2014
Proteomic identification of 14‐3‐3ϵ as a linker protein between pERK1/2 inhibition and BIM upregulation in human osteosarcoma cells
Kim KO, Hsu AC, Lee HG, Patel N, Chandhanayingyong C, Hickernell T, Lee F. Proteomic identification of 14‐3‐3ϵ as a linker protein between pERK1/2 inhibition and BIM upregulation in human osteosarcoma cells. Journal Of Orthopaedic Research® 2014, 32: 848-854. PMID: 24536031, DOI: 10.1002/jor.22598.Peer-Reviewed Original ResearchConceptsPERK1/2 inhibitionHuman osteosarcoma cellsBim expressionSubset of patientsOsteosarcoma cellsConventional cytotoxic agentsConventional cytotoxic treatmentAnti-cancer effectsInhibition of pERK1/2Pro-apoptotic mechanismsMultifocal osteosarcomaMultimodality chemotherapyCytotoxic treatmentUpregulation of BimOsteosarcoma treatmentOsteosarcoma cell deathCytotoxic agentsExpression of BimPotential mediatorsTreatment of PD98059UpregulationTreatmentPD98059 treatmentInhibitionCell death
2010
Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome
Rucci F, Notarangelo L, Fazeli A, Patrizi L, Hickernell T, Paganini T, Coakley K, Detre C, Keszei M, Walter J, Feldman L, Cheng H, Poliani P, Wang J, Balter B, Recher M, Andersson E, Zha S, Giliani S, Terhorst C, Alt F, Yan C. Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 3024-3029. PMID: 20133615, PMCID: PMC2840307, DOI: 10.1073/pnas.0914865107.Peer-Reviewed Original ResearchConceptsLIG4 mutationsGrowth retardationPeripheral T lymphocytesLIG4 syndromeLow-affinity antibodiesLeaky SCIDHomozygous mutant miceAnergic phenotypeHigh-affinity antibodiesT lymphocytesMouse modelB cell developmentMutant miceDevelopmental delayDecreased life spanTumor developmentFacial dysmorphismLymphocyte developmentMiceAutoreactive specificitiesNonhomologous end-joining repair pathwaySyndromeHigh rateSCIDVariable degrees