2015
En Bloc Resection of Pancoast Tumor with Adjuvant Aortic Endograft and Chemoradiation
Lu T, Fischer U, Marco R, Naoum J, Reardon M, Lumsden A, Blackmon S, Davies M. En Bloc Resection of Pancoast Tumor with Adjuvant Aortic Endograft and Chemoradiation. Methodist DeBakey Cardiovascular Journal 2015, 11: 140-4. PMID: 26306134, PMCID: PMC4547671, DOI: 10.14797/mdcj-11-2-140.Peer-Reviewed Original ResearchMeSH KeywordsAorta, ThoracicBlood Vessel ProsthesisBlood Vessel Prosthesis ImplantationCarcinoma, Non-Small-Cell LungChemoradiotherapy, AdjuvantEndovascular ProceduresFemaleHumansLung NeoplasmsMagnetic Resonance ImagingMiddle AgedNeoplasm StagingPancoast SyndromePneumonectomyPolyethylene TerephthalatesProsthesis DesignTreatment OutcomeConceptsBloc resectionAortic endograftsGore TAG thoracic endograftCarotid-subclavian bypassOpen operative managementSensitive anatomic locationEn bloc resectionAdjuvant chemoradiationAortic invasionAortic involvementAortic resectionChemoradiation regimensSubsequent chemoradiationAdjuvant therapyAortic injuryPancoast tumorStage IIIABony invasionSelect patientsAortic ruptureCardiopulmonary bypassSubclavian arteryComplex resectionsUpper lobeHigh morbidity
2014
Dissection of left iliac artery during anterior lumbar interspace fusion: Report of a case
Fischer U, Davies M, Sayed H. Dissection of left iliac artery during anterior lumbar interspace fusion: Report of a case. Vascular 2014, 23: 176-178. PMID: 24848500, DOI: 10.1177/1708538114534235.Peer-Reviewed Original ResearchConceptsVascular injuryCommon iliac artery dissectionEarly post-operative periodAnterior lumbar interbody fusionAcute limb ischemiaIliac artery dissectionAdequate surgical exposurePost-operative periodLumbar interbody fusionArtery dissectionLimb ischemiaUncommon complicationIliac arterySurgical exposureInterbody fusionVenous lacerationSpine surgeryGreat vesselsLumbar interbodyInjuryCommon typeDisc spaceDissectionVesselsComplicationsIleal Perforation in a Young Female with Churg-Strauss Syndrome
Ikoma N, Fischer U, Covinsky M, Quesada A, Gomez R, Mccray C, Warner N, Ko T. Ileal Perforation in a Young Female with Churg-Strauss Syndrome. The American Surgeon 2014, 80: 94-96. PMID: 24401524, DOI: 10.1177/000313481408000133.Peer-Reviewed Original Research
2013
Bouveret Syndrome
Shah S, Walker P, Fischer U, Karanjawala B, Khan S. Bouveret Syndrome. Journal Of Gastrointestinal Surgery 2013, 17: 1720-1721. PMID: 23775095, DOI: 10.1007/s11605-013-2244-z.Peer-Reviewed Original ResearchConceptsBouveret's syndromeGastric outlet obstructionMultiple medical comorbiditiesPost-operative courseUnremarkable post-operative courseAbdominal painMedical comorbiditiesCholecystoduodenal fistulaGallstone ileusOperative explorationOutlet obstructionSurgical managementElderly womenRare disorderComorbiditiesGallstonesRare variantsSyndromeTypical ageWomenIleusNauseaFistulaPainPatients
2012
Gallstone Ileus Ten Days after Laparoscopic Cholecystectomy
Martin L, Fischer U, Robinson E, Ko T. Gallstone Ileus Ten Days after Laparoscopic Cholecystectomy. The American Surgeon 2012, 78: 292-294. PMID: 22546112, DOI: 10.1177/000313481207800521.Peer-Reviewed Original ResearchGallstone ileus ten days after laparoscopic cholecystectomy.
