2022
Magnetic resonance imaging–guided focused ultrasound thalamotomy for essential tremor: 5-year follow-up results
Cosgrove GR, Lipsman N, Lozano AM, Chang JW, Halpern C, Ghanouni P, Eisenberg H, Fishman P, Taira T, Schwartz ML, McDannold N, Hayes M, Ro S, Shah B, Gwinn R, Santini VE, Hynynen K, Elias WJ. Magnetic resonance imaging–guided focused ultrasound thalamotomy for essential tremor: 5-year follow-up results. Journal Of Neurosurgery 2022, 138: 2022.6.jns212483. PMID: 35932269, PMCID: PMC10193464, DOI: 10.3171/2022.6.jns212483.Peer-Reviewed Original ResearchConceptsFunctional disability scoreAdverse eventsFocused ultrasound thalamotomyQuality of lifeDisability scoresMotor scoresUltrasound thalamotomyMagnetic resonance imaging-guided focused ultrasound thalamotomyEssential tremorMedication-refractory essential tremorNew adverse eventsCohort of patientsQUEST scoresMulticenter clinical trialClinical trial registrationEssential Tremor QuestionnaireLong-term safetyClinical rating scalesRespective time pointsTremor improvementTRIAL REGISTRATIONClinical trialsTremor scorePostural tremorLife measures
2020
Case Report on Deep Brain Stimulation Rescue After Suboptimal MR-Guided Focused Ultrasound Thalamotomy for Essential Tremor: A Tractography-Based Investigation
Saluja S, Barbosa DAN, Parker JJ, Huang Y, Jensen MR, Ngo V, Santini VE, Pauly KB, Ghanouni P, McNab JA, Halpern CH. Case Report on Deep Brain Stimulation Rescue After Suboptimal MR-Guided Focused Ultrasound Thalamotomy for Essential Tremor: A Tractography-Based Investigation. Frontiers In Human Neuroscience 2020, 14: 191. PMID: 32676015, PMCID: PMC7333679, DOI: 10.3389/fnhum.2020.00191.Peer-Reviewed Original ResearchRefractory essential tremorVentralis intermedius nucleusEssential tremorLong-term outcome dataMRgFUS lesionsFocused ultrasound thalamotomyPrevalent movement disorderIntermedius nucleusSurgical interventionCase reportMovement disordersNeuromodulatory proceduresUltrasound thalamotomyTremor recurrenceTremor reliefInitial improvementBilateral DBSInvasive proceduresOutcome dataTremor controlLesionsMRgFUSDiffusion MRI tractographyMonopolar stimulationHand tremor
2019
Three-year follow-up of prospective trial of focused ultrasound thalamotomy for essential tremor.
Halpern CH, Santini V, Lipsman N, Lozano AM, Schwartz ML, Shah BB, Elias WJ, Cosgrove GR, Hayes MT, McDannold N, Aldrich C, Eisenberg HM, Gandhi D, Taira T, Gwinn R, Ro S, Witt J, Jung NY, Chang JW, Rosenberg J, Ghanouni P. Three-year follow-up of prospective trial of focused ultrasound thalamotomy for essential tremor. Neurology 2019, 93: e2284-e2293. PMID: 31748250, DOI: 10.1212/wnl.0000000000008561.Peer-Reviewed Original ResearchConceptsFocused ultrasound thalamotomyAdverse eventsQuality of lifeEssential tremorProspective trialUltrasound thalamotomyMedication-refractory essential tremorTcMRgFUS thalamotomyMulticenter prospective trialNew adverse eventsClass IV evidenceHand tremorEssential Tremor QuestionnaireSevere essential tremorClinical rating scalesMagnetic resonance-guided focused ultrasound thalamotomyClinical outcomesFunctional disabilityThird followTreatment metricsTremor scorePostural tremorDurable benefitThalamotomyMedian score
2017
Transcranial MRI‐guided high‐intensity focused ultrasound for treatment of essential tremor: A pilot study on the correlation between lesion size, lesion location, thermal dose, and clinical outcome
Federau C, Goubran M, Rosenberg J, Henderson J, Halpern CH, Santini V, Wintermark M, Pauly K, Ghanouni P. Transcranial MRI‐guided high‐intensity focused ultrasound for treatment of essential tremor: A pilot study on the correlation between lesion size, lesion location, thermal dose, and clinical outcome. Journal Of Magnetic Resonance Imaging 2017, 48: 58-65. PMID: 29076274, DOI: 10.1002/jmri.25878.Peer-Reviewed Original ResearchConceptsMedication-refractory essential tremorClinical outcomesEssential tremorThalamic nucleiLesion volumeLesion sizeAnterior commissure-posterior commissure planeLateral posterior thalamic nucleusPilot studyFinal lesion volumePosterior thalamic nucleusPromising noninvasive methodWilcoxon twoVentral divisionPosttreatment imagesLesion locationYear posttreatmentPosterior commissureScore improvementDoseNoninvasive methodTremorJ. MagnStatistical significanceTechnical efficacy