2024
Associations Between Neighborhood Resources and Youth’s Response to Reward Omission in a Task Modeling Negatively Biased Environments
Brown B, Nguyen L, Morales I, Cardinale E, Tseng W, McKay C, Kircanski K, Brotman M, Pine D, Leibenluft E, Linke J. Associations Between Neighborhood Resources and Youth’s Response to Reward Omission in a Task Modeling Negatively Biased Environments. Journal Of The American Academy Of Child & Adolescent Psychiatry 2024 PMID: 38763411, DOI: 10.1016/j.jaac.2024.05.011.Peer-Reviewed Original ResearchChildhood Opportunity IndexPaper self-identifiesNeighborhood resourcesAbstractText Label="DIVERSITY &Functional magnetic resonance imagingAbstractText Label="METHOD" NlmCategory="METHODS">Ethnic groupsReward omissionBlocked goalsNeurobiological levelMood disordersNeurodevelopmental trajectoriesLocal processing modeMental healthReduced connectivityDiverse sampleInvestigate associationsControl networkNeighborhood featuresQuantify accessProvincial hubsPromote sexRewardOpportunity IndexMagnetic resonance imaging
2022
Persistent Frustration-Induced Reconfigurations of Brain Networks Predict Individual Differences in Irritability
Linke J, Haller S, Xu E, Nguyen L, Chue A, Botz-Zapp C, Revzina O, Perlstein S, Ross A, Tseng W, Shaw P, Brotman M, Pine D, Gotts S, Leibenluft E, Kircanski K. Persistent Frustration-Induced Reconfigurations of Brain Networks Predict Individual Differences in Irritability. Journal Of The American Academy Of Child & Adolescent Psychiatry 2022, 62: 684-695. PMID: 36563874, PMCID: PMC11224120, DOI: 10.1016/j.jaac.2022.11.009.Peer-Reviewed Original ResearchConceptsResting-state scansPathophysiology of irritabilitySelf-reported irritabilityFunctional magnetic resonance imagingMagnetic resonance imagingParent-reported irritabilitySpecific intervention targetsRisk factorsMotor functionPsychiatric consultationCircuit reorganizationCommon reasonAffective disordersBrain network configurationIrritability symptomsResonance imagingBrain regionsIrritabilityCentral mechanismsAberrant responsesPilot studyIntervention targetsRecovery periodPediatric irritabilityBrain networksSystematic Review and Meta-analysis: Task-based fMRI Studies in Youths With Irritability
Lee KS, Hagan CN, Hughes M, Cotter G, Freud E, Kircanski K, Leibenluft E, Brotman MA, Tseng WL. Systematic Review and Meta-analysis: Task-based fMRI Studies in Youths With Irritability. Journal Of The American Academy Of Child & Adolescent Psychiatry 2022, 62: 208-229. PMID: 35944754, PMCID: PMC9892288, DOI: 10.1016/j.jaac.2022.05.014.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingFMRI studyNeurocognitive functionNeural convergenceActivation likelihood estimationLow frustration toleranceIrritability measuresFrequent temper tantrumsSample characteristicsCognitive controlFMRI taskEmotional reactivityStimulus typeFMRI resultsChildhood irritabilityFrustration toleranceNeural mechanismsFunctional neuroimagingTransdiagnostic symptomsTask domainTemper tantrumsFMRI methodsNeuroscience databasesNull findingsCoordinate-based data
2017
Association of Irritability and Anxiety With the Neural Mechanisms of Implicit Face Emotion Processing in Youths With Psychopathology
Stoddard J, Tseng WL, Kim P, Chen G, Yi J, Donahue L, Brotman MA, Towbin KE, Pine DS, Leibenluft E. Association of Irritability and Anxiety With the Neural Mechanisms of Implicit Face Emotion Processing in Youths With Psychopathology. JAMA Psychiatry 2017, 74: 95-103. PMID: 27902832, PMCID: PMC6309540, DOI: 10.1001/jamapsychiatry.2016.3282.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaAnxiety DisordersArousalAttention Deficit Disorder with HyperactivityBrainChildCross-Sectional StudiesDominance, CerebralEmotionsFacial RecognitionFemaleHumansIrritable MoodMagnetic Resonance ImagingMaleMental DisordersMood DisordersNerve NetPrefrontal CortexPsychopathologyConceptsFunctional magnetic resonance imagingPrefrontal cortex connectivityFace emotionsNeural responsesCortex connectivityMedial prefrontal cortex connectivityAttention-deficit/hyperactivity disorderChild Anxiety Related DisordersThreat-related facesDisruptive Mood DysregulationPathophysiology of irritabilityFace emotion processingAmygdala-medial prefrontal cortex connectivityCross-sectional functional magnetic resonanceAffective Reactivity IndexBrain-behavior relationshipsVentral visual areasAssociations of irritabilityUnique effectsAmygdala functional connectivityAnxiety Related DisordersFunctional magnetic resonanceYouth ages 8Angry facesFearful faces
2015
Neural correlates of masked and unmasked face emotion processing in youth with severe mood dysregulation
Tseng WL, Thomas LA, Harkins E, Pine DS, Leibenluft E, Brotman MA. Neural correlates of masked and unmasked face emotion processing in youth with severe mood dysregulation. Social Cognitive And Affective Neuroscience 2015, 11: 78-88. PMID: 26137973, PMCID: PMC4692312, DOI: 10.1093/scan/nsv087.Peer-Reviewed Original ResearchConceptsSevere mood dysregulationFace emotion processingFunctional magnetic resonance imagingEmotion processingParahippocampal gyrusNeural correlatesMood dysregulationVentromedial prefrontal cortex activationAffective priming paradigmPrefrontal cortex activationSuperior temporal gyrusAngry facesFace processingHappy facesSMD patientsPositive emotionsPriming paradigmVmPFC dysfunctionNegative emotionsTemporal gyrusCortex activationEmotionsFMRI dataDecreased activationIndependent samples
2013
Fronto-limbic-striatal dysfunction in pediatric and adult patients with bipolar disorder: impact of face emotion and attentional demands
Brotman MA, Tseng WL, Olsavsky AK, Fromm SJ, Muhrer EJ, Rutenberg JG, Deveney CM, Adleman NE, Zarate CA, Pine DS, Leibenluft E. Fronto-limbic-striatal dysfunction in pediatric and adult patients with bipolar disorder: impact of face emotion and attentional demands. Psychological Medicine 2013, 44: 1639-1651. PMID: 23930595, PMCID: PMC3922892, DOI: 10.1017/s003329171300202x.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexFunctional magnetic resonance imagingNeutral facesInferior frontal gyrusTask demandsImplicit processingHappy facesPassive viewingAmygdala hyperactivationCognitive control circuitsFace emotion processingBipolar disorderPediatric bipolar disorderHealthy comparison subjectsExplicit processingFamily-wise errorFearful facesAttentional conditionsFace emotionsAttentional demandsEmotion processingFrontal gyrusCingulate cortexHypoactivationComparison subjects