Martin L, Fischer U, Robinson E, Ko T. Gallstone ileus ten days after laparoscopic cholecystectomy. The American Surgeon 2012, 78: e292-4. PMID: 22691335.Peer-Reviewed Original ResearchAcute DiseaseCholecystectomy, LaparoscopicCholelithiasisFemaleFollow-Up StudiesGallstonesHumansIleal DiseasesIleusLaparotomyMiddle AgedMinimally Invasive Surgical ProceduresPostoperative ComplicationsReoperationRisk AssessmentSeverity of Illness IndexTime FactorsTomography, X-Ray ComputedTreatment OutcomeUnretrieved Gallstone Mimicking an Intra-abdominal Soft Tissue Mass
Hall J, Fischer U, Wray C. Unretrieved Gallstone Mimicking an Intra-abdominal Soft Tissue Mass. The American Surgeon 2012, 78: 59-61. PMID: 22369794, DOI: 10.1177/000313481207800203.Peer-Reviewed Original Research
2010
A Novel Physiologic Model for the Study of Abdominal Compartment Syndrome (ACS)
Shah S, Jimenez F, Walker P, Xue H, Uray K, Aroom K, Fischer U, Laine G, Stewart R, Norbury K, Cox C. A Novel Physiologic Model for the Study of Abdominal Compartment Syndrome (ACS). Journal Of Trauma And Acute Care Surgery 2010, 68: 682-689. PMID: 20220423, DOI: 10.1097/ta.0b013e3181c453cb.Peer-Reviewed Original ResearchConceptsAbdominal compartment syndromeMean arterial pressureHemorrhagic shock/resuscitationShock/resuscitationUrine outputInspiratory pressureAbdominal pressureDevelopment of ACSMesenteric venous hypertensionPulmonary artery pressureCentral venous pressureDamage control surgeryPeak inspiratory pressureLarge animal modelArtery pressureVenous hypertensionArterial pressureCompartment syndromeVenous pressureControl surgeryHemodynamic measurementsHemorrhagic shockAbdominal packingIntraperitoneal instillationBase excess
2009
Regulation of Endothelial Nitric Oxide Synthase (eNOS) in Myocardium Subjected to Cardioplegic Arrest
Fischer U, Klass O, Cox C, Stock U, Antonyan A, Brixius K, Fischer J, Mehlhorn U, Bloch W. Regulation of Endothelial Nitric Oxide Synthase (eNOS) in Myocardium Subjected to Cardioplegic Arrest. The Thoracic And Cardiovascular Surgeon 2009, 57: 379-385. PMID: 19795322, DOI: 10.1055/s-0029-1185873.Peer-Reviewed Original ResearchAnimalsCardiopulmonary BypassEnzyme ActivationFemaleHeart Arrest, InducedHeart VentriclesImmunohistochemistryMaleMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Models, AnimalMyocardial ContractionMyocardiumNitric Oxide Synthase Type IIIPhosphorylationProto-Oncogene Proteins c-aktSerineSwineThreonineTime FactorsVentricular Function, Left
2008
Mechanics of the left ventricular myocardial interstitium: effects of acute and chronic myocardial edema
Desai K, Laine G, Stewart R, Cox C, Quick C, Allen S, Fischer U. Mechanics of the left ventricular myocardial interstitium: effects of acute and chronic myocardial edema. AJP Heart And Circulatory Physiology 2008, 294: h2428-h2434. PMID: 18375722, DOI: 10.1152/ajpheart.00860.2007.Peer-Reviewed Original ResearchConceptsLeft ventricular chamber complianceMyocardial interstitial edemaChronic myocardial edemaInterstitial edemaMyocardial edemaMyocardial interstitiumChamber complianceCardiac functionCoronary sinus pressure elevationVentricular chamberDiastolic cardiac functionPulmonary artery bandingLeft ventricular chamberAcute myocardial edemaPressure-volume relationshipEdema formsEdematous heartInterstitial fibrosisPressure elevationAcute edemaChronic oedemaEdema resultsControl animalsEdemaInterstitial fluid pressure
2005
Risk stratification models fail to predict hospital costs of cardiac surgery patients
