2024
Endoscopic Normalization and Transition of J-Pouch Phenotypes Over Time in Patients With Inflammatory Bowel Disease
Akiyama S, Ollech J, Cohen N, Traboulsi C, Rai V, Glick L, Yi Y, Runde J, Cohen R, Olortegui K, Hurst R, Umanskiy K, Shogan B, Hyman N, Rubin M, Dalal S, Sakuraba A, Pekow J, Chang E, Rubin D. Endoscopic Normalization and Transition of J-Pouch Phenotypes Over Time in Patients With Inflammatory Bowel Disease. Inflammatory Bowel Diseases 2024, izae106. PMID: 38916136, DOI: 10.1093/ibd/izae106.Peer-Reviewed Original ResearchPouch-related fistulasInflammatory bowel diseaseNormal pouchDiffuse inflammationFocal inflammationAfferent limbBowel diseaseAssociated with favorable outcomesIleal pouch-anal anastomosisPouch-anal anastomosisPouch lossEndoscopic phenotypesIleostomy takedownFavorable outcomePouch inflammationPouch excisionPouch phenotypesPrimary phenotypeFistulaEndoscopic classificationInflammationPatientsPouch bodyCuffitisPhenotypic transition
2022
Histopathology of Colectomy Specimens Predicts Endoscopic Pouch Phenotype in Patients with Ulcerative Colitis
Akiyama S, Ollech J, Traboulsi C, Rai V, Glick L, Yi Y, Runde J, Olivas A, Weber C, Cohen R, Olortegui K, Hurst R, Umanskiy K, Shogan B, Rubin M, Dalal S, Sakuraba A, Pekow J, Chang E, Hart J, Hyman N, Rubin D. Histopathology of Colectomy Specimens Predicts Endoscopic Pouch Phenotype in Patients with Ulcerative Colitis. Digestive Diseases And Sciences 2022, 67: 4020-4031. PMID: 35288827, PMCID: PMC10966959, DOI: 10.1007/s10620-022-07405-y.Peer-Reviewed Original ResearchConceptsIleal pouch-anal anastomosisUlcerative colitisColectomy specimensTerminal ileal involvementCrohn's diseaseIleal involvementPouch fistulaFocal inflammationDeep inflammationLimb involvementPouch-anal anastomosisLogistic regression analysisIleostomy takedownPouch bodyPouch lossEndoscopic appearancePathology reviewMultivariable analysisHistologic featuresPoor prognosisPathological dataEndoscopic phenotypesHigh riskPatientsInflammation
2020
Cumulative Histologic Inflammation Predicts Colorectal Neoplasia in Ulcerative Colitis: A Validation Study
Yvellez O, Rai V, Sossenheimer P, Hart J, Turner J, Weber C, Jurdi K, Rubin D. Cumulative Histologic Inflammation Predicts Colorectal Neoplasia in Ulcerative Colitis: A Validation Study. Inflammatory Bowel Diseases 2020, 27: 203-206. PMID: 32152624, PMCID: PMC7813748, DOI: 10.1093/ibd/izaa047.Peer-Reviewed Original ResearchConceptsCumulative inflammatory burdenDevelopment of CRNHistological inflammatory activityColorectal neoplasiaUC patientsUlcerative colitisCRN patientsHistologic inflammationSurveillance intervalsRisk of CRNLow-grade dysplasiaMaximum severitySt. Mark's HospitalCase-control cohortInflammatory burdenInflammatory indexDisease durationInflammatory activityChronic inflammationIndefinite dysplasiaColorectal cancerSurveillance episodesPatientsInflammationMean severity
2019
Follow-Up of Patients With Ulcerative Colitis and Histological Normalization
Israel A, Christensen B, El Jurdi K, Rai V, Ollech J, Cohen R, Sakuraba A, Dalal S, Rubin D. Follow-Up of Patients With Ulcerative Colitis and Histological Normalization. Clinical Gastroenterology And Hepatology 2019, 18: 987-988.e1. PMID: 31228567, PMCID: PMC6923607, DOI: 10.1016/j.cgh.2019.06.025.Peer-Reviewed Original ResearchConceptsUlcerative colitisManagement of UCSpecific treatment goalsEndoscopic improvementHistological normalizationDisease activityMucosal injuryRemitting courseHistological endpointsTreatment goalsNatural historyColitisMicroscopic featuresUnanswered questionsInflammationPatientsChronicityMucosaInjuryHistologyDiagnosisEndpoint