2005
Mild Hypothermia Impairs Left Ventricular Diastolic but Not Systolic Function
Fischer U, Cox C, Laine G, Mehlhorn U, Allen S. Mild Hypothermia Impairs Left Ventricular Diastolic but Not Systolic Function. Journal Of Investigative Surgery 2005, 18: 291-296. PMID: 16319049, DOI: 10.1080/08941930500327047.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody TemperatureCardiac OutputCardiopulmonary BypassDiastoleDogsFemaleHemodynamicsHypothermia, InducedMaleSystoleVentricular Function, LeftConceptsPreload recruitable stroke workSystolic functionCardiopulmonary bypassCardiac outputCardioplegic arrestBody temperatureEarly post-CPB periodPost-CPB periodImpact of hypothermiaLeft ventricular functionRecruitable stroke workDP/Ventricular diastolicDiastolic functionCardiac dysfunctionVentricular functionLV diastolicHYPO groupCPB periodMyocardial protectionAnesthetized dogsMild hypothermiaStroke workLV micromanometerBaseline levels
2003
Regional hypothermia reduces mucosal NF-κB and PMN priming via gut lymph during canine mesenteric Ischemia/Reperfusion1,2 1This paper was presented at the annual meeting of the Association for Academic Surgery, November 7–9, 2002, Boston, MA. 2Supported in part by NIGMS grants P50 GM38529-01, KO8 GM000675, and T32 GM08792.
Hassoun H, Fischer U, Attuwaybi B, Moore F, Safi H, Allen S, Cox C. Regional hypothermia reduces mucosal NF-κB and PMN priming via gut lymph during canine mesenteric Ischemia/Reperfusion1,2 1This paper was presented at the annual meeting of the Association for Academic Surgery, November 7–9, 2002, Boston, MA. 2Supported in part by NIGMS grants P50 GM38529-01, KO8 GM000675, and T32 GM08792. Journal Of Surgical Research 2003, 115: 121-126. PMID: 14572782, DOI: 10.1016/s0022-4804(03)00298-1.Peer-Reviewed Original ResearchConceptsTransvascular protein clearancePMN superoxide productionGut lymphIntraischemic hypothermiaNF-kappaB DNAProtein clearancePMN primingFistula modelRegional hypothermiaMesenteric ischemia/reperfusionSuperoxide productionPolymorphonuclear neutrophil (PMN) primingRemote organ injuryPro-inflammatory mediatorsMin of reperfusionEnd of ischemiaIschemia/reperfusionNF-kappaB activationNF-kappaB activityMesenteric ischemiaNeutrophil primingH reperfusionOrgan injuryReperfusion injuryMin reperfusion