2023
Global, regional, and country-level cost of leptospirosis due to loss of productivity in humans
Agampodi S, Gunarathna S, Lee J, Excler J. Global, regional, and country-level cost of leptospirosis due to loss of productivity in humans. PLOS Neglected Tropical Diseases 2023, 17: e0011291. PMID: 37616329, PMCID: PMC10482283, DOI: 10.1371/journal.pntd.0011291.Peer-Reviewed Original ResearchConceptsGross domestic productDisability-adjusted life yearsProductivity costsWorld Bank data repositoryLoss of productivityHealth expenditure dataEconomic burden estimatesHigher productivity costsDomestic productExpenditure dataInternational dollarsOverall economic burdenMonetary valueEconomic burdenAsia-Pacific regionIntangible costsLife yearsEconomic costsCost estimatesIncome countriesDiseases of povertyPartial estimatesCostProductivityCountriesComplete genome sequences of twelve strains of Leptospira interrogans isolated from humans in Sri Lanka
Senavirathna I, Jayasundara D, Warnasekara J, Matthias M, Vinetz J, Agampodi S. Complete genome sequences of twelve strains of Leptospira interrogans isolated from humans in Sri Lanka. Infection Genetics And Evolution 2023, 113: 105462. PMID: 37301334, DOI: 10.1016/j.meegid.2023.105462.Peer-Reviewed Original Research‘We do not rush to the hospital for ordinary wounds (suḷu tuvāla)’: A qualitative study on the early clinical manifestations of cutaneous leishmaniasis and associated health behaviours in rural Sri Lanka
Gunasekara S, Wickramasinghe N, Agampodi S, Fernando M, Weerakoon K, Liyanage C, Dikomitis L, Agampodi T. ‘We do not rush to the hospital for ordinary wounds (suḷu tuvāla)’: A qualitative study on the early clinical manifestations of cutaneous leishmaniasis and associated health behaviours in rural Sri Lanka. PLOS Neglected Tropical Diseases 2023, 17: e0010939. PMID: 37172051, PMCID: PMC10208456, DOI: 10.1371/journal.pntd.0010939.Peer-Reviewed Original ResearchConceptsEarly clinical manifestationsClinical manifestationsCutaneous leishmaniasisHealth behaviorsRural Sri LankaAssociated health behaviorsHealthcare-seeking behaviorSelf-management actionsEarly skinTreatment periodFirst visitSkin lesionsQualitative studyHealth interventionsWorm infestationAnt bitesLeishmaniasisTropical diseasesNarrative thematic approachHealthcare facilitiesManifestationsRural settingsSymptomsAnuradhapura districtSubstantial delayThe stigma associated with cutaneous leishmaniasis (CL) and mucocutaneous leishmaniasis (MCL): A protocol for a systematic review
Nuwangi H, Agampodi T, Price H, Shepherd T, Weerakoon K, Agampodi S. The stigma associated with cutaneous leishmaniasis (CL) and mucocutaneous leishmaniasis (MCL): A protocol for a systematic review. PLOS ONE 2023, 18: e0285663. PMID: 37167276, PMCID: PMC10174477, DOI: 10.1371/journal.pone.0285663.Peer-Reviewed Original ResearchConceptsMucocutaneous leishmaniasisCutaneous leishmaniasisSystematic reviewVisceral leishmaniasisMeta-Analyses Protocols (PRISMA-P) statementCochrane Library databasesRisk of biasRegistered Systematic ReviewMain clinical typesGlobal Index MedicusPreferred Reporting ItemsWeb of ScienceClinical typesStrategies/interventionsDifferent study typesLibrary databasesElectronic searchReporting ItemsNarrative synthesisStudy typeIndex MedicusSkin pathologyLeishmaniasisTropical diseasesFull articles
