2021
The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation
Carley E, Stewart R, Zieman AG, Jalilian I, King DE, Zubek AE, Lin S, Horsley V, King MC. The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation. ELife 2021, 10: e58541. PMID: 33779546, PMCID: PMC8051949, DOI: 10.7554/elife.58541.Peer-Reviewed Original ResearchConceptsCell fateEpidermal cell fateLinker of nucleoskeletonCell fate decisionsEpidermal differentiation genesEpidermal differentiationDirect force transmissionEpidermal stem cellsCytoskeleton (LINC) complexLINC complexFate decisionsNuclear laminaType laminsDifferentiation genesIntegrin engagementForce transductionDifferentiation concomitantChemical signalsMechanotransduction pathwaysKeratinocyte progenitorsMolecular biosensorsStem cellsKeratinocyte differentiationDifferentiationMechanical input
2012
Development and homeostasis of the sebaceous gland
Niemann C, Horsley V. Development and homeostasis of the sebaceous gland. Seminars In Cell And Developmental Biology 2012, 23: 928-936. PMID: 22960253, PMCID: PMC5595243, DOI: 10.1016/j.semcdb.2012.08.010.Peer-Reviewed Original ResearchConceptsDistinct signaling pathwaysSebaceous gland biologyLipid composition resultsLineage differentiationSignaling pathwaysGland developmentNormal developmentSkin homeostasisMammalian skinEpidermal appendagesTumor formationCell linesCurrent knowledgeDifferentiationCrucial mediatorLipid metabolismAtrophic sebaceous glandsNew insightsVivo mechanismsHomeostasisSebaceous glandsAbnormal proliferationSebaceous gland developmentProliferationImportant role