2022
Magnetic resonance imaging–guided focused ultrasound thalamotomy for essential tremor: 5-year follow-up results
Cosgrove GR, Lipsman N, Lozano AM, Chang JW, Halpern C, Ghanouni P, Eisenberg H, Fishman P, Taira T, Schwartz ML, McDannold N, Hayes M, Ro S, Shah B, Gwinn R, Santini VE, Hynynen K, Elias WJ. Magnetic resonance imaging–guided focused ultrasound thalamotomy for essential tremor: 5-year follow-up results. Journal Of Neurosurgery 2022, 138: 2022.6.jns212483. PMID: 35932269, PMCID: PMC10193464, DOI: 10.3171/2022.6.jns212483.Peer-Reviewed Original ResearchConceptsFunctional disability scoreAdverse eventsFocused ultrasound thalamotomyQuality of lifeDisability scoresMotor scoresUltrasound thalamotomyMagnetic resonance imaging-guided focused ultrasound thalamotomyEssential tremorMedication-refractory essential tremorNew adverse eventsCohort of patientsQUEST scoresMulticenter clinical trialClinical trial registrationEssential Tremor QuestionnaireLong-term safetyClinical rating scalesRespective time pointsTremor improvementTRIAL REGISTRATIONClinical trialsTremor scorePostural tremorLife measures
2021
Neurology trial registrations on ClinicalTrials.gov between 2007 and 2018: A cross-sectional analysis of characteristics, early discontinuation, and results reporting
Turner BE, Magnani CJ, Frolov A, Weeks BT, Steinberg JR, Huda N, Shah LM, Zuroff L, Gu BJ, Rasmussen H, Edwards JG, Save AV, Shen M, Ren M, Bryant BR, Ma Q, Feng AY, Liang AC, Santini VE. Neurology trial registrations on ClinicalTrials.gov between 2007 and 2018: A cross-sectional analysis of characteristics, early discontinuation, and results reporting. Journal Of The Neurological Sciences 2021, 428: 117579. PMID: 34332371, DOI: 10.1016/j.jns.2021.117579.Peer-Reviewed Original ResearchConceptsEarly discontinuationClinical trialsTrial characteristicsNeurological disease burdenMultivariable logistic regressionCross-sectional analysisGovernment-funded trialsYear of completionMultivariable analysisCox regressionTreatment optionsDisease burdenHigher oddsTrial completionClinical careDiscontinuationLower riskAcademic trialsNeurology clinical trialsGreater riskLogistic regressionComparison trialEvidence baseTrialsTherapeutic focus