2022
Culture-Independent Detection and Identification of Leptospira Serovars
Matthias M, Lubar A, Acharige S, Chaiboonma K, Pilau N, Marroquin A, Jayasundara D, Agampodi S, Vinetz J. Culture-Independent Detection and Identification of Leptospira Serovars. Microbiology Spectrum 2022, 10: e02475-22. PMID: 36445143, PMCID: PMC9769591, DOI: 10.1128/spectrum.02475-22.Peer-Reviewed Original ResearchConceptsPublic health importanceProspective studyFatal diseaseHealth importanceOutbreak investigationSequence typingDog urine samplesCulture-independent assaysEnvironmental surveillance studyMultilocus sequence typingPulsed-field gel electrophoresisSurveillance studyGroup IIHuman leptospirosisPrognostic testSpecific real-time qPCRClinical settingGroup ILeptospira serovarsReal-time qPCRDiagnostic testsSerum samplesUrine samplesDiagnostic specificityLeptospirosisInvolvement of alcohol in injury cases in rural Sri Lanka: prevalence and associated factors among in-patients in three primary care hospitals
Schölin L, Weerasinghe M, Agampodi S, Chathurange U, Rajapaksha S, Holloway A, Norrie J, Mohamed F, Eddleston M, Pearson M. Involvement of alcohol in injury cases in rural Sri Lanka: prevalence and associated factors among in-patients in three primary care hospitals. BMC Public Health 2022, 22: 514. PMID: 35296275, PMCID: PMC8928674, DOI: 10.1186/s12889-022-12958-8.Peer-Reviewed Original ResearchConceptsAlcohol-related injuriesAlcohol Use Disorders Identification TestBlood alcohol concentrationRural Sri LankaAlcohol useInjury characteristicsPrimary care hospitalHospital-based sampleTransport-related injuriesCurrent alcohol usersDisorders Identification TestCurrent alcohol useBinary logistic regressionInvolvement of alcoholHigher AUDIT scoresAdult patientsCare hospitalGlobal morbidityResultsA totalIntentional injuriesAcute intoxicationProblematic alcohol usePatientsPossible alcohol dependenceInjury cases
2021
Epidemiology of wheeze among preschool children: a population-based cross-sectional study from rural Sri Lanka
Mudiyanselage S, Amarasiri WADL, Yasaratne BMGD, Warnasekara J, Agampodi S. Epidemiology of wheeze among preschool children: a population-based cross-sectional study from rural Sri Lanka. BMJ Open 2021, 11: e046688. PMID: 34233982, PMCID: PMC8264903, DOI: 10.1136/bmjopen-2020-046688.Peer-Reviewed Original ResearchConceptsIndependent risk factorCross-sectional studySevere wheezeAllergic rhinitisPassive smokingRisk factorsFrequent consumptionPopulation-based cross-sectional studyRural Sri LankaPreschool childrenPrevalence of wheezeWheezing attacksFrequent symptomsSevere wheezingMean ageYear old childrenChildhood questionnaireSevere episodesWheezeFemale childrenProtective factorsOlder childrenStudy sampleSize samplingAsthmaticsNext-Generation Sequencing Analysis of Pathogenic Leptospira: A Way Forward for Understanding Infectious Disease Dynamics in Low/Middle-Income, Disease-Endemic Settings.
