2021
Latent brain state dynamics and cognitive flexibility in older adults
Lee B, Cai W, Young CB, Yuan R, Ryman S, Kim J, Santini V, Henderson VW, Poston KL, Menon V. Latent brain state dynamics and cognitive flexibility in older adults. Progress In Neurobiology 2021, 208: 102180. PMID: 34627994, PMCID: PMC9585912, DOI: 10.1016/j.pneurobio.2021.102180.Peer-Reviewed Original ResearchConceptsBrain flexibilityOlder adultsBrain statesWhole-brain fMRI dataBrain state dynamicsHealthy older adultsCognitive flexibilityMemory taskCognitive inflexibilityNeurocomputational frameworkCognitive deficitsFMRI dataCognitive impairmentDynamic temporal propertiesInflexibilityAdultsTemporal propertiesPublic health concernCognitionSternbergElderly populationHealth concernTaskDeficitsImpairment
2019
Three-year follow-up of prospective trial of focused ultrasound thalamotomy for essential tremor.
Halpern CH, Santini V, Lipsman N, Lozano AM, Schwartz ML, Shah BB, Elias WJ, Cosgrove GR, Hayes MT, McDannold N, Aldrich C, Eisenberg HM, Gandhi D, Taira T, Gwinn R, Ro S, Witt J, Jung NY, Chang JW, Rosenberg J, Ghanouni P. Three-year follow-up of prospective trial of focused ultrasound thalamotomy for essential tremor. Neurology 2019, 93: e2284-e2293. PMID: 31748250, DOI: 10.1212/wnl.0000000000008561.Peer-Reviewed Original ResearchConceptsFocused ultrasound thalamotomyAdverse eventsQuality of lifeEssential tremorProspective trialUltrasound thalamotomyMedication-refractory essential tremorTcMRgFUS thalamotomyMulticenter prospective trialNew adverse eventsClass IV evidenceHand tremorEssential Tremor QuestionnaireSevere essential tremorClinical rating scalesMagnetic resonance-guided focused ultrasound thalamotomyClinical outcomesFunctional disabilityThird followTreatment metricsTremor scorePostural tremorDurable benefitThalamotomyMedian score
2018
Slower saccadic reading in Parkinson’s disease
Jehangir N, Yu CY, Song J, Shariati MA, Binder S, Beyer J, Santini V, Poston K, Liao YJ. Slower saccadic reading in Parkinson’s disease. PLOS ONE 2018, 13: e0191005. PMID: 29364897, PMCID: PMC5783375, DOI: 10.1371/journal.pone.0191005.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCase-Control StudiesFemaleHumansMaleMiddle AgedParkinson DiseaseReadingSaccadesYoung AdultConceptsUnified Parkinson's Disease Rating ScaleDuration of diseasePD patientsDisease Rating ScaleParkinson's diseaseQuality of lifeConvergence insufficiencyVisual Functioning Questionnaire-25Parkinson's Disease Rating ScaleDegeneration of dopaminergicVFQ-25 scoresMontreal Cognitive Assessment (MoCA) testAbnormal eye movementsNon-motor deficitsIdiopathic Parkinson's diseaseNational Eye InstituteAge-matched controlsKing-Devick testCognitive Assessment testEye InstituteMoCA scoresPatientsControl groupClinical settingMotor difficulties
2017
Transcranial MRI‐guided high‐intensity focused ultrasound for treatment of essential tremor: A pilot study on the correlation between lesion size, lesion location, thermal dose, and clinical outcome
Federau C, Goubran M, Rosenberg J, Henderson J, Halpern CH, Santini V, Wintermark M, Pauly K, Ghanouni P. Transcranial MRI‐guided high‐intensity focused ultrasound for treatment of essential tremor: A pilot study on the correlation between lesion size, lesion location, thermal dose, and clinical outcome. Journal Of Magnetic Resonance Imaging 2017, 48: 58-65. PMID: 29076274, DOI: 10.1002/jmri.25878.Peer-Reviewed Original ResearchConceptsMedication-refractory essential tremorClinical outcomesEssential tremorThalamic nucleiLesion volumeLesion sizeAnterior commissure-posterior commissure planeLateral posterior thalamic nucleusPilot studyFinal lesion volumePosterior thalamic nucleusPromising noninvasive methodWilcoxon twoVentral divisionPosttreatment imagesLesion locationYear posttreatmentPosterior commissureScore improvementDoseNoninvasive methodTremorJ. MagnStatistical significanceTechnical efficacyCost‐effectiveness of focused ultrasound, radiosurgery, and DBS for essential tremor
Ravikumar VK, Parker JJ, Hornbeck TS, Santini VE, Pauly KB, Wintermark M, Ghanouni P, Stein SC, Halpern CH. Cost‐effectiveness of focused ultrasound, radiosurgery, and DBS for essential tremor. Movement Disorders 2017, 32: 1165-1173. PMID: 28370272, DOI: 10.1002/mds.26997.Peer-Reviewed Original Research
2009
Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy After Repetitive Head Injury
McKee AC, Cantu RC, Nowinski CJ, Hedley-Whyte ET, Gavett BE, Budson AE, Santini VE, Lee HS, Kubilus CA, Stern RA. Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy After Repetitive Head Injury. Journal Of Neuropathology & Experimental Neurology 2009, 68: 709-735. PMID: 19535999, PMCID: PMC2945234, DOI: 10.1097/nen.0b013e3181a9d503.Peer-Reviewed Original ResearchConceptsChronic traumatic encephalopathyTraumatic encephalopathyProgressive tauopathyTau-immunoreactive neurofibrillary tanglesRepetitive brain traumaRepetitive head injuryProgressive neurological deteriorationCavum septum pellucidumSuperficial cortical layersMedial temporal lobeAstrocytic tanglesTau-immunoreactiveNeurological deteriorationDementia pugilisticaVentricular dilatationBrain traumaHead injurySeptum pellucidumNeurofibrillary degenerationMammillary bodiesNeurofibrillary tanglesDiffuse plaquesGait abnormalitiesMemory disturbanceTemporal lobe
2008
Clock drawing performance in cognitively normal elderly
Hubbard EJ, Santini V, Blankevoort CG, Volkers KM, Barrup MS, Byerly L, Chaisson C, Jefferson AL, Kaplan E, Green RC, Stern RA. Clock drawing performance in cognitively normal elderly. Archives Of Clinical Neuropsychology 2008, 23: 295-327. PMID: 18243644, PMCID: PMC2752157, DOI: 10.1016/j.acn.2007.12.003.Peer-Reviewed Original Research