Hekmat K, Raabe A, Kroener A, Fischer U, Suedkamp M, Geissler H, Schwinger R, Kampe S, Mehlhorn U. Risk stratification models fail to predict hospital costs of cardiac surgery patients. Clinical Research In Cardiology 2005, 94: 748-753. PMID: 16258777, DOI: 10.1007/s00392-005-0300-8.Peer-Reviewed Original ResearchConceptsRisk stratification modelLength of stayTotal hospital costsCardiac surgical patientsHospital costsStratification modelSurgical patientsICU LOSCardiac surgery patientsConsecutive adult patientsPreoperative diagnostic testsICU staySurgery patientsAdult patientsCardiac surgeryRisk stratificationSpearman correlation coefficientProspective studyMean ageResultsA totalMethodsBetween OctoberMortality ratePatientsLinear regression analysisRoom costsMild Hypothermia Impairs Left Ventricular Diastolic but Not Systolic Function
Fischer U, Cox C, Laine G, Mehlhorn U, Allen S. Mild Hypothermia Impairs Left Ventricular Diastolic but Not Systolic Function. Journal Of Investigative Surgery 2005, 18: 291-296. PMID: 16319049, DOI: 10.1080/08941930500327047.Peer-Reviewed Original ResearchConceptsPreload recruitable stroke workSystolic functionCardiopulmonary bypassCardiac outputCardioplegic arrestBody temperatureEarly post-CPB periodPost-CPB periodImpact of hypothermiaLeft ventricular functionRecruitable stroke workDP/Ventricular diastolicDiastolic functionCardiac dysfunctionVentricular functionLV diastolicHYPO groupCPB periodMyocardial protectionAnesthetized dogsMild hypothermiaStroke workLV micromanometerBaseline levels
2004
The effect of preoperative antiplatelet therapy in coronary artery surgery: blood transfusion requirements for patients on cardiopulmonary bypass
Hekmat K, Menzel C, Kroener A, Schwinger R, Kampe S, Fischer U, Geissler H, Mehlhorn U. The effect of preoperative antiplatelet therapy in coronary artery surgery: blood transfusion requirements for patients on cardiopulmonary bypass. Current Medical Research And Opinion 2004, 20: 1429-1435. PMID: 15383191, DOI: 10.1185/030079904x2060.Peer-Reviewed Original ResearchConceptsAntiplatelet therapyCardiopulmonary bypassTransfusion requirementsControl patientsHomologous blood requirementsMediastinal tube drainagePreoperative antiplatelet therapyBlood transfusion requirementsCoronary artery bypassCoronary artery surgeryCoronary bypass surgeryFresh frozen plasma unitsAPT groupFrozen plasma unitsIntra-operative dataAPT therapyCON patientsElective CABGArtery bypassArtery surgeryBypass surgeryCommon complicationHospital dischargeTube drainageBlood lossMyocardial apoptosis prevention by radical scavenging in patients undergoing cardiac surgery
Fischer U, Tossios P, Huebner A, Geissler H, Bloch W, Mehlhorn U. Myocardial apoptosis prevention by radical scavenging in patients undergoing cardiac surgery. Journal Of Thoracic And Cardiovascular Surgery 2004, 128: 103-108. PMID: 15224028, DOI: 10.1016/j.jtcvs.2003.11.034.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAgedApoptosisCardiopulmonary BypassCaspase 3Caspase 7CaspasesCoronary Artery BypassCoronary Artery DiseaseDouble-Blind MethodEnzyme ActivationFemaleFree Radical ScavengersHeart RateHumansMaleMiddle AgedMyocardiumMyocytes, CardiacTreatment OutcomeVascular ResistanceVentricular Function, LeftVentricular PressureConceptsVentricular biopsy samplesN-acetylcysteineCardioplegic arrestBiopsy samplesCoronary artery bypass graft patientsLeft ventricular cardiac myocytesCardiac surgery patientsBypass graft patientsDouble-blind fashionConfidence intervalsCaspase-3Apoptosis inductionVentricular cardiac myocytesOxygen-derived speciesGraft patientsGray unitsSurgery patientsCardiac surgeryCardiopulmonary bypassClinical outcomesActive caspase-3Myocardial ischemiaApoptosis signal cascadePatientsCardiac myocytes
2003
Regional hypothermia reduces mucosal NF-κB and PMN priming via gut lymph during canine mesenteric Ischemia/Reperfusion1,2 1This paper was presented at the annual meeting of the Association for Academic Surgery, November 7–9, 2002, Boston, MA. 2Supported in part by NIGMS grants P50 GM38529-01, KO8 GM000675, and T32 GM08792.