Agampodi SB, Vinetz JM. Next-Generation Sequencing Analysis of Pathogenic Leptospira: A Way Forward for Understanding Infectious Disease Dynamics in Low/Middle-Income, Disease-Endemic Settings. American Journal Of Tropical Medicine And Hygiene 2021, 104: 1625-1627. PMID: 33755589, PMCID: PMC8103479, DOI: 10.4269/ajtmh.20-1518.Peer-Reviewed Original Research12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka
Jayasundara D, Senavirathna I, Warnasekara J, Gamage C, Siribaddana S, Kularatne SAM, Matthias M, Mariet JF, Picardeau M, Agampodi S, Vinetz J. 12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka. PLOS Neglected Tropical Diseases 2021, 15: e0009272. PMID: 33735202, PMCID: PMC8009393, DOI: 10.1371/journal.pntd.0009272.Peer-Reviewed Original ResearchConceptsClonal groupsAcute kidney injuryL. interrogansMajor clinical challengeGlobal disease threatsLeptospira speciesL. interrogans infectionKidney injuryLiver impairmentCardiovascular involvementL. borgpeterseniiClinical presentationProspective studyClinical severityClinical challengePathogenic Leptospira speciesAnnual epidemicsUbiquitous zoonotic diseaseNew serogroupEpidemiological contextZoonotic diseaseCulture isolationLeptospiral culturesL. weiliiLeptospira diversity
2020
Is leishmaniasis adequately notified in Sri Lanka? A survey among doctors from an endemic district, Sri Lanka
Hewawasam C, Weerakoon HS, Thilakan V, Lelwala T, Prasanka K, Rathnayaka AS, Gamage S, Agampodi S. Is leishmaniasis adequately notified in Sri Lanka? A survey among doctors from an endemic district, Sri Lanka. BMC Public Health 2020, 20: 913. PMID: 32532244, PMCID: PMC7290071, DOI: 10.1186/s12889-020-09066-w.Peer-Reviewed Original ResearchConceptsMedical officersMethodsA cross-sectional studyFirst clinical suspicionHigh disease burdenCross-sectional studyHigh case loadSelf-administered questionnaireHealth Care InstituteAnuradhapura districtCurrent notification systemClinical suspicionResultsOne hundredDisease burdenCare instituteCausative organismEarly diagnosisEndemic districtsCutaneous leishmaniasisParasitic infectionsLeishmaniasisNotifiable diseaseCase loadLeishmania donovaniDiseaseSupportive staff
2019
A Case–Control Study of Environmental and Occupational Risks of Leptospirosis in Sri Lanka
Schønning MH, Phelps MD, Warnasekara J, Agampodi SB, Furu P. A Case–Control Study of Environmental and Occupational Risks of Leptospirosis in Sri Lanka. EcoHealth 2019, 16: 534-543. PMID: 31664587, DOI: 10.1007/s10393-019-01448-w.Peer-Reviewed Original ResearchConceptsPaddy workersOdds ratioSignificant higher riskCase-control studyHigher odds ratioPublic health interventionsTransmission of leptospirosisRisk factorsOccupational exposureProtective effectHigh riskHigh incidenceRat exposureHuman leptospirosisViral infectionHealth interventionsZoonotic infectionOccupational riskLeptospirosisLeptospirosis transmissionStudy sampleOccupational groupsInfectionStructured interviewsHousehold animalsIn vivo, ex vivo and in vitro evidence for atropine-mediated attenuation of glucagon-like peptide-1 secretion: findings from a systematic review
Rathish D, Agampodi S, Jayasumana C. In vivo, ex vivo and in vitro evidence for atropine-mediated attenuation of glucagon-like peptide-1 secretion: findings from a systematic review. Environmental Science And Pollution Research 2019, 26: 29597-29605. PMID: 31446595, DOI: 10.1007/s11356-019-06227-2.Peer-Reviewed Original ResearchConceptsGlucagon-like peptide-1GLP-1 secretionGlucagon-like peptide-1 secretionDipeptidyl peptidase-4 (DPP-4) enzymeRole of atropineVivo studiesPeptide-1 secretionRisk of biasPostprandial glucose homeostasisEx vivo studyPostprandial secretionCholinergic pathwaysAnticholinergic agentsCochrane LibraryHealthy menMuscarinic receptorsGlucose homeostasisPeptide-1Reference listsCompetitive antagonistHuman studiesAnimal studiesPRISMA statementSystematic reviewAtropine
