Sven-Eric Jordt, PhD
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About
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Associate Professor of Anesthesiology, Pharmacology & Cancer Biology, University Program of Environmental Health (UPEH)
Biography
Dr. Jordt is Associate Professor (Adjunct) of Psychiatry and research project director and teaching faculty member for the Yale Tobacco Center of Regulatory Science (TCORS).
His main affiliation is with Duke University, where he joined the Department of Anesthesiology in the School of Medicine in April 2014.
Research in the Jordt laboratory focuses on mechanisms of chemical sensing and their role in pain, inflammation, respiratory system function and in the adverse health effects of toxic chemicals.
Education & Training
- PhD
- Free University Berlin (1997)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Sven-Eric Jordt's published research.
Publications Timeline
A big-picture view of Sven-Eric Jordt's research output by year.
Hanno C. Erythropel, PhD
Julie Zimmerman
Lauren Cohn, MD
Barry G Green, PhD
Grace Kong, PhD
Kristopher Kahle, MD, PhD
76Publications
10,206Citations
Publications
2024
An Electronic Cigarette Pod System Delivering 6-methyl Nicotine, A Synthetic Nicotine Analog, Marketed in the United States as "PMTA Exempt"
Jordt S, Silinski P, Berman M. An Electronic Cigarette Pod System Delivering 6-methyl Nicotine, A Synthetic Nicotine Analog, Marketed in the United States as "PMTA Exempt". 2024, a2135-a2135. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2135.Peer-Reviewed Original ResearchConceptsSpree Bar, a vaping system delivering a synthetic nicotine analogue, marketed in the USA as ‘PMTA exempt’
Jordt S, Jabba S, Zettler P, Berman M. Spree Bar, a vaping system delivering a synthetic nicotine analogue, marketed in the USA as ‘PMTA exempt’. Tobacco Control 2024, tc-2023-058469. PMID: 38499343, DOI: 10.1136/tc-2023-058469.Peer-Reviewed Original ResearchCitationsAltmetricVagus nerve stimulation rescues persistent pain following orthopedic surgery in adult mice.
Wu P, Caceres A, Chen J, Sokoloff J, Huang M, Baht G, Nackley A, Jordt S, Terrando N. Vagus nerve stimulation rescues persistent pain following orthopedic surgery in adult mice. Pain 2024, 165: e80-e92. PMID: 38422485, PMCID: PMC11247455, DOI: 10.1097/j.pain.0000000000003181.Peer-Reviewed Original ResearchAltmetricConceptsDorsal root gangliaPostoperative painVagus nerve stimulationPain behaviorOrthopedic surgeryNerve stimulationHindpaw mechanical allodyniaPrevent postoperative painFemale C57BL/6J miceOrthopedic trauma surgeryMechanical allodyniaAntinociceptive effectPersistent painAccelerated bone healingAnalgesic effectAdult miceC57BL/6J miceEffective therapyNeuropeptide levelsSpinal cordMouse modelSatellite cellsSurgeryPainVagus nerveRecapitulation of human pathophysiology and identification of forensic biomarkers in a translational model of chlorine inhalation injury
Achanta S, Gentile M, Albert C, Schulte K, Pantazides B, Crow B, Quiñones-González J, Perez J, Ford D, Patel R, Blake T, Gunn M, Jordt S. Recapitulation of human pathophysiology and identification of forensic biomarkers in a translational model of chlorine inhalation injury. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2024, 326: l482-l495. PMID: 38318664, DOI: 10.1152/ajplung.00162.2023.Peer-Reviewed Original ResearchCitationsAltmetricConceptsAcute lung injuryBronchoalveolar lavage fluidChlorine gasChlorinated fatty acidsDecreased dynamic lung complianceHuman acute lung injuryPeak inspiratory pressureIncreased airway resistanceMedical countermeasuresControlled mechanical ventilationForensic biomarkersDynamic lung complianceFormation of microthrombiProtein adductsAir-exposed groupNeutrophilic alveolitisTesting medical countermeasuresVascular leakageNeutrophil countPulmonary edemaHistopathological featuresPotential medical countermeasuresForensic analysisInspiratory pressureLung injury
