2024
Endoscopic Normalization and Transition of J-Pouch Phenotypes Over Time in Patients With Inflammatory Bowel Disease
Akiyama S, Ollech J, Cohen N, Traboulsi C, Rai V, Glick L, Yi Y, Runde J, Cohen R, Olortegui K, Hurst R, Umanskiy K, Shogan B, Hyman N, Rubin M, Dalal S, Sakuraba A, Pekow J, Chang E, Rubin D. Endoscopic Normalization and Transition of J-Pouch Phenotypes Over Time in Patients With Inflammatory Bowel Disease. Inflammatory Bowel Diseases 2024, izae106. PMID: 38916136, DOI: 10.1093/ibd/izae106.Peer-Reviewed Original ResearchPouch-related fistulasInflammatory bowel diseaseNormal pouchDiffuse inflammationFocal inflammationAfferent limbBowel diseaseAssociated with favorable outcomesIleal pouch-anal anastomosisPouch-anal anastomosisPouch lossEndoscopic phenotypesIleostomy takedownFavorable outcomePouch inflammationPouch excisionPouch phenotypesPrimary phenotypeFistulaEndoscopic classificationInflammationPatientsPouch bodyCuffitisPhenotypic transition
2022
Histopathology of Colectomy Specimens Predicts Endoscopic Pouch Phenotype in Patients with Ulcerative Colitis
Akiyama S, Ollech J, Traboulsi C, Rai V, Glick L, Yi Y, Runde J, Olivas A, Weber C, Cohen R, Olortegui K, Hurst R, Umanskiy K, Shogan B, Rubin M, Dalal S, Sakuraba A, Pekow J, Chang E, Hart J, Hyman N, Rubin D. Histopathology of Colectomy Specimens Predicts Endoscopic Pouch Phenotype in Patients with Ulcerative Colitis. Digestive Diseases And Sciences 2022, 67: 4020-4031. PMID: 35288827, PMCID: PMC10966959, DOI: 10.1007/s10620-022-07405-y.Peer-Reviewed Original ResearchConceptsIleal pouch-anal anastomosisUlcerative colitisColectomy specimensTerminal ileal involvementCrohn's diseaseIleal involvementPouch fistulaFocal inflammationDeep inflammationLimb involvementPouch-anal anastomosisLogistic regression analysisIleostomy takedownPouch bodyPouch lossEndoscopic appearancePathology reviewMultivariable analysisHistologic featuresPoor prognosisPathological dataEndoscopic phenotypesHigh riskPatientsInflammationOutcomes of Ileoanal Pouch Anastomosis in Pediatric Ulcerative Colitis Are Worse in the Modern Era: A Time Trend Analysis Outcomes Following Ileal Pouch–Anal Anastomosis in Pediatric Ulcerative Colitis
Runde J, Erondu A, Akiyama S, Traboulsi C, Rai V, Glick L, Yi Y, Ollech J, Cohen R, Skowron K, Hurst R, Umanskiy K, Shogan B, Hyman N, Rubin M, Dalal S, Sakuraba A, Pekow J, Chang E, Rubin D. Outcomes of Ileoanal Pouch Anastomosis in Pediatric Ulcerative Colitis Are Worse in the Modern Era: A Time Trend Analysis Outcomes Following Ileal Pouch–Anal Anastomosis in Pediatric Ulcerative Colitis. Inflammatory Bowel Diseases 2022, 28: 1386-1394. PMID: 35040964, PMCID: PMC9434476, DOI: 10.1093/ibd/izab319.Peer-Reviewed Original ResearchConceptsIleal pouch-anal anastomosisPediatric ulcerative colitisPouch-anal anastomosisUlcerative colitisYears of agePouch survivalAdult patientsRetrospective single-center studyIleoanal pouch anastomosisAnti-TNF therapySingle-center studyKaplan-Meier curvesLog-rank testKaplan-Meier estimatesPediatric control subjectsElectronic medical recordsChi-square testPouch anastomosisPouch failureTotal proctocolectomyPediatric patientsSurgical outcomesControl subjectsMedical recordsRapid progression
2021
Endoscopic Phenotype of the J Pouch in Patients With Inflammatory Bowel Disease: A New Classification for Pouch Outcomes
