1988
Synthetic human parathyroid hormone-like protein stimulates bone resorption and causes hypercalcemia in rats.
Stewart AF, Mangin M, Wu T, Goumas D, Insogna KL, Burtis WJ, Broadus AE. Synthetic human parathyroid hormone-like protein stimulates bone resorption and causes hypercalcemia in rats. Journal Of Clinical Investigation 1988, 81: 596-600. PMID: 3339131, PMCID: PMC329608, DOI: 10.1172/jci113358.Peer-Reviewed Original ResearchConceptsBone-resorbing agentsMicrograms/hParathyroid hormone-like proteinFetal rat long bonesAdenylate cyclasePotent bone-resorbing agentHormone-like proteinRat long bonesMembrane adenylate cyclaseSerum calciumHumoral hypercalcemiaOsmotic minipumpsBone resorptionPotent agonistLong bonesSuch synthetic peptidesHypercalcemiaRatsDlVivo bioactivityCyclaseSynthetic peptidesAgentsMinipumpsPatients
1987
Two forms of parathyroid hormone‐like adenylate cyclase‐stimulating protein derived from tumors associated with humoral hypercalcemia of malignancy
Stewart A, Burtis W, Wu T, Goumas D, Broadus A. Two forms of parathyroid hormone‐like adenylate cyclase‐stimulating protein derived from tumors associated with humoral hypercalcemia of malignancy. Journal Of Bone And Mineral Research 1987, 2: 587-593. PMID: 3455636, DOI: 10.1002/jbmr.5650020616.Peer-Reviewed Original ResearchN-Terminal amino acid sequence of two novel tumor-derived adenylate cyclase-stimulating proteins: Identification of parathyroid hormone-like and parathyroid hormone-unlike domains
Stewart A, Wu T, Goumas D, Burtis W, Broadus A. N-Terminal amino acid sequence of two novel tumor-derived adenylate cyclase-stimulating proteins: Identification of parathyroid hormone-like and parathyroid hormone-unlike domains. Biochemical And Biophysical Research Communications 1987, 146: 672-678. PMID: 3619898, DOI: 10.1016/0006-291x(87)90581-x.Peer-Reviewed Original ResearchIdentification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy.
Burtis WJ, Wu T, Bunch C, Wysolmerski JJ, Insogna KL, Weir EC, Broadus AE, Stewart AF. Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy. Journal Of Biological Chemistry 1987, 262: 7151-7156. PMID: 3584110, DOI: 10.1016/s0021-9258(18)48217-8.Peer-Reviewed Original ResearchThe relative potency of a human tumor‐derived PTH‐like adenylate cyclase‐stimulating preparation in three bioassays
Stewart A, Wu T, Burtis W, Weir E, Broadus A, Insogna K. The relative potency of a human tumor‐derived PTH‐like adenylate cyclase‐stimulating preparation in three bioassays. Journal Of Bone And Mineral Research 1987, 2: 37-43. PMID: 3455155, DOI: 10.1002/jbmr.5650020107.Peer-Reviewed Original ResearchConceptsFetal bone resorptionRat osteosarcomaPTH standardRelative potencyCyclase assaysPTH target tissuesAdenylate cyclase assayHumoral hypercalcemiaBone resorptionPTH receptorBPTH 1Target tissuesDistinct subpopulationsPotencyAssaysHypercalcemiaPrevious studiesMalignancyOsteosarcomaTumorsResorptionReceptors