2024
A multimodal Neuroimaging-Based risk score for mild cognitive impairment
Zendehrouh E, Sendi M, Abrol A, Batta I, Hassanzadeh R, Calhoun V. A multimodal Neuroimaging-Based risk score for mild cognitive impairment. NeuroImage Clinical 2024, 45: 103719. PMID: 39637673, PMCID: PMC11664180, DOI: 10.1016/j.nicl.2024.103719.Peer-Reviewed Original ResearchMild cognitive impairment riskMild cognitive impairmentMild cognitive impairment groupRisk of mild cognitive impairmentRisk scoreUK Biobank participantsFunctional network connectivityCognitive impairmentPrecursor to ADSignificant cognitive declineBiobank participantsUK BiobankMild cognitive impairment individualsGenetic risk factorsAlzheimer's diseaseFunctional MRIHigh-risk groupStructural MRIAD riskRisk factorsCognitive declineFeatures of CNGray matterDifferentiate CNParticipantsThe brain structure, inflammatory, and genetic mechanisms mediate the association between physical frailty and depression
Jiang R, Noble S, Rosenblatt M, Dai W, Ye J, Liu S, Qi S, Calhoun V, Sui J, Scheinost D. The brain structure, inflammatory, and genetic mechanisms mediate the association between physical frailty and depression. Nature Communications 2024, 15: 4411. PMID: 38782943, PMCID: PMC11116547, DOI: 10.1038/s41467-024-48827-8.Peer-Reviewed Original ResearchConceptsIncident depressionPre-frailPhysical frailtyFrail individualsPopulation attributable fraction analysisRisk factors of depressionMendelian randomization analysisFactors of depressionPotential causal effectModifiable risk factorsNon-frail individualsCross-sectional studyEffect of frailtyHigher disease burdenUK BiobankRandomization analysisBrain volumeDepression casesDisease burdenFrailtyRegional brain volumesIncreased riskDepressionHigh riskFollow-up
2023
A brain‐wide risk score of Alzheimer’s disease based on multimodal neuroimaging predicts cognition in large N>37000 population data
Zendehrouh E, Sendi M, Calhoun V. A brain‐wide risk score of Alzheimer’s disease based on multimodal neuroimaging predicts cognition in large N>37000 population data. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.077591.Peer-Reviewed Original ResearchMild cognitive impairmentAD riskGenetic risk of ADCognitive scoresRisk of ADFunctional network connectivityUK BiobankAlzheimer's diseaseGenetic riskRisk scoreBackground Alzheimer’s diseaseFI scoreFluid intelligenceCognitive impairmentPopulation dataEvaluate individualsGray matterScoresRiskReaction timeBiotypesResting‐state dynamic functional network connectivity predicts cognition in 37,784 participants of UK Biobank
Sendi M, Zendehrouh E, Miller R, Salat D, Calhoun V. Resting‐state dynamic functional network connectivity predicts cognition in 37,784 participants of UK Biobank. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.065832.Peer-Reviewed Original ResearchFunctional network connectivityDynamic FNCDynamic functional network connectivityCognitive scoresFluid intelligenceCognitive declineAge-related cognitive declineGroup independent component analysisResting-state functional MRIBrain functional changesResting-state fMRIBrain functional network connectivityReaction timeParticipants of UK BiobankRT taskFunctional MRIRs-fMRIPairing taskCognitionIndependent component analysisUK BiobankBrainNetwork connectivityHealthy adultsData-driven componentsAssociations of physical frailty with health outcomes and brain structure in 483 033 middle-aged and older adults: a population-based study from the UK Biobank
Jiang R, Noble S, Sui J, Yoo K, Rosenblatt M, Horien C, Qi S, Liang Q, Sun H, Calhoun V, Scheinost D. Associations of physical frailty with health outcomes and brain structure in 483 033 middle-aged and older adults: a population-based study from the UK Biobank. The Lancet Digital Health 2023, 5: e350-e359. PMID: 37061351, PMCID: PMC10257912, DOI: 10.1016/s2589-7500(23)00043-2.Peer-Reviewed Original ResearchConceptsPopulation-based studyPhysical frailtyHealth-related outcomesBrain structuresMental healthHealth outcomesHealth measuresTotal white matter hyperintensitiesIndicators of frailtySeverity of frailtyLower gray matter volumePoor physical fitnessWhite matter hyperintensitiesGray matter volumeUK BiobankHealth-related measuresPoor mental healthMental health measuresDirection of associationMatter hyperintensitiesUnhealthy lifestyleEarly-life risksPsychiatric disordersNumerous confoundersPreventative strategies