2018
Uncommon Skin Response to the Stings of Tropical Fire Ant Solenopsis geminata
Wijerathne BTB, Rathnayake GK, Dias RKS, Wickramasinghe ND, Thalgaspitiya SPB, Karunaratne AH, Agampodi SB. Uncommon Skin Response to the Stings of Tropical Fire Ant Solenopsis geminata. Wilderness And Environmental Medicine 2018, 29: 551-554. PMID: 30145121, DOI: 10.1016/j.wem.2018.06.003.Peer-Reviewed Original Research
2016
From organophosphate poisoning to diabetes mellitus: The incretin effect
Rathish D, Agampodi SB, Jayasumana MACS, Siribaddana SH. From organophosphate poisoning to diabetes mellitus: The incretin effect. Medical Hypotheses 2016, 91: 53-55. PMID: 27142144, DOI: 10.1016/j.mehy.2016.04.002.Peer-Reviewed Original ResearchConceptsAccumulation of acetylcholineIncretin effectGlucose homeostasisDiabetes mellitusOP poisoningType 2 diabetes mellitusPeptide-1 secretionAcute OPMuscarinic receptorsTreatment modalitiesOrganophosphate poisoningPositive findingsInhibition of acetylcholinesterasesMellitusInduced disruptionHomeostasisPoisoningInhibitionDisruptionT2DMAcetylcholineGlucagonIncidenceSecretionReceptors
2014
Hornet Stings Presenting to a Primary Care Hospital in Anuradhapura District, Sri Lanka
Wijerathne BT, Rathnayake GK, Agampodi SB. Hornet Stings Presenting to a Primary Care Hospital in Anuradhapura District, Sri Lanka. Wilderness And Environmental Medicine 2014, 25: 122-126. PMID: 24411975, DOI: 10.1016/j.wem.2013.09.012.Peer-Reviewed Original Research
2013
Is There a Risk of Yellow Fever Virus Transmission in South Asian Countries with Hyperendemic Dengue?
Agampodi SB, Wickramage K. Is There a Risk of Yellow Fever Virus Transmission in South Asian Countries with Hyperendemic Dengue? BioMed Research International 2013, 2013: 905043. PMID: 24367789, PMCID: PMC3866876, DOI: 10.1155/2013/905043.Peer-Reviewed Original ResearchConceptsYellow feverYellow fever virus transmissionPublic health alertsAedes aegypti densityEndemic areasYF transmissionHealth authoritiesDengue burdenHealth alertsHealth officialsLocal transmissionVirus transmissionGlobal healthRiskMosquito densityLiterature pertainingActual riskSouth Asian countriesAsian countriesAegypti densityProbable riskSri LankaFeverPotential spread
2011
Spatial epidemiology of leptospirosis in Sri Lanka
AGAMPODI SB. Spatial epidemiology of leptospirosis in Sri Lanka. Epidemiology And Infection 2011, 140: 1530-1531. PMID: 22142588, DOI: 10.1017/s0950268811002512.Peer-Reviewed Original Research
2009
Evaluation of surveillance case definition in the diagnosis of leptospirosis, using the Microscopic Agglutination Test: a validation study
Dassanayake D, Wimalaratna H, Agampodi SB, Liyanapathirana VC, Piyarathna T, Goonapienuwala BL. Evaluation of surveillance case definition in the diagnosis of leptospirosis, using the Microscopic Agglutination Test: a validation study. BMC Infectious Diseases 2009, 9: 48. PMID: 19386085, PMCID: PMC2679753, DOI: 10.1186/1471-2334-9-48.Peer-Reviewed Original ResearchConceptsSurveillance case definitionMicroscopic agglutination testCase definitionNegative predictive valuePredictive valueClinical featuresMAT titresAgglutination testDays of feverAcute febrile illnessMethodsThe study populationTeaching Hospital KandyPositive predictive valueDiagnosis of leptospirosisPositive MAT resultsFebrile illnessMedical wardsResultsA totalHospital KandyStudy populationBlood samplesConclusionThis studyPatientsDiagnostic accuracyLeptospirosis