2021
Biocompatibility of nanomaterials and their immunological properties
Kyriakides TR, Raj A, Tseng TH, Xiao H, Nguyen R, Mohammed FS, Halder S, Xu M, Wu MJ, Bao S, Sheu WC. Biocompatibility of nanomaterials and their immunological properties. Biomedical Materials 2021, 16: 042005. PMID: 33578402, PMCID: PMC8357854, DOI: 10.1088/1748-605x/abe5fa.Peer-Reviewed Original ResearchConceptsMetal/metal oxideBiocompatibility of nanomaterialsNanomaterialsNovel sensingMetal oxidesBiocompatibilityOverall biocompatibilityBulk materialClinical trialsOccupational exposureTherapeutic approachesSystemic effectsNanotoxicityClinical useFabricationPutative negative effectsImmunological propertiesSensingCell typesOxideLiposomesHost proteinsReciprocal interactionsApplicationsCarbon
2018
Hierarchical Micro- and Nanopatterning of Metallic Glass to Engineer Cellular Responses
Wang J, Loye A, Ketkaew J, Schroers J, Kyriakides T. Hierarchical Micro- and Nanopatterning of Metallic Glass to Engineer Cellular Responses. ACS Applied Bio Materials 2018, 1: 51-58. DOI: 10.1021/acsabm.8b00007.Peer-Reviewed Original ResearchHierarchical microNano/micro levelTopographical length scalesLength scalesMechanical propertiesMultiple length scalesPt-BMGMetallic glassesWetting abilityRelevant length scalesForeign body responseNanotopographical featuresCellular responsesAmorphous natureEngineering sciencesSpecific cell responsesMicroSubstrateCell behaviorCell typesMorphology of macrophagesMacrophage fusionCell morphologyNanopatterningBiomaterials
2015
Chapter 5 Molecular Events at Tissue–Biomaterial Interface
Kyriakides T. Chapter 5 Molecular Events at Tissue–Biomaterial Interface. 2015, 81-116. DOI: 10.1016/b978-0-12-800196-7.00005-0.Peer-Reviewed Original ResearchMolecular eventsIntracellular molecular pathwaysInteraction of proteinsKey inflammatory cell typeProduction of signalsAssociated proteinsProtein altersAltered conformationTissue-biomaterial interfaceConformational changesCell adhesionMolecular pathwaysCell typesProteinProteinaceous coatingsCell functionMolecular interactionsCell receptorCurrent understandingBiomaterial interactionsMatrix depositionActivationEventual encapsulationResident cellsCells
2014
Engineering Cellular Response Using Nanopatterned Bulk Metallic Glass
Padmanabhan J, Kinser ER, Stalter MA, Duncan-Lewis C, Balestrini JL, Sawyer AJ, Schroers J, Kyriakides TR. Engineering Cellular Response Using Nanopatterned Bulk Metallic Glass. ACS Nano 2014, 8: 4366-4375. PMID: 24724817, PMCID: PMC4046793, DOI: 10.1021/nn501874q.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiocompatible MaterialsBiomechanical PhenomenaCell AdhesionCell SurvivalCollagenCytoskeletonFibroblastsFibronectinsForeign-Body ReactionGlassGTP PhosphohydrolasesHuman Umbilical Vein Endothelial CellsHumansMetalsMiceMicroscopy, FluorescenceNanostructuresNanotechnologyNIH 3T3 CellsProtein EngineeringRhoA GTP-Binding ProteinConceptsBulk metallic glassCellular responsesFeature sizeMetallic glassesFocal adhesion densityCell traction forcesCytoskeletal remodelingFIB-SEM techniqueSubstrate stiffnessBiomechanical cuesThermoplastic formingMolecular pathwaysCell typesVersatile fabricationNondimensional analysisSubstrate nanotopographyCellular morphologyCell morphologyBiocompatible materialsCell functionForeign body responseNanoscale precisionCell sizeTissue repairFibroblasts