A Bimodal Nanosensor for Probing Influenza Fusion Protein Activity Using Magnetic Relaxation
Jain V, Shelby T, Patel T, Mekhedov E, Petersen J, Zimmerberg J, Ranaweera A, Weliky D, Dandawate P, Anant S, Sulthana S, Vasquez Y, Banerjee T, Santra S. A Bimodal Nanosensor for Probing Influenza Fusion Protein Activity Using Magnetic Relaxation. ACS Sensors 2021, 6: 1899-1909. PMID: 33905237, DOI: 10.1021/acssensors.1c00253.Peer-Reviewed Original ResearchConceptsHigh-resolution cryo-TEMMagnetic relaxation timesAspects of fusionProtein/lipid interactionsMagnetic relaxationRelaxation timeNMR instrumentProtein-lipid interactionsFusion processFluorescence-based methodPotential fusion inhibitorsFusion mechanismExperimental timeRelaxationT2 relaxationNanosensorsLipid interactionsReal-time monitoringDynamic eventsInteractionMinute interactionCryo-TEMReal timeParticles