2020
A preliminary study on functional activation and connectivity during frustration in youths with bipolar disorder
Ross AJ, Roule AL, Deveney CM, Towbin KE, Brotman MA, Leibenluft E, Tseng W. A preliminary study on functional activation and connectivity during frustration in youths with bipolar disorder. Bipolar Disorders 2020, 23: 263-273. PMID: 32790927, PMCID: PMC8074834, DOI: 10.1111/bdi.12985.Peer-Reviewed Original ResearchConceptsInferior frontal gyrusFeedback processingBD youthNeural responsesReward-relevant stimuliFunctional activationSelf-reported frustrationSelf-reported affectAtypical activation patternsGoal-directed behaviorPrefrontal cortex connectivityBipolar disorderBipolar disorder youthAttentional abilitiesAttention taskImpaired attentionFMRI paradigmTask performanceFrontal gyrusAttention networkGreater recruitmentCortex connectivityGreater unhappinessIrritability symptomsInterest activation
2016
Functional connectivity during masked and unmasked face emotion processing in bipolar disorder
Tseng WL, Thomas LA, Harkins E, Stoddard J, Zarate CA, Pine DS, Leibenluft E, Brotman MA. Functional connectivity during masked and unmasked face emotion processing in bipolar disorder. Psychiatry Research Neuroimaging 2016, 258: 1-9. PMID: 27814457, PMCID: PMC5135603, DOI: 10.1016/j.pscychresns.2016.10.006.Peer-Reviewed Original ResearchConceptsFace emotion processingEmotion processingHealthy volunteersBipolar disorderFunctional connectivityAffective priming taskAmygdala-vmPFC connectivityVentromedial prefrontal cortexExpression of emotionsBD patientsMedial frontal gyrusNeutral facesPriming taskEmotion typeEmotional processingFMRI scanningActivation differencesFrontal gyrusGreater activationLess activationPrefrontal cortexConnectivity findingsNeural connectivityPathophysiological correlatesNeural dysfunction
2015
BEHAVIOR AND EMOTION MODULATION DEFICITS IN PRESCHOOLERS AT RISK FOR BIPOLAR DISORDER
Tseng W, Guyer AE, Briggs‐Gowan M, Axelson D, Birmaher B, Egger HL, Helm J, Stowe Z, Towbin KA, Wakschlag LS, Leibenluft E, Brotman MA. BEHAVIOR AND EMOTION MODULATION DEFICITS IN PRESCHOOLERS AT RISK FOR BIPOLAR DISORDER. Depression And Anxiety 2015, 32: 325-334. PMID: 25691090, PMCID: PMC4409452, DOI: 10.1002/da.22342.Peer-Reviewed Original ResearchConceptsBipolar disorderAppropriate clinical assessment toolFamilial riskLow-risk groupFirst-degree relativesClinical assessment toolHigh familial riskStandardized laboratory observationsOppositional defiant disorderFamily historyMood disordersModulation deficitsLower riskProdromal indicatorsPsychiatric assessmentChild Behavior ChecklistEarly interventionAnger modulationDefiant disorderDisordersLarge longitudinal sampleHigh-risk preschoolersBehavior ChecklistRiskEmotional problemsAn fMRI study of emotional face encoding in youth at risk for bipolar disorder
Tseng W, Bones BL, Kayser RR, Olsavsky AK, Fromm SJ, Pine DS, Leibenluft E, Brotman MA. An fMRI study of emotional face encoding in youth at risk for bipolar disorder. European Psychiatry 2015, 30: 94-98. PMID: 25172156, PMCID: PMC10656053, DOI: 10.1016/j.eurpsy.2014.05.004.Peer-Reviewed Original Research
2013
Fronto-limbic-striatal dysfunction in pediatric and adult patients with bipolar disorder: impact of face emotion and attentional demands
Brotman MA, Tseng WL, Olsavsky AK, Fromm SJ, Muhrer EJ, Rutenberg JG, Deveney CM, Adleman NE, Zarate CA, Pine DS, Leibenluft E. Fronto-limbic-striatal dysfunction in pediatric and adult patients with bipolar disorder: impact of face emotion and attentional demands. Psychological Medicine 2013, 44: 1639-1651. PMID: 23930595, PMCID: PMC3922892, DOI: 10.1017/s003329171300202x.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexFunctional magnetic resonance imagingNeutral facesInferior frontal gyrusTask demandsImplicit processingHappy facesPassive viewingAmygdala hyperactivationCognitive control circuitsFace emotion processingBipolar disorderPediatric bipolar disorderHealthy comparison subjectsExplicit processingFamily-wise errorFearful facesAttentional conditionsFace emotionsAttentional demandsEmotion processingFrontal gyrusCingulate cortexHypoactivationComparison subjects