Alzheimer disease periventricular white matter lesions exhibit specific proteomic profile alterations
Castaño E, Maarouf C, Wu T, Leal M, Whiteside C, Lue L, Kokjohn T, Sabbagh M, Beach T, Roher A. Alzheimer disease periventricular white matter lesions exhibit specific proteomic profile alterations. Neurochemistry International 2012, 62: 145-156. PMID: 23231993, PMCID: PMC3568229, DOI: 10.1016/j.neuint.2012.12.001.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseWhite matterNDC subjectsPeriventricular white matter lesionsCourse of ADGlial fibrillary acidic proteinPeriventricular white matterCollapsin response mediator protein 2White matter lesionsResponse mediator protein 2Fibrillary acidic proteinGray matter functionΕ3/3 genotypeAxonal lossMyelin lossAD dementiaDementia pathogenesisMatter lesionsMean ageAD pathologyCalcium metabolismPeriventricular WMPathologic basisAD subjectsWM alterations