2023
Pharmacologic inhibition of TRPA1 counteract tear gas induced cutaneous injuries
Achanta S, Chintagari N, Balakrishna S, Liu B, Jordt S. Pharmacologic inhibition of TRPA1 counteract tear gas induced cutaneous injuries. Journal Of Pharmacology And Experimental Therapeutics 2023, 388: jpet-ar-2023-001666. PMID: 38050077, PMCID: PMC10801748, DOI: 10.1124/jpet.123.001666.Peer-Reviewed Original ResearchCitationsAltmetricConceptsTransient receptor potential ankyrin 1Tear gas agentsCutaneous injurySkin injuryTRPA1 antagonistTRPA1 inhibitor HC-030031Injury parametersWeek old C57BL/6 male miceInflammatory cytokine levelsC57BL/6 male miceTherapeutic efficacy studiesEffects of CSNeuronal ion channelsMouse ear skinTRPA1 inhibitionAirway obstructionNeurogenic inflammationCytokine levelsHC-030031Severe painPlasma extravasationCS exposureAcute irritationAcute toxic effectsFrequent injuriesTransient Receptor Potential channels (TRP) in GtoPdb v.2023.3
Blair N, Caceres A, Carvacho I, Chaudhuri D, Clapham D, De Clerq K, Delling M, Doerner J, Fan L, Grimm C, Ha K, Hu M, Jabba S, Jordt S, Julius D, Kahle K, Liu B, Liu Q, McKemy D, Nilius B, Oancea E, Owsianik G, Riccio A, Sah R, Stotz S, Tian J, Tong D, Vriens J, Wu L, Xu H, Yang F, Yang W, Yue L, Zhu M. Transient Receptor Potential channels (TRP) in GtoPdb v.2023.3. IUPHAR/BPS Guide To Pharmacology CITE 2023, 2023 DOI: 10.2218/gtopdb/f78/2023.3.Peer-Reviewed Original ResearchCitationsConceptsTRPC channelsTransient receptor potential channelsCongenital stationary night blindnessCalcium-activated cationStore-operated channelsAdenosine diphosphate riboseNumerous splice variantsNMDA receptorsActivate TRPA1Cation channelsIntracellular ATP levelsChannel activityMicromolar concentrations of La3+Neurodegenerative disorder mucolipidosis type IVDepletion of intracellular calcium storesMucolipidosis type IVTRP channelsRegulation of Ca2+ entryAssociated with conduction defectsDetection of noxious heatDevelopment of heat hyperalgesiaDevelopment of thermal hyperalgesiaDynamic intracellular vesicular structuresExtra-synaptic NMDA receptorsInvolvement of TRP channelsSynthetic Cooling Agent and Other Flavor Additives in “Non-Menthol” Cigarettes Marketed in California and Massachusetts After Menthol Cigarette Bans
Jabba S, Erythropel H, Anastas P, Zimmerman J, Jordt S. Synthetic Cooling Agent and Other Flavor Additives in “Non-Menthol” Cigarettes Marketed in California and Massachusetts After Menthol Cigarette Bans. JAMA 2023, 330: 1689-1691. PMID: 37812408, PMCID: PMC10562986, DOI: 10.1001/jama.2023.17134.Peer-Reviewed Original ResearchCitationsAltmetricThe Concise Guide to PHARMACOLOGY 2023/24: Ion channels
Alexander S, Mathie A, Peters J, Veale E, Striessnig J, Kelly E, Armstrong J, Faccenda E, Harding S, Davies J, Aldrich R, Attali B, Baggetta A, Becirovic E, Biel M, Bill R, Caceres A, Catterall W, Conner A, Davies P, De Clerq K, Delling M, Di Virgilio F, Falzoni S, Fenske S, Fortuny-Gomez A, Fountain S, George C, Goldstein S, Grimm C, Grissmer S, Ha K, Hammelmann V, Hanukoglu I, Hu M, Ijzerman A, Jabba S, Jarvis M, Jensen A, Jordt S, Kaczmarek L, Kellenberger S, Kennedy C, King B, Kitchen P, Liu Q, Lynch J, Meades J, Mehlfeld V, Nicke A, Offermanns S, Perez-Reyes E, Plant L, Rash L, Ren D, Salman M, Sieghart W, Sivilotti L, Smart T, Snutch T, Tian J, Trimmer J, Van den Eynde C, Vriens J, Wei A, Winn B, Wulff H, Xu H, Yang F, Fang W, Yue L, Zhang X, Zhu M. The Concise Guide to PHARMACOLOGY 2023/24: Ion channels. British Journal Of Pharmacology 2023, 180: s145-s222. PMID: 38123150, DOI: 10.1111/bph.16178.