2024
Biomarker Assessment of a High-Risk, Data-Driven Pediatric Sepsis Phenotype Characterized by Persistent Hypoxemia, Encephalopathy, and Shock
Atreya M, Bennett T, Geva A, Faustino E, Rogerson C, Lutfi R, Cvijanovich N, Bigham M, Nowak J, Schwarz A, Baines T, Haileselassie B, Thomas N, Luo Y, Sanchez-Pinto L, Investigators F. Biomarker Assessment of a High-Risk, Data-Driven Pediatric Sepsis Phenotype Characterized by Persistent Hypoxemia, Encephalopathy, and Shock. Pediatric Critical Care Medicine 2024, 25: 512-517. PMID: 38465952, PMCID: PMC11153020, DOI: 10.1097/pcc.0000000000003499.Peer-Reviewed Original ResearchElectronic health recordsMultiple organ dysfunction syndromePediatric septic shock patientsSeptic shock patientsRisk strataElectronic health record dataSepsis phenotypesShock patientsPersistent multiple organ dysfunction syndromeAssociated with poor clinical outcomesDegree of systemic inflammationIncreased adjusted oddsHigh riskOrgan dysfunction syndromePoor clinical outcomesHealth recordsReceiver operating characteristic curveHigh-risk stratumArea under the receiver operating characteristic curveCritically ill patientsPredictive of deathSeverity of illnessAdjusted oddsIdentification of childrenOperating characteristics curve
2023
Inflammation Sub-Group Analysis in Pediatric HA-VTE Cases: A Report from the Children's Hospital Acquired Thrombosis Registry (CHAT) Registry
Harp T, Proctor K, Mosha M, Cox A, Jaffray J, Stillings A, Krava E, Amankwah E, Faustino E, Zakai N, Young G, Goldenberg N, Branchford B. Inflammation Sub-Group Analysis in Pediatric HA-VTE Cases: A Report from the Children's Hospital Acquired Thrombosis Registry (CHAT) Registry. Blood 2023, 142: 4015. DOI: 10.1182/blood-2023-190491.Peer-Reviewed Original ResearchPast medical historyInflammatory disease diagnosisHA-VTEDischarge diagnosisSystemic inflammationChronic inflammationAcute inflammationInflammatory diseasesOdds ratioCentral venous catheter placementAdmission/transferDays of dischargeLong-term morbidityVenous catheter placementOrgan system involvementPediatric patient populationType of inflammationClinical research effortsSub-group analysisUnderlying risk factorsInstitutional review boardElectronic health recordsChronic varietyHospital stayVenous thromboembolism