Beyond the Descriptive: A Comprehensive, Multi-domain Validation of Symptom Trajectories for Individuals at Clinical High Risk for Psychosis
Deng W, Chong B, Addington J, Bearden C, Cadenhead K, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S, Cannon T. Beyond the Descriptive: A Comprehensive, Multi-domain Validation of Symptom Trajectories for Individuals at Clinical High Risk for Psychosis. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024 PMID: 39260565, DOI: 10.1016/j.bpsc.2024.08.020.Peer-Reviewed Original ResearchClinical high riskCHR-PTrajectory groupsMaintenance of symptomsOnset of psychosisNon-convertersHealthy controlsDiagnostic constructSymptom trajectoriesPsychosisAffective comorbiditiesAssess symptomsHeightened riskFunctional impairmentSymptomsEtiological risk factorsFunctional outcomesImminent onsetLevels of intensityRemissionRisk factorsIndividualsPhase 3DistressImpairmentLongitudinal Trajectories of Premorbid Social and Academic Adjustment in Youth at Clinical High Risk for Psychosis: Implications for Conversion
Cowan H, Mittal V, Addington J, Bearden C, Cadenhead K, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Tsuang M, Woods S, Cannon T, Walker E. Longitudinal Trajectories of Premorbid Social and Academic Adjustment in Youth at Clinical High Risk for Psychosis: Implications for Conversion. Schizophrenia Bulletin 2024, sbae050. PMID: 38706103, DOI: 10.1093/schbul/sbae050.Peer-Reviewed Original ResearchConversion to psychosisClinical high riskAcademic adjustmentPremorbid periodPremorbid adjustmentNegative symptomsNon-convertersSocial adjustmentLongitudinal trajectoriesChildhood trauma impactsPremorbid adjustment trajectoriesPremorbid social functioningPoor academic adjustmentBetween-person levelPsychotic disorder diagnosisNon-affective psychosisPoor social adjustmentGrowth curve modelsPsychotic disordersPremorbid functioningChildhood traumaDisorder diagnosisCognitive effectsPsychosisAdjustment problems