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBest available pharmacological toolsOpen access knowledgebase sourceOfficial IUPHAR classificationAvailable pharmacological toolsDrug targetsG protein-coupled receptorsIon channelsProtein-coupled receptorsNomenclature guidanceClinical pharmacologyMajor pharmacological targetCatalytic receptorsSelective pharmacologyNuclear hormone receptorsPharmacological targetsPharmacological toolsHormone receptorsPrevious GuidesReceptorsLandscape formatHuman drug targetsPharmacologyConcise guideBiennial publicationRelated targetsTransient Receptor Potential channels (TRP) in GtoPdb v.2023.2
Blair N, Caceres A, Carvacho I, Chaudhuri D, Clapham D, De Clerq K, Delling M, Doerner J, Fan L, Grimm C, Ha K, Hu M, Jabba S, Jordt S, Julius D, Kahle K, Liu B, Liu Q, McKemy D, Nilius B, Oancea E, Owsianik G, Riccio A, Sah R, Stotz S, Tian J, Tong D, Vriens J, Wu L, Xu H, Yang F, Yang W, Yue L, Zhu M. Transient Receptor Potential channels (TRP) in GtoPdb v.2023.2. IUPHAR/BPS Guide To Pharmacology CITE 2023, 2023 DOI: 10.2218/gtopdb/f78/2023.2.Peer-Reviewed Original ResearchConceptsTransient receptor potential channelsCongenital stationary night blindnessTRPC channelsAdenosine diphosphate riboseStore-operated channelsMost TRP channelsTRP channelsNMDA receptorsCation channelsIntracellular ATP levelsExtra-synaptic NMDA receptorsMetabotropic glutamate receptor 6Activation of GoHuman TRPM1 mutationsReabsorption of calciumTRPC4/C5Ion channelsExpression of S100A9Dendritic cell migrationBile duct diseaseIntracellular calcium storesActivity of TRPV1Layer 5 neuronsSynaptic NMDA receptorsMouse prefrontal cortexSynthetic cooling agent in oral nicotine pouch products marketed as ‘Flavour-Ban Approved’
Jabba S, Erythropel H, Woodrow J, Anastas P, O'Malley S, Krishnan-Sarin S, Zimmerman J, Jordt S. Synthetic cooling agent in oral nicotine pouch products marketed as ‘Flavour-Ban Approved’. Tobacco Control 2023, tc-2023-058035. PMID: 37380351, PMCID: PMC10753027, DOI: 10.1136/tc-2023-058035.Peer-Reviewed Original ResearchCitationsAltmetricConceptsGas chromatography/mass spectrometryChromatography/mass spectrometryWS-3Oral nicotine pouchesSynthetic coolantsMass spectrometryChemical analysisSensory irritancyFlavor additivesAdditivesChemical contentFlavoring agentProductsIrritant activitySpectrometryFlavourantsEffective strategyExtractAgentsNicotine pouches
Academic Achievements and Community Involvement
honor Leading Edge in Basic Science Award
International AwardSociety of ToxicologyDetails01/01/2019United Stateshonor Extension Award
International AwardAmerican Asthma Foundation (Sandler Foundation)Details01/01/2009United Stateshonor Presidential Early Career Award for Scientists and Engineers (PECASE)
National AwardPresident of the United StatesDetails11/01/2007United Stateshonor Early Excellence Award
International AwardAmerican Asthma Foundation (Sandler Foundation)Details05/15/2007United Stateshonor Outstanding New Environmental Scientist Award (ONES)
National AwardNational Institute of Environmental Health Sciences (NIEHS)Details09/01/2006United States
Links & Media
News
- June 03, 2024Source: Scientific American
How Tobacco Companies Use Chemistry To Get Around Menthol Bans
- September 27, 2023
$20M Federal Grant Renewed for Yale Tobacco Center of Regulatory Science
- March 08, 2022Source: The New York Times
The Loophole That’s Fueling a Return to Teenage Vaping
- August 22, 2019
Juul Users Inhaling Chemicals Not Listed
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