2023
Derivation, Validation, and Clinical Relevance of a Pediatric Sepsis Phenotype With Persistent Hypoxemia, Encephalopathy, and Shock*
Sanchez-Pinto L, Bennett T, Stroup E, Luo Y, Atreya M, Bubeck Wardenburg J, Chong G, Geva A, Faustino E, Farris R, Hall M, Rogerson C, Shah S, Weiss S, Khemani R. Derivation, Validation, and Clinical Relevance of a Pediatric Sepsis Phenotype With Persistent Hypoxemia, Encephalopathy, and Shock*. Pediatric Critical Care Medicine 2023, 24: 795-806. PMID: 37272946, PMCID: PMC10540758, DOI: 10.1097/pcc.0000000000003292.Peer-Reviewed Original ResearchMultiple organ dysfunction syndromeSepsis-associated multiple organ dysfunction syndromePersistent hypoxemiaAdjuvant therapySepsis phenotypesSevere pediatric acute respiratory distress syndromePediatric acute respiratory distress syndromeMulticenter observational cohort studyAcute respiratory distress syndromePropensity score-matched analysisCommon adjuvant therapyHeterogeneity of sepsisOrgan dysfunction syndromeObservational cohort studyRespiratory distress syndromeHospital mortalityCohort studyDysfunction syndromeSystemic inflammationDistress syndromeOrgan dysfunctionSeptic shockClinical syndromeCommon therapyClinical relevance
2020
Surfactant Protein D Is Associated With Severe Pediatric ARDS, Prolonged Ventilation, and Death in Children With Acute Respiratory Failure
Dahmer M, Flori H, Sapru A, Kohne J, Weeks H, Curley M, Matthay M, Quasney M, Network B, Bateman S, Berg M, Borasino S, Bysani G, Cowl A, Bowens C, Faustino E, Fineman L, Godshall A, Hirshberg E, Kirby A, McLaughlin G, Medar S, Oren P, Schneider J, Schwarz A, Shanley T, Sorce L, Truemper E, Vander Heyden M, Wittmayer K, Zuppa A, Wypij D. Surfactant Protein D Is Associated With Severe Pediatric ARDS, Prolonged Ventilation, and Death in Children With Acute Respiratory Failure. CHEST Journal 2020, 158: 1027-1035. PMID: 32275979, PMCID: PMC7478231, DOI: 10.1016/j.chest.2020.03.041.Peer-Reviewed Original ResearchConceptsAcute respiratory failureSP-D levelsPediatric ARDSRespiratory failureLung injurySurfactant protein DPlasma SPPrimary diagnosisPlasma SP-D levelsHigher oxygenation indexProtein DDays of intubationProspective cohort studyChronic lung diseaseRespiratory distress syndromeMulti-center studyYears of ageEnzyme-linked immunosorbentPediatric RiskPICU lengthOxygenation indexProlonged ventilationCohort studyMortality IIIDistress syndrome
2018
Sedation Management for Critically Ill Children with Pre-Existing Cognitive Impairment
Best K, Asaro L, Curley M, Investigators R, Wypij D, Allen G, Angus D, Ascenzi J, Bateman S, Borasino S, Bowens C, Bysani G, Cheifetz I, Cowl A, Dodson B, Faustino E, Fineman L, Flori H, Franck L, Gedeit R, Grant M, Harabin A, Haskins-Kiefer C, Hertzog J, Hutchins L, Kirby A, Lebet R, Matthay M, McLaughlin G, Natale J, Oren P, Polavarapu N, Schneider J, Schwarz A, Shanley T, Simone S, Singer L, Sorce L, Truemper E, Vander Heyden M, Watson R, Wells C. Sedation Management for Critically Ill Children with Pre-Existing Cognitive Impairment. The Journal Of Pediatrics 2018, 206: 204-211.e1. PMID: 30527750, PMCID: PMC6389364, DOI: 10.1016/j.jpeds.2018.10.042.Peer-Reviewed Original ResearchConceptsPediatric intensive care unitIntensive care unitCognitive impairmentSedation managementCare unitIll childrenStudy daysSevere pediatric acute respiratory distress syndromePediatric acute respiratory distress syndromePediatric Cerebral Performance CategoryAcute respiratory distress syndromePre-existing cognitive impairmentSedation management practicesAcute respiratory failureCerebral Performance CategoryEpisodes of painDevelopment of painRespiratory distress syndromeSedation assessment toolsIatrogenic withdrawal symptomsNeurotypical subjectsMore study daysAssessment toolSedative requirementsRespiratory failure