2018
A Latent Variable Approach to Differentiating Neural Mechanisms of Irritability and Anxiety in Youth
Kircanski K, White LK, Tseng WL, Wiggins JL, Frank HR, Sequeira S, Zhang S, Abend R, Towbin KE, Stringaris A, Pine DS, Leibenluft E, Brotman MA. A Latent Variable Approach to Differentiating Neural Mechanisms of Irritability and Anxiety in Youth. JAMA Psychiatry 2018, 75: 631-639. PMID: 29625429, PMCID: PMC6137523, DOI: 10.1001/jamapsychiatry.2018.0468.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaAnxietyAttention Deficit Disorder with HyperactivityBrainCase-Control StudiesCaudate NucleusCerebral CortexChildCross-Sectional StudiesFemaleFunctional NeuroimagingHumansIrritable MoodLatent Class AnalysisMagnetic Resonance ImagingMaleMood DisordersNeural PathwaysParietal LobePrefrontal CortexConceptsParent-reported irritabilityNeural mechanismsAnxiety symptomsLatent variable approachPediatric irritabilityNeural correlatesAmygdala connectivityShared varianceCross-sectional functional magnetic resonance imaging studyNeural activityFunctional magnetic resonance imaging studyDot-probe taskAffective Reactivity IndexVentrolateral prefrontal cortexCommon neural mechanismsAmygdala functional connectivityFunctional magnetic resonanceLevels of irritabilityWhole-brain analysisInferior parietal lobuleData-driven phenotypingMultiple diagnostic categoriesCo-occurring symptomsMagnetic resonance imaging studyNeutral faces
2016
Functional connectivity during masked and unmasked face emotion processing in bipolar disorder
Tseng WL, Thomas LA, Harkins E, Stoddard J, Zarate CA, Pine DS, Leibenluft E, Brotman MA. Functional connectivity during masked and unmasked face emotion processing in bipolar disorder. Psychiatry Research Neuroimaging 2016, 258: 1-9. PMID: 27814457, PMCID: PMC5135603, DOI: 10.1016/j.pscychresns.2016.10.006.Peer-Reviewed Original ResearchConceptsFace emotion processingEmotion processingHealthy volunteersBipolar disorderFunctional connectivityAffective priming taskAmygdala-vmPFC connectivityVentromedial prefrontal cortexExpression of emotionsBD patientsMedial frontal gyrusNeutral facesPriming taskEmotion typeEmotional processingFMRI scanningActivation differencesFrontal gyrusGreater activationLess activationPrefrontal cortexConnectivity findingsNeural connectivityPathophysiological correlatesNeural dysfunction
2013
Fronto-limbic-striatal dysfunction in pediatric and adult patients with bipolar disorder: impact of face emotion and attentional demands
Brotman MA, Tseng WL, Olsavsky AK, Fromm SJ, Muhrer EJ, Rutenberg JG, Deveney CM, Adleman NE, Zarate CA, Pine DS, Leibenluft E. Fronto-limbic-striatal dysfunction in pediatric and adult patients with bipolar disorder: impact of face emotion and attentional demands. Psychological Medicine 2013, 44: 1639-1651. PMID: 23930595, PMCID: PMC3922892, DOI: 10.1017/s003329171300202x.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexFunctional magnetic resonance imagingNeutral facesInferior frontal gyrusTask demandsImplicit processingHappy facesPassive viewingAmygdala hyperactivationCognitive control circuitsFace emotion processingBipolar disorderPediatric bipolar disorderHealthy comparison subjectsExplicit processingFamily-wise errorFearful facesAttentional conditionsFace emotionsAttentional demandsEmotion processingFrontal gyrusCingulate cortexHypoactivationComparison subjects