2021
Expression of PON2 isoforms varies among brain regions in male and female African green monkeys
Jamwal S, Blackburn JK, Elsworth JD. Expression of PON2 isoforms varies among brain regions in male and female African green monkeys. Free Radical Biology And Medicine 2021, 178: 215-218. PMID: 34890766, PMCID: PMC8760629, DOI: 10.1016/j.freeradbiomed.2021.12.005.Peer-Reviewed Original ResearchConceptsAfrican green monkeysParkinson's diseaseBrain regionsParaoxonase 2Different brain regionsFemale monkeysGreen monkeysPON2 expressionOxidative stress-related neurodegenerative disordersFemale African green monkeysNeurodegenerative disordersMale African green monkeysOxidative stressPON2 protein expressionAnti-inflammatory propertiesExpression levelsSignificant differencesBrain tissue samplesDorsolateral prefrontal cortexNeuroprotective strategiesWestern blotting techniquesDopaminergic neuronsPON2 proteinPrimate brainProtective role
2017
Animal Models of Parkinson’s Disease
Sharma N, Jamwal S, Singh S, Gill H, Bansal P. Animal Models of Parkinson’s Disease. 2017, 23-42. DOI: 10.1007/978-981-10-5981-0_3.Peer-Reviewed Original ResearchParkinson's diseaseDopaminergic neuronsLewy bodiesPrevalence of PDCranial nerve motor nucleiHypokinetic movement disordersNigrostriatal dopaminergic neuronsNon-motor symptomsMajor pathological featureAge related neurodegenerative diseasesRelated neurodegenerative diseasesInheritable genetic mutationsProgressive neurodegenerativeAutonomic dysfunctionOrthostatic hypotensionIdiopathic originNeuropsychiatric disturbancesCerebral cortexMotor manifestationsMotor nucleusNucleus basalisPathological featuresSleep disturbancesLocus coeruleusSelective degenerationNeuroprotective potential of quercetin in combination with piperine against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity
Singh S, Jamwal S, Kumar P. Neuroprotective potential of quercetin in combination with piperine against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. Neural Regeneration Research 2017, 12: 1137-1144. PMID: 28852397, PMCID: PMC5558494, DOI: 10.4103/1673-5374.211194.Peer-Reviewed Original ResearchSubstantia nigra pars compactaAnti-inflammatory propertiesPars compactaNeuroprotective potentialTetrahydropyridine-induced neurotoxicityInjection of MPTPStrong neuroprotective effectSignificant motor deficitsBioavailability of antioxidantsOpen field testOxidative stress parametersLow oral bioavailabilityNeuroinflammatory cytokinesMotor deficitsNeuroprotective effectsRotarod performanceCombination therapyDopaminergic neuronsGrip strengthInflammatory responseBilateral infusionsBehavioral abnormalitiesDay 1MPTPStereotaxic apparatus