2008
Early involvement of synapsin III in neural progenitor cell development in the adult hippocampus
Kao H, Li P, Chao HM, Janoschka S, Pham K, Feng J, Mcewen BS, Greengard P, Pieribone VA, Porton B. Early involvement of synapsin III in neural progenitor cell development in the adult hippocampus. The Journal Of Comparative Neurology 2008, 507: 1860-1870. PMID: 18271024, DOI: 10.1002/cne.21643.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsBiomarkersCell DifferentiationCell ProliferationCell SurvivalDentate GyrusDNA-Binding ProteinsFemaleFluorescent Antibody TechniqueIntermediate Filament ProteinsMaleMiceMice, Inbred C57BLMice, KnockoutNerve Growth FactorsNerve Tissue ProteinsNestinNeural Cell Adhesion Molecule L1Neuronal PlasticityNeuronsNuclear ProteinsSialic AcidsStem CellsSynapsinsTime FactorsTubulinConceptsHippocampal dentate gyrusWild-type miceAdult hippocampal dentate gyrusNeural progenitor cellsDentate gyrusNeural progenitor cell developmentProgenitor cellsProgenitor cell developmentSynapsin IIISynaptic vesicle-associated proteinsCell developmentSubgranular layerAdult neurogenesisKnockout miceSynaptic vesicle proteinsVesicle-associated proteinBrain regionsGyrusMiceNeurogenesisEarly involvementMarker of mitosisNovel roleVesicle proteinsProliferation
2007
Clinical Evaluation of Ganaxolone in Pediatric and Adolescent Patients with Refractory Epilepsy
Pieribone VA, Tsai J, Soufflet C, Rey E, Shaw K, Giller E, Dulac O. Clinical Evaluation of Ganaxolone in Pediatric and Adolescent Patients with Refractory Epilepsy. Epilepsia 2007, 48: 1870-1874. PMID: 17634060, DOI: 10.1111/j.1528-1167.2007.01182.x.Peer-Reviewed Original ResearchConceptsRefractory epilepsyAdverse eventsPilot studyDose escalation scheduleExtension periodDose-escalation trialEscalation scheduleSubstantial respondersAntiepileptic therapyTreat analysisGeneralized epilepsyModerate respondersAdolescent patientsClinical evaluationGanaxoloneClinical studiesPediatric subjectsPotential efficacyAnticonvulsant activityEpilepsyAdolescent subjectsOral suspensionExtension phaseDose rangeFurther studies