2024
Adamts1 and Cyst Expansion in Polycystic Kidney Disease.
Kakade V, Akman Z, Motrapu M, Cassini M, Xu L, Moeckel G, Somlo S, Cantley L. Adamts1 and Cyst Expansion in Polycystic Kidney Disease. Journal Of The American Society Of Nephrology 2024 PMID: 39514301, DOI: 10.1681/asn.0000000557.Peer-Reviewed Original ResearchAutosomal dominant polycystic kidney diseasePolycystic kidney diseaseKidney diseaseLoss of Pkd1Cyst growthInterstitial macrophage accumulationDominant polycystic kidney diseaseInterstitial mononuclear cellsReduced cyst growthDetectable phenotypeMembrane remodelingMotif 1Progressive cyst growthIsoforms of versicanSimultaneous deletionPKD2 geneTubular basement membraneDisintegrin and metalloproteinaseRNA sequencingBasement membrane remodelingPKD1Thrombospondin motifs 1Cystic enlargementMacrophage accumulationCystic dilatationUsing Imaging Mass Cytometry to Define Cell Identities in AKI and CKD in Humans
Budiman T, Shelar A, Baker M, Weiss M, Cantley L, Kakade V. Using Imaging Mass Cytometry to Define Cell Identities in AKI and CKD in Humans. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024g4m5sdnf. DOI: 10.1681/asn.2024g4m5sdnf.Peer-Reviewed Original ResearchTubule-Specific Deletion of Adamts1 Slows Cyst Expansion in Polycystic Kidney Disease
Kakade V, Akman Z, Motrapu M, Cantley L. Tubule-Specific Deletion of Adamts1 Slows Cyst Expansion in Polycystic Kidney Disease. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.20246ecyxtfs. DOI: 10.1681/asn.20246ecyxtfs.Peer-Reviewed Original ResearchSegment-Specific Cyst Index (SSCI): A Quantitative Analysis of Segment-Specific Responses during Cystogenesis
Akman Z, Kakade V, Cantley L. Segment-Specific Cyst Index (SSCI): A Quantitative Analysis of Segment-Specific Responses during Cystogenesis. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024mpmapkd5. DOI: 10.1681/asn.2024mpmapkd5.Peer-Reviewed Original ResearchAnalysis of Kidney Biopsies from Patients with Glomerulonephritis Using Imaging Mass Cytometry Reveals Increase in Immune Cells with Associated Dedifferentiation and Injury of Tubular Cells
Weiss M, Kakade V, Baker M, Budiman T, Shelar A, Cantley L. Analysis of Kidney Biopsies from Patients with Glomerulonephritis Using Imaging Mass Cytometry Reveals Increase in Immune Cells with Associated Dedifferentiation and Injury of Tubular Cells. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.202490mzwbkc. DOI: 10.1681/asn.202490mzwbkc.Peer-Reviewed Original ResearchRationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis
Barsotti G, Luciano R, Kumar A, Meliambro K, Kakade V, Tokita J, Naik A, Fu J, Peck E, Pell J, Reghuvaran A, Tanvir E, Patel P, Zhang W, Li F, Moeckel G, Perincheri S, Cantley L, Moledina D, Wilson F, He J, Menon M. Rationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis. Kidney International Reports 2024, 9: 1354-1368. PMID: 38707807, PMCID: PMC11068976, DOI: 10.1016/j.ekir.2024.02.006.Peer-Reviewed Original ResearchMinimal change diseaseRandomized controlled trialsSafety of metforminDouble-blindPodocyte injuryAdjunctive therapyPlacebo-controlled randomized controlled trialsPhase III studyPhase II trialPrimary glomerular diseaseFocal segmental glomerulosclerosisEffect of metforminPhase IIPlacebo-controlledPreclinical dataNovel urineChange diseaseTissue markersRandomized trialsSegmental glomerulosclerosisGlomerular diseaseMechanistic biomarkersObservational studyFSGSInexpensive agent
2016
Cyclic‐AMP Regulates Glycogen Synthase Kinase‐3β by a Feed‐Forward Mechanism in Polycystic Kidney Disease
Kakade V, Tao S, Zhou X, Li X, Pandey P, Rajagopal M, Rao R. Cyclic‐AMP Regulates Glycogen Synthase Kinase‐3β by a Feed‐Forward Mechanism in Polycystic Kidney Disease. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.968.28.Peer-Reviewed Original ResearchCRE-binding proteinGlycogen synthase kinase-3βCAMP response elementSynthase kinase-3βSerine/threonine protein kinaseGSK3β expressionKinase-3βCAMP-responsive genesThreonine protein kinasePolycystic kidney diseaseCyst expansionCAMP levelsPotential binding sitesFeed-forward loopInhibition of GSK3βResponsive genesTranscription factorsProtein kinaseFeed-forward mechanismResponse elementGSK3β proteinCell survivalCREB activityGSK3βActive GSK3β