2023
Multicenter Study of a Risk Prediction Model for Critically Ill Children at High-Risk for Hospital-Acquired Venous Thromboembolism: Findings from the Children's Hospital-Acquired Thrombosis (CHAT) Consortium
Jaffray J, Mosha M, Branchford B, Amankwah E, Faustino E, Krava E, Stillings A, Young G, Goldenberg N. Multicenter Study of a Risk Prediction Model for Critically Ill Children at High-Risk for Hospital-Acquired Venous Thromboembolism: Findings from the Children's Hospital-Acquired Thrombosis (CHAT) Consortium. Blood 2023, 142: 809. DOI: 10.1182/blood-2023-187395.Peer-Reviewed Original ResearchHospital-acquired venous thromboembolismPediatric intensive care unitCongenital heart diseaseIll childrenMultivariable logistic regression modelAdmission/transferAutoimmune/inflammatory disordersCentral venous cathetersLength of hospitalizationCentral venous catheterizationDays post dischargeIntensive care unitUnivariate logistic regressionSubset of childrenP-valueLogistic regression modelsRisk assessment modelPICU admissionThromboprophylaxis measuresVenous thromboembolismChart reviewProspective cohortVenous cathetersCardiac surgeryMedian ageHospital-acquired venous thromboembolism during invasive mechanical ventilation in children: a single-center, retrospective cohort study
Havlicek E, Goldman Z, Faustino E, Ignjatovic V, Goldenberg N, Sochet A. Hospital-acquired venous thromboembolism during invasive mechanical ventilation in children: a single-center, retrospective cohort study. Journal Of Thrombosis And Haemostasis 2023, 21: 3145-3152. PMID: 37423387, DOI: 10.1016/j.jtha.2023.06.035.Peer-Reviewed Original ResearchConceptsHospital-acquired venous thromboembolismInvasive mechanical ventilationRetrospective cohort studyVenous thromboembolismMechanical ventilationEndotracheal intubationCohort studyIll childrenRisk factorsGeneral pediatric intensive care unit populationPediatric intensive care unit populationConcurrent central venous cathetersIntensive care unit populationExtremity deep venous thrombosisPediatric intensive care unitHypercoagulability risk factorsDeep venous thrombosisCentral venous cathetersIntensive care unitEligible encountersIMV durationPulmonary embolismSecondary outcomesVenous cathetersPrimary outcome
2021
Association of Race and Ethnicity with Sedation Management in Pediatric Intensive Care.
Natale J, Asaro L, Joseph J, Ulysse C, Ascenzi J, Bowens C, Wypij D, Curley M, Curley M, Wypij D, Allen G, Angus D, Asaro L, Ascenzi J, Bateman S, Borasino S, Bowens C, Bysani G, Cheifetz I, Cowl A, Dodson B, Faustino E, Fineman L, Flori H, Franck L, Gedeit R, Grant M, Harabin A, Haskins-Kiefer C, Hertzog J, Hutchins L, Kirby A, Lebet R, Matthay M, McLaughlin G, Natale J, Oren P, Polavarapu N, Schneider J, Schwarz A, Shanley T, Simone S, Singer L, Sorce L, Truemper E, Vander Heyden M, Watson R, Wells C. Association of Race and Ethnicity with Sedation Management in Pediatric Intensive Care. Annals Of The American Thoracic Society 2021, 18: 93-102. PMID: 32776853, PMCID: PMC7780975, DOI: 10.1513/annalsats.201912-872oc.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBlack PeopleChildChild, PreschoolCritical CareEthnicityFemaleHealthcare DisparitiesHispanic or LatinoHumansInfantInfant, NewbornIntensive Care Units, PediatricMaleMulticenter Studies as TopicPainPain ManagementRandomized Controlled Trials as TopicRespiration, ArtificialRespiratory InsufficiencyWhite PeopleConceptsSedation managementPain managementClinical trialsU.S. pediatric intensive care unitsPediatric intensive care unitCluster-randomized clinical trialRacial disparitiesIatrogenic withdrawal syndromeAcute respiratory failureEpisodes of painPlanned secondary analysisIntensive care unitPediatric intensive careAssociation of raceEthnicity groupsNon-Hispanic blacksPercentage of daysRespiratory failureUsual careCumulative dosingPediatric patientsWithdrawal syndromeBlack patientsCare unitIntervention arm
