L-theanine prevent quinolinic acid induced motor deficit and striatal neurotoxicity: Reduction in oxido-nitrosative stress and restoration of striatal neurotransmitters level
Jamwal S, Singh S, Gill JS, Kumar P. L-theanine prevent quinolinic acid induced motor deficit and striatal neurotoxicity: Reduction in oxido-nitrosative stress and restoration of striatal neurotransmitters level. European Journal Of Pharmacology 2017, 811: 171-179. PMID: 28624333, DOI: 10.1016/j.ejphar.2017.06.016.Peer-Reviewed Original ResearchConceptsStriatal neurotransmitter levelsOxido-nitrosative stressNeurotransmitter levelsProtective effectL-NAMEMotor deficitsQuinolinic acidL-arginineL-theanineNitric oxide synthase inhibitorPro-inflammatory cytokinesNitric oxide pathwayOxide synthase inhibitorOpen field testL-theanine treatmentRota-rodBeam walkingNeuro-inflammationNeurotransmitter alterationsNeuroprotective potentialStriatal neurotoxicityOxide pathwayQA injectionGrip strengthMotor coordinationNeuroprotective potential of quercetin in combination with piperine against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity
Singh S, Jamwal S, Kumar P. Neuroprotective potential of quercetin in combination with piperine against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. Neural Regeneration Research 2017, 12: 1137-1144. PMID: 28852397, PMCID: PMC5558494, DOI: 10.4103/1673-5374.211194.Peer-Reviewed Original ResearchSubstantia nigra pars compactaAnti-inflammatory propertiesPars compactaNeuroprotective potentialTetrahydropyridine-induced neurotoxicityInjection of MPTPStrong neuroprotective effectSignificant motor deficitsBioavailability of antioxidantsOpen field testOxidative stress parametersLow oral bioavailabilityNeuroinflammatory cytokinesMotor deficitsNeuroprotective effectsRotarod performanceCombination therapyDopaminergic neuronsGrip strengthInflammatory responseBilateral infusionsBehavioral abnormalitiesDay 1MPTPStereotaxic apparatusBehavioral Tests for Rodent Models
Jamwal S, Singh S, Bansal P. Behavioral Tests for Rodent Models. 2017, 315-341. DOI: 10.1007/978-981-10-5981-0_21.Peer-Reviewed Original ResearchMotor coordinationPerformance-based testsTraumatic brain injuryBrain injuryBehavioral testsTesting of drugsMotor activityRotating rodRotarod testGrip strengthMovement disordersRodent modelsAnimal modelsExperimental drugsPreclinical researchDrugsDisordersRodentsTestLatencyResearchRotarodInjuryCoordination