Pla2g12b drives expansion of triglyceride-rich lipoproteins
Thierer J, Foresti O, Yadav P, Wilson M, Moll T, Shen M, Busch-Nentwich E, Morash M, Mohlke K, Rawls J, Malhotra V, Hussain M, Farber S. Pla2g12b drives expansion of triglyceride-rich lipoproteins. Nature Communications 2024, 15: 2095. PMID: 38453914, PMCID: PMC10920679, DOI: 10.1038/s41467-024-46102-4.Peer-Reviewed Original ResearchConceptsEndoplasmic reticulumAccumulation of intracellular lipidsSubcellular localizationTriglyceride-rich lipoproteinsEvolutionary tradeoffsInteraction partnersNascent lipoproteinsFunctional domainsLipoprotein homeostasisPLA2G12BIntracellular lipidsResistant to atherosclerosisMutant miceVertebratesReticulumTriglyceride incorporationLipid secretionCardiovascular disease riskCalcium-dependentExcessive accumulationDisease riskTriglyceride transportLipoproteinTriglyceridesLipid