2023
Bacillus Calmette–Guérin Vaccine Attenuates Haloperidol-Induced TD-like Behavioral and Neurochemical Alteration in Experimental Rats
Yedke N, Upadhayay S, Singh R, Jamwal S, Ahmad S, Kumar P. Bacillus Calmette–Guérin Vaccine Attenuates Haloperidol-Induced TD-like Behavioral and Neurochemical Alteration in Experimental Rats. Biomolecules 2023, 13: 1667. PMID: 38002349, PMCID: PMC10669047, DOI: 10.3390/biom13111667.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntipsychotic AgentsBCG VaccineBehavior, AnimalHaloperidolRatsTardive DyskinesiaConceptsBCG vaccineTardive dyskinesiaOrofacial dyskinesiaNeurotransmitter levelsBacillus Calmette-Guérin (BCG) vaccineFirst-generation antipsychotic drugsManagement of TDOxidative stressLevels of HVACalmette-Guérin vaccineHyperkinetic movement disordersMajor pathophysiological mechanismsPro-apoptotic markersLong-term useBCG treatmentNeuroprotective effectsNeurochemical alterationsOrofacial dysfunctionPathophysiological mechanismsAntipsychotic medicationNeuromodulatory propertiesSuppress inflammationSingle administrationAntipsychotic drugsHaloperidol injection
2020
Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters
Thakur V, Jamwal S, Kumar M, Rahi V, Kumar P. Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters. Neurotoxicity Research 2020, 38: 359-369. PMID: 32506340, DOI: 10.1007/s12640-020-00231-y.Peer-Reviewed Original ResearchMeSH Keywords3,4-Dihydroxyphenylacetic AcidAnimalsAnxietyBehavior, AnimalBrainDisease Models, AnimalDopamineElectron Transport Complex IElectron Transport Complex IIElevated Plus Maze TestEnzyme InhibitorsFatigue Syndrome, ChronicGlutathioneHand StrengthHeme Oxygenase-1HeminHomovanillic AcidHydroxyindoleacetic AcidLipid PeroxidationLocomotionMetalloporphyrinsMiceMitochondriaNeurotransmitter AgentsNitritesNorepinephrineProtoporphyrinsSerotoninConceptsChronic fatigue syndromeMitochondrial complex dysfunctionFatigue syndromeProtective effectComplex dysfunctionMale albino miceAnxiety-like behaviorFatigue-like behaviorAntifatigue effectNeurotransmitter alterationsCommon symptomsPresent studyNeurotransmitter levelsSwimming testAlbino miceExperimental miceImmobility periodEnzyme inhibitorsProtective roleCognitive impairmentLocomotor activityBehavioral testsSwimming sessionBiochemical parametersBiochemical alterations
2015
Beneficial effects of lycopene against haloperidol induced orofacial dyskinesia in rats: Possible neurotransmitters and neuroinflammation modulation
Datta S, Jamwal S, Deshmukh R, Kumar P. Beneficial effects of lycopene against haloperidol induced orofacial dyskinesia in rats: Possible neurotransmitters and neuroinflammation modulation. European Journal Of Pharmacology 2015, 771: 229-235. PMID: 26712377, DOI: 10.1016/j.ejphar.2015.12.032.Peer-Reviewed Original ResearchConceptsOrofacial dyskinesiaHaloperidol treatmentChronic neuroleptic treatmentAbnormal involuntary movementsSevere side effectsNeuroinflammatory modulationNeuroleptic treatmentTardive dyskinesiaProtective effectInvoluntary movementsSide effectsDyskinesiaBiochemical parametersHaloperidolRatsTreatmentDaysLycopeneStriatum