Spectral Tuning of Ultraviolet Cone Pigments: An Interhelical Lock Mechanism
Sekharan S, Mooney V, Rivalta I, Kazmi M, Neitz M, Neitz J, Sakmar T, Yan E, Batista V. Spectral Tuning of Ultraviolet Cone Pigments: An Interhelical Lock Mechanism. Journal Of The American Chemical Society 2013, 135: 19064-19067. PMID: 24295328, PMCID: PMC4536979, DOI: 10.1021/ja409896y.Peer-Reviewed Original ResearchConceptsUV pigmentsCone pigmentsSpectral tuningActivation of rhodopsinAncestral pigmentMolecular evolutionVertebrate visionMutagenesis studiesPhotoreceptor rhodopsinMolecular levelStructural rearrangementsUnprotonated Schiff baseTransmembraneTM6PigmentsRhodopsinMutationsEssential componentRetinyl chromophoreHydrogen bonding networkMutantsTM2Structural modelPhysiologicalRearrangementSpectral Tuning in Halorhodopsin: The Chloride Pump Photoreceptor
Pal R, Sekharan S, Batista V. Spectral Tuning in Halorhodopsin: The Chloride Pump Photoreceptor. Journal Of The American Chemical Society 2013, 135: 9624-9627. PMID: 23777372, DOI: 10.1021/ja404600z.Peer-Reviewed Original ResearchConceptsKey amino acid residuesIon translocation pathwayAmino acid residuesSpectral tuningInternal water moleculesTranslocation pathwaySpecific hydrogen bondsHalobacterium salinarumAcid residuesMolecular levelStructural rearrangementsAnion transportCl depletionPhotoreceptorsInduces changesHalorhodopsinRetinyl chromophoreSalinarumMutationsResiduesPathwayFirst time