2024
Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm
Jiang Y, Luo C, Wang J, Palaniyappan L, Chang X, Xiang S, Zhang J, Duan M, Huang H, Gaser C, Nemoto K, Miura K, Hashimoto R, Westlye L, Richard G, Fernandez-Cabello S, Parker N, Andreassen O, Kircher T, Nenadić I, Stein F, Thomas-Odenthal F, Teutenberg L, Usemann P, Dannlowski U, Hahn T, Grotegerd D, Meinert S, Lencer R, Tang Y, Zhang T, Li C, Yue W, Zhang Y, Yu X, Zhou E, Lin C, Tsai S, Rodrigue A, Glahn D, Pearlson G, Blangero J, Karuk A, Pomarol-Clotet E, Salvador R, Fuentes-Claramonte P, Garcia-León M, Spalletta G, Piras F, Vecchio D, Banaj N, Cheng J, Liu Z, Yang J, Gonul A, Uslu O, Burhanoglu B, Uyar Demir A, Rootes-Murdy K, Calhoun V, Sim K, Green M, Quidé Y, Chung Y, Kim W, Sponheim S, Demro C, Ramsay I, Iasevoli F, de Bartolomeis A, Barone A, Ciccarelli M, Brunetti A, Cocozza S, Pontillo G, Tranfa M, Park M, Kirschner M, Georgiadis F, Kaiser S, Van Rheenen T, Rossell S, Hughes M, Woods W, Carruthers S, Sumner P, Ringin E, Spaniel F, Skoch A, Tomecek D, Homan P, Homan S, Omlor W, Cecere G, Nguyen D, Preda A, Thomopoulos S, Jahanshad N, Cui L, Yao D, Thompson P, Turner J, van Erp T, Cheng W, Feng J. Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm. Nature Communications 2024, 15: 5996. PMID: 39013848, PMCID: PMC11252381, DOI: 10.1038/s41467-024-50267-3.Peer-Reviewed Original ResearchConceptsGray matter changesDisorder constructsEnlarged striatumPsychiatric conditionsMental disordersSubcortical regionsSchizophreniaBiological foundationsMatter changesBrain imagingStriatumDisordersBiological factorsIndividualsSubtypesHealthy subjectsCross-sectional brain imagingHippocampusTemporal trajectoriesInternational cohortSubgroup 2Subgroup 1SubgroupsThe brain structure, inflammatory, and genetic mechanisms mediate the association between physical frailty and depression
Jiang R, Noble S, Rosenblatt M, Dai W, Ye J, Liu S, Qi S, Calhoun V, Sui J, Scheinost D. The brain structure, inflammatory, and genetic mechanisms mediate the association between physical frailty and depression. Nature Communications 2024, 15: 4411. PMID: 38782943, PMCID: PMC11116547, DOI: 10.1038/s41467-024-48827-8.Peer-Reviewed Original ResearchConceptsIncident depressionPre-frailPhysical frailtyFrail individualsPopulation attributable fraction analysisRisk factors of depressionMendelian randomization analysisFactors of depressionPotential causal effectModifiable risk factorsNon-frail individualsCross-sectional studyEffect of frailtyHigher disease burdenUK BiobankRandomization analysisBrain volumeDepression casesDisease burdenFrailtyRegional brain volumesIncreased riskDepressionHigh riskFollow-upReconfiguration of Structural and Functional Connectivity Coupling in Patient Subgroups With Adolescent Depression
Xu M, Li X, Teng T, Huang Y, Liu M, Long Y, Lv F, Zhi D, Li X, Feng A, Yu S, Calhoun V, Zhou X, Sui J. Reconfiguration of Structural and Functional Connectivity Coupling in Patient Subgroups With Adolescent Depression. JAMA Network Open 2024, 7: e241933. PMID: 38470418, PMCID: PMC10933730, DOI: 10.1001/jamanetworkopen.2024.1933.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdverse Childhood ExperiencesBrainCross-Sectional StudiesDepressionDepressive Disorder, MajorFemaleHumansConceptsAdolescent major depressive disorderMajor depressive disorderSC-FC couplingIncreased SC-FC couplingSC-FCMode networkSuicide attemptsFirst-episode major depressive disorderVisual networkMDD subgroupsNonsuicidal self-injurious behaviorRates of self-injuryHealthy controlsResting-state functional MRI dataMagnetic resonance imagingCross-sectional studySelf-injurious behaviorOutpatient psychiatry clinicFunctional MRI dataMajor life eventsFirst Affiliated Hospital of Chongqing Medical UniversityDepressive disorderNeurobiological mechanismsChildhood traumaSelf-injury
2023
Auditory oddball hypoactivation in schizophrenia
Nakahara S, Male A, Turner J, Calhoun V, Lim K, Mueller B, Bustillo J, O'Leary D, Voyvodic J, Belger A, Preda A, Mathalon D, Ford J, Guffanti G, Macciardi F, Potkin S, Van Erp T. Auditory oddball hypoactivation in schizophrenia. Psychiatry Research Neuroimaging 2023, 335: 111710. PMID: 37690161, DOI: 10.1016/j.pscychresns.2023.111710.Peer-Reviewed Original ResearchConceptsSchizophrenia polygenic risk scoresFunctional magnetic resonance imagingPolygenic risk scoresCognitive performanceOddball targetsAssociated with cognitive performanceRight supramarginal cortexCognitive domain performanceBrain imaging studiesAuditory oddball taskPrecuneus activationSchizophrenia individualsFrontal poleSchizophreniaOddball taskBrain activityRight thalamusHippocampal cortexRegional activityHypoactivationSample 2Sample 1PrecuneusHealthy volunteersCross-sectional data setsElevated C-reactive protein mediates the liver-brain axis: a preliminary study
Jiang R, Wu J, Rosenblatt M, Dai W, Rodriguez R, Sui J, Qi S, Liang Q, Xu B, Meng Q, Calhoun V, Scheinost D. Elevated C-reactive protein mediates the liver-brain axis: a preliminary study. EBioMedicine 2023, 93: 104679. PMID: 37356206, PMCID: PMC10320521, DOI: 10.1016/j.ebiom.2023.104679.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBrainC-Reactive ProteinCross-Sectional StudiesHumansInflammationLiver CirrhosisMagnetic Resonance ImagingMiddle AgedUnited StatesConceptsRegional gray matter volumeGray matter volumeCognitive functioningMost cognitive measuresUnderlying neurobiological factorsEffect sizeLarge effect sizesProspective memoryVisual memoryCognitive measuresExecutive functionTrail MakingCognitive performanceNeurobiological factorsSmall effect sizesProcessing speedVentral striatumParahippocampal gyrusCognitive declineCognitive impairmentMatter volumeMemoryFunctioningCross-sectional associationsLimited research