLiver-specific expressionTranscription factorsPresence of DNase I-hypersensitive sitesHNF-1 binding siteDNase I hypersensitive sitesHepatocyte nuclear factor 4RNA start siteDistal enhancer elementsDNase hypersensitive sitesHepatoma-specific expressionSteroid hormone receptor superfamilyHNF-4 expressionTissue-specific expressionHormone receptor superfamilyExpression of HNF-4DNA elementsStart siteEnhancer elementsHNF-1Promoter regionHNF-1A
1992
Murine chromosomal location of four hepatocyte-enriched transcription factors: HNf-3α, HNF-3β, HNF-3γ, and HNF-4
Avraham K, Prezioso V, Chen W, Lai E, Sladek F, Zhong W, Darnell J, Jenkins N, Copeland N. Murine chromosomal location of four hepatocyte-enriched transcription factors: HNf-3α, HNF-3β, HNF-3γ, and HNF-4. Genomics 1992, 13: 264-268. PMID: 1612587, DOI: 10.1016/0888-7543(92)90241-j.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsChromosome MappingCrosses, GeneticDigestive SystemDNA-Binding ProteinsGene Expression RegulationGenetic MarkersHepatocyte Nuclear Factor 3-alphaHepatocyte Nuclear Factor 3-betaHepatocyte Nuclear Factor 3-gammaHepatocyte Nuclear Factor 4HumansMiceMice, Inbred C57BLMuridaeNuclear ProteinsPhosphoproteinsSpecies SpecificityTranscription FactorsConceptsHNF-3 familyHepatocyte-enriched transcription factorsHNF-3Transcription factorsHNF-4Positive-acting transcription factorsHepatocyte nuclear factor 3Analysis of restriction fragment length polymorphismsInterspecific backcross miceDNA-binding domainHNF-3 alphaRestriction fragment length polymorphismFragment length polymorphismDrosophila genesChromosomal locationMouse chromosomeRegulatory regionsHNF-3BBinding domainBackcross miceLength polymorphismEndoderm developmentGut cellsGenesBinding sites
1990
Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily.
Sladek F, Zhong W, Lai E, Darnell J. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes & Development 1990, 4: 2353-2365. PMID: 2279702, DOI: 10.1101/gad.4.12b.2353.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBinding SitesCell NucleusCloning, MolecularDNA-Binding ProteinsGene ExpressionHepatocyte Nuclear Factor 4LiverMacromolecular SubstancesMaleMolecular Sequence DataMultigene FamilyOligonucleotide ProbesPhosphoproteinsRatsRats, Inbred StrainsReceptors, SteroidRecombinant ProteinsSequence Homology, Nucleic AcidTranscription FactorsTranscription, GeneticConceptsSteroid hormone receptor superfamilyHNF-4 proteinHNF-4Hormone receptor superfamilyReceptor superfamilyTranscription factor HNF-4Regulation of transcriptionAmino acid sequencePyruvate kinase geneLigand-dependent transcription factorSequence-specific fashionDNA binding activityPolymerase chain reactionHNF-4 mRNANorthern blot analysisUnusual amino acidsLF-A1CDNA clonesActivate transcriptionBinding to sitesZinc fingerCotransfection assaysDNA bindingSynthetic oligonucleotidesTranscription factors