Rapid chelator-free radiolabeling of quantum dots for in vivo imaging
Tang T, Wei Y, Yang Q, Yang Y, Sailor M, Pang H. Rapid chelator-free radiolabeling of quantum dots for in vivo imaging. Nanoscale 2019, 11: 22248-22254. PMID: 31746913, DOI: 10.1039/c9nr08508d.Peer-Reviewed Original ResearchConceptsChelator-free radiolabelingQuantum dotsZinc sulfide quantum dotsSulfide quantum dotsNanoparticle surfaceSurface functionalizationAqueous solutionHigh labeling efficiencyMetal chelationCation exchangeRadiolabeling approachChemical propertiesCellular uptakeMetal chelatorsLabeling efficiencyDotsVivo PET imagingHigh tumor uptakeMurine cancer modelsRadiochemical purityRadiolabelingNanoparticlesFunctionalizationChelatorsChelationTumor-specific macrophage targeting through recognition of retinoid X receptor beta
Tang T, Wei Y, Kang J, She Z, Kim D, Sailor M, Ruoslahti E, Pang H. Tumor-specific macrophage targeting through recognition of retinoid X receptor beta. Journal Of Controlled Release 2019, 301: 42-53. PMID: 30871996, PMCID: PMC6500479, DOI: 10.1016/j.jconrel.2019.03.009.Peer-Reviewed Original ResearchConceptsRetinoid X receptor betaTumor macrophagesSystemic administrationReceptor betaNormal macrophage functionCancer therapyTumor-bearing miceTumor-selective bindingCell surface markersNovel cell surface markersMacrophage modulationMacrophage functionSolid tumorsTumor-specific mannerMacrophage typesSurface markersMacrophagesCancer progressionTumorsHealthy organsNuclear receptorsTherapyAdministrationCell surface localizationReceptors