L-theanine prevent quinolinic acid induced motor deficit and striatal neurotoxicity: Reduction in oxido-nitrosative stress and restoration of striatal neurotransmitters level
Jamwal S, Singh S, Gill JS, Kumar P. L-theanine prevent quinolinic acid induced motor deficit and striatal neurotoxicity: Reduction in oxido-nitrosative stress and restoration of striatal neurotransmitters level. European Journal Of Pharmacology 2017, 811: 171-179. PMID: 28624333, DOI: 10.1016/j.ejphar.2017.06.016.Peer-Reviewed Original ResearchConceptsStriatal neurotransmitter levelsOxido-nitrosative stressNeurotransmitter levelsProtective effectL-NAMEMotor deficitsQuinolinic acidL-arginineL-theanineNitric oxide synthase inhibitorPro-inflammatory cytokinesNitric oxide pathwayOxide synthase inhibitorOpen field testL-theanine treatmentRota-rodBeam walkingNeuro-inflammationNeurotransmitter alterationsNeuroprotective potentialStriatal neurotoxicityOxide pathwayQA injectionGrip strengthMotor coordinationNeuroprotective potential of quercetin in combination with piperine against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity
Singh S, Jamwal S, Kumar P. Neuroprotective potential of quercetin in combination with piperine against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. Neural Regeneration Research 2017, 12: 1137-1144. PMID: 28852397, PMCID: PMC5558494, DOI: 10.4103/1673-5374.211194.Peer-Reviewed Original ResearchSubstantia nigra pars compactaAnti-inflammatory propertiesPars compactaNeuroprotective potentialTetrahydropyridine-induced neurotoxicityInjection of MPTPStrong neuroprotective effectSignificant motor deficitsBioavailability of antioxidantsOpen field testOxidative stress parametersLow oral bioavailabilityNeuroinflammatory cytokinesMotor deficitsNeuroprotective effectsRotarod performanceCombination therapyDopaminergic neuronsGrip strengthInflammatory responseBilateral infusionsBehavioral abnormalitiesDay 1MPTPStereotaxic apparatus