2024
Adamts1 and Cyst Expansion in Polycystic Kidney Disease.
Kakade V, Akman Z, Motrapu M, Cassini M, Xu L, Moeckel G, Somlo S, Cantley L. Adamts1 and Cyst Expansion in Polycystic Kidney Disease. Journal Of The American Society Of Nephrology 2024 PMID: 39514301, DOI: 10.1681/asn.0000000557.Peer-Reviewed Original ResearchAutosomal dominant polycystic kidney diseasePolycystic kidney diseaseKidney diseaseLoss of Pkd1Cyst growthInterstitial macrophage accumulationDominant polycystic kidney diseaseInterstitial mononuclear cellsReduced cyst growthDetectable phenotypeMembrane remodelingMotif 1Progressive cyst growthIsoforms of versicanSimultaneous deletionPKD2 geneTubular basement membraneDisintegrin and metalloproteinaseRNA sequencingBasement membrane remodelingPKD1Thrombospondin motifs 1Cystic enlargementMacrophage accumulationCystic dilatation
2016
Cyclic‐AMP Regulates Glycogen Synthase Kinase‐3β by a Feed‐Forward Mechanism in Polycystic Kidney Disease
Kakade V, Tao S, Zhou X, Li X, Pandey P, Rajagopal M, Rao R. Cyclic‐AMP Regulates Glycogen Synthase Kinase‐3β by a Feed‐Forward Mechanism in Polycystic Kidney Disease. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.968.28.Peer-Reviewed Original ResearchCRE-binding proteinGlycogen synthase kinase-3βCAMP response elementSynthase kinase-3βSerine/threonine protein kinaseGSK3β expressionKinase-3βCAMP-responsive genesThreonine protein kinasePolycystic kidney diseaseCyst expansionCAMP levelsPotential binding sitesFeed-forward loopInhibition of GSK3βResponsive genesTranscription factorsProtein kinaseFeed-forward mechanismResponse elementGSK3β proteinCell survivalCREB activityGSK3βActive GSK3β