Phosphatidylinositol and phosphatidylinositol-3-phosphate activate HOPS to catalyze SNARE assembly, allowing small headgroup lipids to support the terminal steps of membrane fusion.
Torng T, Wickner W. Phosphatidylinositol and phosphatidylinositol-3-phosphate activate HOPS to catalyze SNARE assembly, allowing small headgroup lipids to support the terminal steps of membrane fusion. Molecular Biology Of The Cell 2021, 32: ar19. PMID: 34495682, PMCID: PMC8693972, DOI: 10.1091/mbc.e21-07-0373.Peer-Reviewed Original ResearchMeSH KeywordsCatalysisInositol PhosphatesIntracellular MembranesMembrane FusionMolecular ChaperonesPhosphatesPhosphatidic AcidsPhosphatidylinositol PhosphatesPhosphatidylinositolsProtein BindingProteolipidsRab GTP-Binding ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSNARE ProteinsSoluble N-Ethylmaleimide-Sensitive Factor Attachment ProteinsVacuolesVesicular Transport ProteinsConceptsSNARE complex assembly