Hassoun H, Fischer U, Attuwaybi B, Moore F, Safi H, Allen S, Cox C. Regional hypothermia reduces mucosal NF-κB and PMN priming via gut lymph during canine mesenteric Ischemia/Reperfusion1,2 1This paper was presented at the annual meeting of the Association for Academic Surgery, November 7–9, 2002, Boston, MA. 2Supported in part by NIGMS grants P50 GM38529-01, KO8 GM000675, and T32 GM08792. Journal Of Surgical Research 2003, 115: 121-126. PMID: 14572782, DOI: 10.1016/s0022-4804(03)00298-1.Peer-Reviewed Original ResearchConceptsTransvascular protein clearancePMN superoxide productionGut lymphIntraischemic hypothermiaNF-kappaB DNAProtein clearancePMN primingFistula modelRegional hypothermiaMesenteric ischemia/reperfusionSuperoxide productionPolymorphonuclear neutrophil (PMN) primingRemote organ injuryPro-inflammatory mediatorsMin of reperfusionEnd of ischemiaIschemia/reperfusionNF-kappaB activationNF-kappaB activityMesenteric ischemiaNeutrophil primingH reperfusionOrgan injuryReperfusion injuryMin reperfusionCardioplegic arrest induces apoptosis signal-pathway in myocardial endothelial cells and cardiac myocytes
Fischer U, Klass O, Stock U, Easo J, Geissler H, Fischer J, Bloch W, Mehlhorn U. Cardioplegic arrest induces apoptosis signal-pathway in myocardial endothelial cells and cardiac myocytes. European Journal Of Cardio-Thoracic Surgery 2003, 23: 984-990. PMID: 12829076, DOI: 10.1016/s1010-7940(03)00113-1.Peer-Reviewed Original ResearchNitrotyrosine and 8-isoprostane formation indicate free radical-mediated injury in hearts of patients subjected to cardioplegia
Mehlhorn U, Krahwinkel A, Geissler H, LaRosee K, Fischer U, Klass O, Suedkamp M, Hekmat K, Tossios P, Bloch W. Nitrotyrosine and 8-isoprostane formation indicate free radical-mediated injury in hearts of patients subjected to cardioplegia. Journal Of Thoracic And Cardiovascular Surgery 2003, 125: 178-183. PMID: 12539002, DOI: 10.1067/mtc.2003.97.Peer-Reviewed Original ResearchConceptsEnd of bypassCardiopulmonary bypassCyclic guanosine monophosphateMyocardial ischemiaIntermittent cold blood cardioplegiaConstitutive nitric oxide synthaseNitric oxide synthase activityNitric oxide synthase activationCyclic guanosine monophosphate contentOxygen-derived free radicalsCardiac myocytesCoronary endothelial injuryCoronary artery operationsFree radical-mediated lipid peroxidationCold blood cardioplegiaFree radical-mediated injuryGuanosine monophosphateHearts of patientsOxide synthase activityNitric oxide synthaseRadical-mediated lipid peroxidationVentricular biopsy specimensRadical-mediated injuryNitric oxide releaseBlood cardioplegia
2002
Impact of cardiopulmonary bypass management on postcardiac surgery renal function
Fischer U, Weissenberger W, Warters R, Geissler H, Allen S, Mehlhorn U. Impact of cardiopulmonary bypass management on postcardiac surgery renal function. Perfusion 2002, 17: 401-406. PMID: 12470028, DOI: 10.1191/0267659102pf610oa.Peer-Reviewed Original ResearchConceptsPostoperative acute renal failureAcute renal failureNormal preoperative renal functionPreoperative renal functionPostoperative renal dysfunctionPostoperative renal functionRenal functionCardiopulmonary bypassCPB durationRenal dysfunctionCPB flowArterial pressurePerfusion pressurePerioperative low cardiac output syndromeCPB managementLow cardiac output syndromeNormal postoperative renal functionLonger CPB durationMean arterial pressureCardiac surgical proceduresGroup of patientsCardiopulmonary bypass managementFuture clinical studiesARF preventionOutput syndrome
2001
Impact of myocardial protection during coronary bypass surgery on patient outcome
Mehlhorn U, Fattah M, Kuhn-Régnier F, Südkamp M, Geissler H, Raji M, Fischer U, de Vivie E. Impact of myocardial protection during coronary bypass surgery on patient outcome. Vascular 2001, 9: 482-486. PMID: 11489654, DOI: 10.1016/s0967-2109(01)00024-2.Peer-Reviewed Original ResearchConceptsCoronary artery surgeryConventional cardioplegiaArtery surgeryMyocardial protectionRenal failureNeurological symptomsPatient outcomesUltra-short acting beta-blocker esmololIntensive care unit stayPerioperative myocardial infarction ratePreoperative left ventricular functionRoutine coronary artery surgeryBeta-blocker esmololTotal hospital stayPostoperative renal failureCoronary bypass surgeryMyocardial infarction rateContinuous coronary perfusionLeft ventricular functionMyocardial protection techniquesIntensive care unitMechanical circulatory supportPositive inotropic medicationTime of mobilizationCardioplegia technique