2024
Patients with ulcerative colitis who have normalized histology are clinically stable after de-escalation of therapy
Akiyama S, St-Pierre J, Traboulsi C, Silfen A, Rai V, Rodriguez T, Erondu A, Steinberg J, Shaffer S, Christensen B, Rubin D. Patients with ulcerative colitis who have normalized histology are clinically stable after de-escalation of therapy. Npj Gut And Liver 2024, 1: 5. DOI: 10.1038/s44355-024-00005-9.Peer-Reviewed Original ResearchHistologic normalizationUlcerative colitisDe-escalationUC patientsDe-escalation of therapyTherapeutic de-escalationMedian follow-upDe-escalation groupProportion of patientsStudy assessed outcomesHistological recurrenceRecurrence rateSingle-centerClinical stabilityTherapeutic changeRemission outcomesFollow-upTherapyPatientsImmunomodulationAminosalicylatesWithdrawalColitisMonthsOutcomes
2020
Cumulative Histologic Inflammation Predicts Colorectal Neoplasia in Ulcerative Colitis: A Validation Study
Yvellez O, Rai V, Sossenheimer P, Hart J, Turner J, Weber C, Jurdi K, Rubin D. Cumulative Histologic Inflammation Predicts Colorectal Neoplasia in Ulcerative Colitis: A Validation Study. Inflammatory Bowel Diseases 2020, 27: 203-206. PMID: 32152624, PMCID: PMC7813748, DOI: 10.1093/ibd/izaa047.Peer-Reviewed Original ResearchConceptsCumulative inflammatory burdenDevelopment of CRNHistological inflammatory activityColorectal neoplasiaUC patientsUlcerative colitisCRN patientsHistologic inflammationSurveillance intervalsRisk of CRNLow-grade dysplasiaMaximum severitySt. Mark's HospitalCase-control cohortInflammatory burdenInflammatory indexDisease durationInflammatory activityChronic inflammationIndefinite dysplasiaColorectal cancerSurveillance episodesPatientsInflammationMean severity