2010
Role of Metabolic Activation and the TRPA1 Receptor in the Sensory Irritation Response to Styrene and Naphthalene
Lanosa M, Willis D, Jordt S, Morris J. Role of Metabolic Activation and the TRPA1 Receptor in the Sensory Irritation Response to Styrene and Naphthalene. Toxicological Sciences 2010, 115: 589-595. PMID: 20176620, PMCID: PMC2948824, DOI: 10.1093/toxsci/kfq057.Peer-Reviewed Original ResearchConceptsSensory irritation responseIrritation responseTransient receptor potential ankyrin 1 receptorMetabolic activationFemale C57BL/6J miceCytochrome P450 activationTRPA1 receptorsC57BL/6J miceCYP450 metabolitesPlethysmographic measurementsPpm styreneSensory irritationInhibitor metyraponeP450 activationPpm naphthaleneReceptorsMiceActivationCurrent studyCritical roleResponseMetyraponeIrritationRole
1997
Molecular dissection of gating in the ClC‐2 chloride channel
Jordt S, Jentsch T. Molecular dissection of gating in the ClC‐2 chloride channel. The EMBO Journal 1997, 16: 1582-1592. PMID: 9130703, PMCID: PMC1169762, DOI: 10.1093/emboj/16.7.1582.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCell MembraneChloride ChannelsConsensus SequenceHydrogen-Ion ConcentrationIon Channel GatingMembrane PotentialsModels, StructuralMolecular Sequence DataMutagenesis, Site-DirectedOocytesPatch-Clamp TechniquesPoint MutationProtein Structure, SecondaryRatsRecombinant Fusion ProteinsXenopus laevisConceptsChloride channelsClC-2 chloride channelSite-directed mutagenesisMolecular dissectionEquivalent mutationCytoplasmic loopMode of activationClC-0ClC-2Gating mechanismInactivation domainMutationsCell swellingActivationNeuronal excitabilityMutagenesisTransmembraneCell volumeDeletionRegulationPathwayFinal pathwayMechanismVoltage dependenceOutward rectification