2024
Patients with ulcerative colitis who have normalized histology are clinically stable after de-escalation of therapy
Akiyama S, St-Pierre J, Traboulsi C, Silfen A, Rai V, Rodriguez T, Erondu A, Steinberg J, Shaffer S, Christensen B, Rubin D. Patients with ulcerative colitis who have normalized histology are clinically stable after de-escalation of therapy. Npj Gut And Liver 2024, 1: 5. DOI: 10.1038/s44355-024-00005-9.Peer-Reviewed Original ResearchHistologic normalizationUlcerative colitisDe-escalationUC patientsDe-escalation of therapyTherapeutic de-escalationMedian follow-upDe-escalation groupProportion of patientsStudy assessed outcomesHistological recurrenceRecurrence rateSingle-centerClinical stabilityTherapeutic changeRemission outcomesFollow-upTherapyPatientsImmunomodulationAminosalicylatesWithdrawalColitisMonthsOutcomes
2021
Achieving Histologic Normalization in Ulcerative Colitis Is Associated With a Reduced Risk of Subsequent Dysplasia
Shaffer S, Erondu A, Traboulsi C, Rai V, Cleveland N, Israel A, Christensen B, Rubin D. Achieving Histologic Normalization in Ulcerative Colitis Is Associated With a Reduced Risk of Subsequent Dysplasia. Inflammatory Bowel Diseases 2021, 28: 553-559. PMID: 34037230, PMCID: PMC9122749, DOI: 10.1093/ibd/izab130.Peer-Reviewed Original ResearchConceptsPersistent histologic activityHistologic normalizationUlcerative colitisHistologic activityUC diagnosisSubsequent dysplasiaIncidence rateDysplasia developmentDiagnosis of UCCox regression analysisKaplan-Meier graphsImproved clinical outcomesDevelopment of dysplasiaHistologic inflammationUC durationDysplasia ratesDisease courseTertiary centerClinical outcomesDecreased riskPatient groupSurveillance intervalsHistologic assessmentRetrospective analysisReduced risk