2023
Hospital-acquired venous thromboembolism during invasive mechanical ventilation in children: a single-center, retrospective cohort study
Havlicek E, Goldman Z, Faustino E, Ignjatovic V, Goldenberg N, Sochet A. Hospital-acquired venous thromboembolism during invasive mechanical ventilation in children: a single-center, retrospective cohort study. Journal Of Thrombosis And Haemostasis 2023, 21: 3145-3152. PMID: 37423387, DOI: 10.1016/j.jtha.2023.06.035.Peer-Reviewed Original ResearchMeSH KeywordsAnticoagulantsChildCOVID-19Critical IllnessHospitalsHumansRespiration, ArtificialRetrospective StudiesRisk FactorsVenous ThromboembolismConceptsHospital-acquired venous thromboembolismInvasive mechanical ventilationRetrospective cohort studyVenous thromboembolismMechanical ventilationEndotracheal intubationCohort studyIll childrenRisk factorsGeneral pediatric intensive care unit populationPediatric intensive care unit populationConcurrent central venous cathetersIntensive care unit populationExtremity deep venous thrombosisPediatric intensive care unitHypercoagulability risk factorsDeep venous thrombosisCentral venous cathetersIntensive care unitEligible encountersIMV durationPulmonary embolismSecondary outcomesVenous cathetersPrimary outcome
2022
Mechanical Ventilation and Hospital-Acquired Venous Thromboembolism Among Critically Ill Children.
Sochet A, Havlicek E, Faustino E, Goldenberg N. Mechanical Ventilation and Hospital-Acquired Venous Thromboembolism Among Critically Ill Children. Hospital Pediatrics 2022, 12: 1099-1109. PMID: 36349533, DOI: 10.1542/hpeds.2022-006697.Peer-Reviewed Original ResearchMeSH KeywordsAnticoagulantsChildCohort StudiesCritical IllnessHospitalsHumansRespiration, ArtificialRetrospective StudiesRisk FactorsVenous ThromboembolismVenous ThrombosisConceptsHospital-acquired venous thromboembolismDeep venous thrombosisMechanical ventilationMultivariable logistic regressionIll childrenVenous thromboembolismCohort studyVenous thrombosisRegistry-based cohort studyExtremity deep venous thrombosisLogistic regressionHA-VTE eventsInvasive mechanical ventilationRetrospective cohort studyVTE risk factorsCentral venous catheterizationYears of ageHospital dischargePulmonary embolismPrimary outcomeVenous catheterizationRisk factorsClinical trialsProspective validationSystem registry
2021
Association of Race and Ethnicity with Sedation Management in Pediatric Intensive Care.
Natale J, Asaro L, Joseph J, Ulysse C, Ascenzi J, Bowens C, Wypij D, Curley M, Curley M, Wypij D, Allen G, Angus D, Asaro L, Ascenzi J, Bateman S, Borasino S, Bowens C, Bysani G, Cheifetz I, Cowl A, Dodson B, Faustino E, Fineman L, Flori H, Franck L, Gedeit R, Grant M, Harabin A, Haskins-Kiefer C, Hertzog J, Hutchins L, Kirby A, Lebet R, Matthay M, McLaughlin G, Natale J, Oren P, Polavarapu N, Schneider J, Schwarz A, Shanley T, Simone S, Singer L, Sorce L, Truemper E, Vander Heyden M, Watson R, Wells C. Association of Race and Ethnicity with Sedation Management in Pediatric Intensive Care. Annals Of The American Thoracic Society 2021, 18: 93-102. PMID: 32776853, PMCID: PMC7780975, DOI: 10.1513/annalsats.201912-872oc.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBlack PeopleChildChild, PreschoolCritical CareEthnicityFemaleHealthcare DisparitiesHispanic or LatinoHumansInfantInfant, NewbornIntensive Care Units, PediatricMaleMulticenter Studies as TopicPainPain ManagementRandomized Controlled Trials as TopicRespiration, ArtificialRespiratory InsufficiencyWhite PeopleConceptsSedation managementPain managementClinical trialsU.S. pediatric intensive care unitsPediatric intensive care unitCluster-randomized clinical trialRacial disparitiesIatrogenic withdrawal syndromeAcute respiratory failureEpisodes of painPlanned secondary analysisIntensive care unitPediatric intensive careAssociation of raceEthnicity groupsNon-Hispanic blacksPercentage of daysRespiratory failureUsual careCumulative dosingPediatric patientsWithdrawal syndromeBlack patientsCare unitIntervention arm
2020
Surfactant Protein D Is Associated With Severe Pediatric ARDS, Prolonged Ventilation, and Death in Children With Acute Respiratory Failure
Dahmer M, Flori H, Sapru A, Kohne J, Weeks H, Curley M, Matthay M, Quasney M, Network B, Bateman S, Berg M, Borasino S, Bysani G, Cowl A, Bowens C, Faustino E, Fineman L, Godshall A, Hirshberg E, Kirby A, McLaughlin G, Medar S, Oren P, Schneider J, Schwarz A, Shanley T, Sorce L, Truemper E, Vander Heyden M, Wittmayer K, Zuppa A, Wypij D. Surfactant Protein D Is Associated With Severe Pediatric ARDS, Prolonged Ventilation, and Death in Children With Acute Respiratory Failure. CHEST Journal 2020, 158: 1027-1035. PMID: 32275979, PMCID: PMC7478231, DOI: 10.1016/j.chest.2020.03.041.Peer-Reviewed Original ResearchConceptsAcute respiratory failureSP-D levelsPediatric ARDSRespiratory failureLung injurySurfactant protein DPlasma SPPrimary diagnosisPlasma SP-D levelsHigher oxygenation indexProtein DDays of intubationProspective cohort studyChronic lung diseaseRespiratory distress syndromeMulti-center studyYears of ageEnzyme-linked immunosorbentPediatric RiskPICU lengthOxygenation indexProlonged ventilationCohort studyMortality IIIDistress syndrome
2018
Sedation Management for Critically Ill Children with Pre-Existing Cognitive Impairment
Best K, Asaro L, Curley M, Investigators R, Wypij D, Allen G, Angus D, Ascenzi J, Bateman S, Borasino S, Bowens C, Bysani G, Cheifetz I, Cowl A, Dodson B, Faustino E, Fineman L, Flori H, Franck L, Gedeit R, Grant M, Harabin A, Haskins-Kiefer C, Hertzog J, Hutchins L, Kirby A, Lebet R, Matthay M, McLaughlin G, Natale J, Oren P, Polavarapu N, Schneider J, Schwarz A, Shanley T, Simone S, Singer L, Sorce L, Truemper E, Vander Heyden M, Watson R, Wells C. Sedation Management for Critically Ill Children with Pre-Existing Cognitive Impairment. The Journal Of Pediatrics 2018, 206: 204-211.e1. PMID: 30527750, PMCID: PMC6389364, DOI: 10.1016/j.jpeds.2018.10.042.Peer-Reviewed Original ResearchConceptsPediatric intensive care unitIntensive care unitCognitive impairmentSedation managementCare unitIll childrenStudy daysSevere pediatric acute respiratory distress syndromePediatric acute respiratory distress syndromePediatric Cerebral Performance CategoryAcute respiratory distress syndromePre-existing cognitive impairmentSedation management practicesAcute respiratory failureCerebral Performance CategoryEpisodes of painDevelopment of painRespiratory distress syndromeSedation assessment toolsIatrogenic withdrawal symptomsNeurotypical subjectsMore study daysAssessment toolSedative requirementsRespiratory failure