Akiyama S, Ollech J, Rai V, Glick L, Yi Y, Traboulsi C, Runde J, Cohen R, Skowron K, Hurst R, Umanskiy K, Shogan B, Hyman N, Rubin M, Dalal S, Sakuraba A, Pekow J, Chang E, Rubin D. Endoscopic Phenotype of the J Pouch in Patients With Inflammatory Bowel Disease: A New Classification for Pouch Outcomes. Clinical Gastroenterology And Hepatology 2021, 20: 293-302.e9. PMID: 33549868, PMCID: PMC8339185, DOI: 10.1016/j.cgh.2021.02.010.Peer-Reviewed Original ResearchConceptsIleal pouch-anal anastomosisDiffuse inflammationPouch excisionSignificant contributing factorLimb involvementAnti-tumor necrosis factor drugsCox proportional hazards modelPouch-anal anastomosisFuture interventional studiesInflammatory bowel diseasePattern of inflammationHand-sewn anastomosisBody mass indexClostridioides difficile infectionLog-rank testContributing factorProportional hazards modelLogistic regression analysisEndoscopic patternsExtensive colitisIleostomy takedownPouch bodyPouch survivalBowel diseaseCommon complicationTHE CLINICAL FEATURES AND PROGNOSTIC VALUE OF INFLAMMATORY POLYPS IN THE J POUCH OF PATIENTS WITH INFLAMMATORY BOWEL DISEASE TREATED BY PROCTOCOLECTOMY WITH ILEAL POUCH-ANAL ANASTOMOSIS
Akiyama S, Ollech J, Rai V, Yi Y, Traboulsi C, Glick L, Runde J, Cohen R, Hurst R, Hyman N, Dalal S, Sakuraba A, Pekow J, Rubin D. THE CLINICAL FEATURES AND PROGNOSTIC VALUE OF INFLAMMATORY POLYPS IN THE J POUCH OF PATIENTS WITH INFLAMMATORY BOWEL DISEASE TREATED BY PROCTOCOLECTOMY WITH ILEAL POUCH-ANAL ANASTOMOSIS. Gastroenterology 2021, 160: s61-s62. DOI: 10.1053/j.gastro.2021.01.158.Peer-Reviewed Original ResearchTHE CLINICAL FEATURES AND PROGNOSTIC VALUE OF INFLAMMATORY POLYPS IN THE J POUCH OF PATIENTS WITH INFLAMMATORY BOWEL DISEASE TREATED BY PROCTOCOLECTOMY WITH ILEAL POUCH-ANAL ANASTOMOSIS
Akiyama S, Ollech J, Rai V, Yi Y, Traboulsi C, Glick L, Runde J, Cohen R, Hurst R, Hyman N, Dalal S, Sakuraba A, Pekow J, Rubin D. THE CLINICAL FEATURES AND PROGNOSTIC VALUE OF INFLAMMATORY POLYPS IN THE J POUCH OF PATIENTS WITH INFLAMMATORY BOWEL DISEASE TREATED BY PROCTOCOLECTOMY WITH ILEAL POUCH-ANAL ANASTOMOSIS. Inflammatory Bowel Diseases 2021, 27: s45-s45. DOI: 10.1093/ibd/izaa347.109.Peer-Reviewed Original ResearchIleal pouch-anal anastomosisInflammatory bowel diseaseAnti-TNF drugsInflammatory polypsPouch-anal anastomosisKaplan-Meier curvesJ-pouchIBD patientsPouch excisionEndoscopic findingsBowel diseaseRectal cuffDistal pouchRetrospective single-center studyCommon anatomical locationSingle-center studyLog-rank testErythema/edemaLogistic regression analysisDifferent anatomic areasRefractory colitisChronic pouchitisBackground PatientsTotal proctocolectomyIndependent predictors
2020
Pouchitis in inflammatory bowel disease: a review of diagnosis, prognosis, and treatment
Akiyama S, Rai V, Rubin D. Pouchitis in inflammatory bowel disease: a review of diagnosis, prognosis, and treatment. Intestinal Research 2020, 19: 1-11. PMID: 33138344, PMCID: PMC7873408, DOI: 10.5217/ir.2020.00047.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsIleal pouch-anal anastomosisInflammatory bowel diseaseBowel diseaseRisk factorsUlcerative colitis patientsPouch-anal anastomosisReview of diagnosisDysplasia/cancerNew biological agentsPouchitis developmentRefractory colitisColitis patientsPouch failureRestorative proctocolectomyPouch excisionCrohn's diseaseImpairs qualityTreatment optionsChronic conditionsPouchitisFrequent reasonPatientsDiseaseProctocolectomyPrognosis