2018
Sedation Management for Critically Ill Children with Pre-Existing Cognitive Impairment
Best K, Asaro L, Curley M, Investigators R, Wypij D, Allen G, Angus D, Ascenzi J, Bateman S, Borasino S, Bowens C, Bysani G, Cheifetz I, Cowl A, Dodson B, Faustino E, Fineman L, Flori H, Franck L, Gedeit R, Grant M, Harabin A, Haskins-Kiefer C, Hertzog J, Hutchins L, Kirby A, Lebet R, Matthay M, McLaughlin G, Natale J, Oren P, Polavarapu N, Schneider J, Schwarz A, Shanley T, Simone S, Singer L, Sorce L, Truemper E, Vander Heyden M, Watson R, Wells C. Sedation Management for Critically Ill Children with Pre-Existing Cognitive Impairment. The Journal Of Pediatrics 2018, 206: 204-211.e1. PMID: 30527750, PMCID: PMC6389364, DOI: 10.1016/j.jpeds.2018.10.042.Peer-Reviewed Original ResearchConceptsPediatric intensive care unitIntensive care unitCognitive impairmentSedation managementCare unitIll childrenStudy daysSevere pediatric acute respiratory distress syndromePediatric acute respiratory distress syndromePediatric Cerebral Performance CategoryAcute respiratory distress syndromePre-existing cognitive impairmentSedation management practicesAcute respiratory failureCerebral Performance CategoryEpisodes of painDevelopment of painRespiratory distress syndromeSedation assessment toolsIatrogenic withdrawal symptomsNeurotypical subjectsMore study daysAssessment toolSedative requirementsRespiratory failure
2017
Tight Glycemic Control in Critically Ill Children
Agus M, Wypij D, Hirshberg E, Srinivasan V, Faustino E, Luckett P, Alexander J, Asaro L, Curley M, Steil G, Nadkarni V. Tight Glycemic Control in Critically Ill Children. New England Journal Of Medicine 2017, 376: 729-741. PMID: 28118549, PMCID: PMC5444653, DOI: 10.1056/nejmoa1612348.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBlood GlucoseCardiovascular Surgical ProceduresChildChild, PreschoolCritical IllnessFemaleGlucoseHospital MortalityHumansHyperglycemiaHypoglycemic AgentsInfantInfant, NewbornInsulinIntensive Care Units, PediatricIntention to Treat AnalysisLength of StayMalePostoperative PeriodConceptsHigher-target groupLower-target groupTight glycemic controlBlood glucose levelsGlycemic controlIll childrenGlucose levelsCardiac surgeryHealth care-associated infectionsICU-free daysVentilator-free daysCritically Ill ChildrenNormal blood glucose levelsIntensive care unitCare-associated infectionsSafety monitoring boardAverage glucose levelsHigh rateContinuous glucose monitoringIll adultsOrgan dysfunctionPrimary outcomeSevere hypoglycemiaTreat analysisCare unit
2014
Assessing the benefits and risks of tight glycemic control in critically ill children
Faustino E, Kandil S. Assessing the benefits and risks of tight glycemic control in critically ill children. Pediatric Health Medicine And Therapeutics 2014, Volume 5: 93-98. DOI: 10.2147/phmt.s50410.Peer-Reviewed Original ResearchTight glycemic controlIntensive care unitIll childrenGlycemic controlCare unitSurgical intensive care unitSubsequent multicenter trialSingle-center trialInsulin-induced hypoglycemiaIntravenous insulinCenter trialIll adultsIll patientsMulticenter trialTrialsHypoglycemiaChildrenHigh rateMortalityCurrent literatureInsulinRiskHyperglycemiaPatients