2024
A Pilot Study on the Proteomics Profile of Serum Exosome-Enriched Extracellular Vesicles from Normal versus Individuals with Obesity-Related Insulin Resistance
Saraswathi V, Ai W, Kumar V, Sharma K, Gopal T, Kumar N, Malhi H, Sehrawat T, Desouza C. A Pilot Study on the Proteomics Profile of Serum Exosome-Enriched Extracellular Vesicles from Normal versus Individuals with Obesity-Related Insulin Resistance. Biomedicines 2024, 12: 799. PMID: 38672154, PMCID: PMC11048419, DOI: 10.3390/biomedicines12040799.Peer-Reviewed Original ResearchObesity-related insulin resistanceIngenuity Pathway AnalysisInsulin resistanceB cellsRegulate immune cell activationSerum exosomesImmune cell activationIsolated serum exosomesB cell activationRisk of diabetesHigh-risk individualsExosome-enriched extracellular vesiclesProteomic profilingProgression of diabetesIngenuity Pathway Analysis analysesCell activationInsulin sensitivityProtein expressionOB-IRExosomal proteinsTherapeutic targetMale subjectsExtracellular vesiclesExtracellular spaceInflammation
2022
THU033 Improving NIAAA criteria for the diagnosis of alcoholic hepatitis, role of systemic inflammation
Pose E, Avitabile E, Díaz A, Montironi C, Perez M, Gratacós-Gines J, Evole H, Sehrawat T, Malhi H, Olivas P, Hernandez-Gea V, Shah V, Kamath P, Ginès P. THU033 Improving NIAAA criteria for the diagnosis of alcoholic hepatitis, role of systemic inflammation. Journal Of Hepatology 2022, 77: s136-s137. DOI: 10.1016/s0168-8278(22)00653-5.Peer-Reviewed Original Research
2021
Circulating extracellular vesicles are a biomarker for NAFLD resolution and response to weight loss surgery
Nakao Y, Amrollahi P, Parthasarathy G, Mauer A, Sehrawat T, Vanderboom P, Nair K, Nakao K, Allen A, Hu T, Malhi H. Circulating extracellular vesicles are a biomarker for NAFLD resolution and response to weight loss surgery. Nanomedicine Nanotechnology Biology And Medicine 2021, 36: 102430. PMID: 34174416, PMCID: PMC8418232, DOI: 10.1016/j.nano.2021.102430.Peer-Reviewed Original ResearchConceptsWeight loss surgeryHepatocyte-derived extracellular vesiclesPlasma levelsNAFLD resolutionExtracellular vesiclesWeight loss patientsLogistic regression analysisPlasma extracellular vesiclesNAFLD patientsLipid panelNASH patientsLoss patientsNAFLDInvasive biomarkersPatientsCare testGroup 22EV correlatesSteatosisSurgeryRegression analysisBiomarkersDifferential ultracentrifugationCorrelatesInflammation