2021
Next-Generation Sequencing Analysis of Pathogenic Leptospira: A Way Forward for Understanding Infectious Disease Dynamics in Low/Middle-Income, Disease-Endemic Settings.
Agampodi SB, Vinetz JM. Next-Generation Sequencing Analysis of Pathogenic Leptospira: A Way Forward for Understanding Infectious Disease Dynamics in Low/Middle-Income, Disease-Endemic Settings. American Journal Of Tropical Medicine And Hygiene 2021, 104: 1625-1627. PMID: 33755589, PMCID: PMC8103479, DOI: 10.4269/ajtmh.20-1518.Peer-Reviewed Original Research
2014
Regional Differences of Leptospirosis in Sri Lanka: Observations from a Flood-Associated Outbreak in 2011
Agampodi SB, Dahanayaka NJ, Bandaranayaka AK, Perera M, Priyankara S, Weerawansa P, Matthias MA, Vinetz JM. Regional Differences of Leptospirosis in Sri Lanka: Observations from a Flood-Associated Outbreak in 2011. PLOS Neglected Tropical Diseases 2014, 8: e2626. PMID: 24454971, PMCID: PMC3894175, DOI: 10.1371/journal.pntd.0002626.Peer-Reviewed Original ResearchConceptsOutbreak of leptospirosisClinical presentationAcute renal failureDifferent clinical presentationsCross-sectional studyMedian bacterial loadPublic health interventionsPublic health relevanceLeptospira interrogans serovar laiRenal failureSevere thrombocytopeniaInfectious disease epidemicsDifferent Leptospira speciesEtiological causesImportant causeHealth interventionsHealth relevanceLeptospirosisTropical diseasesBacterial loadLeptospira kirschneriLeptospirosis outbreaksSerovar laiLeptospira speciesL. kirschneri
2012
Utility of Quantitative Polymerase Chain Reaction in Leptospirosis Diagnosis: Association of Level of Leptospiremia and Clinical Manifestations in Sri Lanka
Agampodi SB, Matthias MA, Moreno AC, Vinetz JM. Utility of Quantitative Polymerase Chain Reaction in Leptospirosis Diagnosis: Association of Level of Leptospiremia and Clinical Manifestations in Sri Lanka. Clinical Infectious Diseases 2012, 54: 1249-1255. PMID: 22354922, PMCID: PMC3404689, DOI: 10.1093/cid/cis035.Peer-Reviewed Original ResearchConceptsQuantitative polymerase chain reactionClinical manifestationsPolymerase chain reactionBlood samplesChain reactionWhole bloodOnset of symptomsSensitivity of qPCRAssociation of levelsSerum/bloodMicroscopic agglutination test panelValid diagnostic testPatient blood samplesOptimal sample typeFailure patientsRenal failureWhole blood samplesPatient populationTimely diagnosisLeptospiral loadEndemic areasDay 2Day 15LeptospiremiaDiagnostic tests