The Complex Latent Structure of Attenuated Psychotic Symptoms: Hierarchical and Bifactor Models of SIPS Symptoms Replicated in Two Large Samples at Clinical High Risk for Psychosis
Cowan H, Williams T, Mittal V, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshevan M, Perkins D, Mathalon D, Stone W, Woods S, Walker E. The Complex Latent Structure of Attenuated Psychotic Symptoms: Hierarchical and Bifactor Models of SIPS Symptoms Replicated in Two Large Samples at Clinical High Risk for Psychosis. Schizophrenia Bulletin 2024, sbae042. PMID: 38728417, DOI: 10.1093/schbul/sbae042.Peer-Reviewed Original ResearchAttenuated psychotic symptomsClinical high riskPsychotic symptomsGeneral factorBifactor modelPsychosis riskPsychotic disordersPresence of attenuated psychotic symptomsFunctional impairmentConversion to psychotic disordersAssessment of psychosis riskPositive symptom factorNon-psychotic symptomsPsychosis-Risk SyndromesAssociated with depressive symptomsCHR participantsPositive symptomsCHR statusCHR samplesSymptom varianceTransdiagnostic assessmentInternalizing symptomsSymptom factorsPreregistered replicationDepressive symptomsProteomic Biomarkers for the Prediction of Transition to Psychosis in Individuals at Clinical High Risk: A Multi-cohort Model Development Study
Byrne J, Healy C, Föcking M, Susai S, Mongan D, Wynne K, Kodosaki E, Heurich M, de Haan L, Hickie I, Smesny S, Thompson A, Markulev C, Young A, Schäfer M, Riecher-Rössler A, Mossaheb N, Berger G, Schlögelhofer M, Nordentoft M, Chen E, Verma S, Nieman D, Woods S, Cornblatt B, Stone W, Mathalon D, Bearden C, Cadenhead K, Addington J, Walker E, Cannon T, Cannon M, McGorry P, Amminger P, Cagney G, Nelson B, Jeffries C, Perkins D, Cotter D. Proteomic Biomarkers for the Prediction of Transition to Psychosis in Individuals at Clinical High Risk: A Multi-cohort Model Development Study. Schizophrenia Bulletin 2024, 50: 579-588. PMID: 38243809, PMCID: PMC11059811, DOI: 10.1093/schbul/sbad184.Peer-Reviewed Original ResearchClinical high riskTransition to psychosisAssociated with transition to psychosisClinical high-risk cohortNorth American Prodrome Longitudinal Study 2Predicting transition to psychosisDevelopment of psychosisLongitudinal Study 2Group levelPlasma proteomics dataCHR participantsPsychosis riskPrediction of transitionPsychosisStudy 2High riskLongitudinal associationsStudy follow-up periodRandomized controlled trialsLogistic regression modelsMultiple comparisonsPrimary outcomeProteomic biomarkersControlled trialsGlycoprotein 1